Effectiveness and Tolerability of Repeated Courses of Viscosupplementation in Symptomatic Hip Osteoarthritis: A Retrospective Observational Cohort Study of High Molecular Weight Medium Molecular Weight Hyaluronic Acid No Viscosupplementation.

Nonsurgical management of symptomatic hip osteoarthritis needs real-world evidence. We evaluated the effectiveness and tolerability of US-guided intra-articular treatment of two hyaluronic acids (HAs) commercially available in Italy and investigated predictors of response. Outpatient records including three cohorts: 122 subjects treated with medium (1,500-3,200 kDa; Hyalubrix) molecular weight (MW) or high (hylan G-F20; Synvisc) MW HAs and 20 controls taking NSAIDs/analgesics on demand were retrospectively analyzed.