Publications by authors named "Luca Pompei"
Article Synopsis
- Endovascular treatment (EVT) is advised for acute ischemic stroke caused by large-vessel occlusion (LVO) in patients with a decent early CT score (ASPECTS ≥ 6), but recent studies examine its effectiveness in patients with more severe strokes (ASPECTS 0-5).
- A meta-analysis of six randomized controlled trials (involving 1656 patients) found that EVT significantly improves functional independence and the chances of achieving good functional outcomes after 90 days compared to best medical treatment (BMT) alone.
- Although EVT leads to higher rates of symptomatic intracranial hemorrhage (sICH), the benefits in terms of improved function at three months outweigh the risks, especially for patients with large
The control of IL-12 production from dendritic cells (DCs) and macrophages in response to Mycobacterium tuberculosis (Mtb) is not well understood. The objective of this study was to pursue the mechanism underlying our previous report that in response to Mtb infection, DCs release abundant IL-12, whereas secretion is limited in macrophages. An initial comparison of IL-12p35 and IL-12p40 gene induction showed that p35 transcription is similar in murine bone marrow-derived DCs and macrophages, but a rapid and enhanced IL-12p40 transcription occurs only in DCs.
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