Partial Reduction in Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.

is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the gene causing inferior survival of breast cancer patients. Most studies have focused on the analysis of complete loss or mutations in functional domains of .