Publications by authors named "Luca Mela"
Aim: To evaluate the indication of the endodontic treatment for vital intact teeth with the root apex involved in large radicular cystic lesions of endodontic origin.
Methodology: This prospective cohort study enrolled healthy participants with radicular cysts of endodontic origin and with the root apex of vital intact teeth involved in the bone defect, as determined by cone beam computed tomography (CBCT). Thirty-two sound vital teeth were analysed by thermal (TPT) and electric pulp tests (EPT) before surgery (T0) and 1 week (T1), 2 weeks (T2), 3 months (T3) and 6 months (T4) post-surgery.
Article Synopsis
- Mesenchymal stem cells (MSCs) can be sourced from the oral cavity, specifically from dental pulp and buccal fat pads, making them valuable for regenerative medicine.
- The study compared the osteoinductive potential of dental pulp stem cells (DPSCs) and buccal fat pad stem cells (BFPSCs) harvested from 12 patients, finding a higher cell yield and proliferation rate in BFPSCs.
- Both types of stem cells successfully differentiated into osteoblast-like cells and released a mineralized matrix, with BFPSCs showing a greater but not statistically significant release of osteocalcin, indicating potential for regenerative applications.