Publications by authors named "Luca Lee"
The prevalence of post-traumatic stress disorder (PTSD) is higher in females than males, but pre-clinical models are established almost exclusively in males. This study is aimed to investigate the stress-enhanced fear learning model of PTSD in females. The model mirrors PTSD symptomology in males, whereby prior stress leads to extinction resistant exaggerated contextual fear memory.
View Article and Find Full Text PDFStress enhances aggression in male rats with genetic stress hyper-reactivity.
Genes Brain Behav
October 2024
Article Synopsis
- - The study examined how stress influences aggression in two genetically distinct male mouse strains: the stress-hyper-reactive Wistar Kyoto More Immobile (WMI) and the control Wistar Kyoto Less Immobile (WLI), using a resident-intruder test.
- - Prior acute stress led to decreased social interactions and aggression in adult WLIs, but increased aggression in stressed adult WMIs toward both same-age and juvenile intruders, indicating a genetic predisposition to stress-induced aggression.
- - Genetic analysis revealed alterations in aggression-related genes between strains, with specific changes in the frontal cortex and amygdala of WMIs after stress, suggesting that their genetic makeup contributes to heightened aggression under stress, potentially opening pathways for future research on