Publications by authors named "Luca Spadea"
Article Synopsis
- Systemic lupus erythematosus (SLE) is a serious autoimmune disease that predominantly affects women and can cause damage to multiple organs, sometimes leading to life-threatening conditions.
- The disease is distinguished by the presence of autoantibodies that form immune complexes, leading to inflammation and organ damage, and its pathogenesis involves both innate and adaptive immune responses.
- Recent advancements have led to the development of targeted therapies that aim for personalized treatment, but these new drugs are currently meant to complement traditional, often toxic therapies while researchers continue to explore future treatment possibilities that could potentially cure SLE.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease involving the spine, peripheral joints, and entheses. This condition causes stiffness, pain, and significant limitation of movement. In recent years, several effective therapies have become available based on the use of biologics that selectively block cytokines involved in the pathogenesis of the disease, such as tumor necrosis factor-α (TNFα), interleukin (IL)-17, and IL-23.
View Article and Find Full Text PDFT-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) family, namely IL-17A and IL-17F. IL-17 in turn induces several target cells to synthesize and release cytokines, chemokines, and metalloproteinases, thereby amplifying the inflammatory cascade.
View Article and Find Full Text PDF: To investigate the etiology, clinical features, ocular complications, and visual outcomes in children with infectious uveitis referred to a tertiary uveitis hospital-based service. : Children with infectious uveitis were included in a retrospective cohort study. The data set was obtained after reviewing the medical records of pediatric patients with uveitis of different causes referred to our center during the period from 2009 to 2019.
View Article and Find Full Text PDF: Interleukin-17 (IL-17) is a cytokine family consisting of six members and five specific receptors. IL-17A was the first member to be identified in 1993. Since then, several studies have elucidated that IL-17 has predominantly pro-inflammatory activity and that its production is involved in both the defense against pathogens and the genesis of autoimmune processes.
View Article and Find Full Text PDF