Publications by authors named "Luca Nesterenko"
Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk.
Am J Physiol Heart Circ Physiol
June 2020
Article Synopsis
- SAP97 is a key scaffolding protein that supports the function of cardiac ion channels, influencing heart excitability, and potential arrhythmias.
- Researchers created a mouse model to study the effects of removing SAP97 on heart function, which revealed serious ECG abnormalities and increased risk of arrhythmias.
- No mutations were identified in long QT syndrome cases, but a novel human mutation linked to Brugada syndrome was discovered, indicating SAP97's role in heart disease risk through its interactions with ion channels.