Publications by authors named "Luca K"

Background: Research on perception of chiropractic is abundant in Western contexts, yet sparse in Asia. This study aims to bridge this gap by examining the perceptions of chiropractic among Taiwanese adults, focusing on demographics, utilisation, beliefs, and understanding.

Methods: An adapted survey with 27 close-ended items was administered to assess Taiwanese adults' perception of chiropractic.

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Purpose: This study characterizes lung SBRT dose conformity for a noncoplanar VMAT technique.

Methods: Retrospectively, 288 previously treated lung SBRT cases were replanned using a VMAT technique of two ipsilateral 180° arcs separated by 30° couch angles. Two objectives were used for optimization: a lower objective to achieve PTV coverage and a custom NTO to steepen the dose gradient.

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Purpose: Deep learning-based segmentation of organs-at-risk (OAR) is emerging to become mainstream in clinical practice because of the superior performance over atlas and model-based autocontouring methods. While several commercial deep learning-based autosegmentation solutions are now available, the implementation of these tools is still at such a primitive stage that acceptance criteria are underdeveloped due to a lack of knowledge about the systems' segmentation tendencies and failure modes. As the starting point of the iterative process of clinical implementation, this study focuses on the outlier analysis of four commercial autocontouring tools for the abdominal OARs.

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Background: Recent patient studies have linked higher immune cell doses with worse quality of life and survival. For thoracic radiotherapy, heart dose is a major contributor to the effective dose to immune cells (EDIC).

Purpose: This study investigates heart and immune cell doses for plans optimized using a cardiac-sparing knowledge-based planning (KBP) model and the impact of carefully crafted beam geometry.

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Background: Diagnostic imaging is commonly used in the management of low back pain (LBP), with approximately one-quarter of those who present to primary care referred for imaging. Current estimates of imaging frequency commonly exclude older adults; however, pathology detected with imaging (e.g.

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To investigate the dosimetric impact of laterality-specific RapidPlan models for nonsmall cell lung cancer. Three RapidPlan models were developed and validated for Right, Left, and General conventional lung radiotherapy. Each model was trained using 50 plans.

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Article Synopsis
  • DNA damage repair is essential for genomic integrity and cellular health, but detecting it in individual cells has been challenging.
  • The study uses innovative techniques (DamID and ChIC sequencing) to analyze how repair proteins localize in response to DNA double-strand breaks, revealing variability in damage locations and repair features.
  • Findings indicate that repair proteins cluster in large chromatin hubs, enhancing their coordination and suggesting a preference for cooperative repair mechanisms across the genome.
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This study investigated optimization settings that steepen the dose gradient as a function of target size for lung stereotactic body radiation therapy (SBRT). Sixty-eight lung SBRT patients with planning target volumes (PTVs) ranging from 2-203 cc were categorized into small (<20 cc), medium (20-50 cc), and large (>50 cc) groups. VMAT plans were generated using the normal tissue objective (NTO) to penalize the dose gradient at progressively steeper NTO fall-off values (0.

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This study investigated a straightforward treatment planning technique for definitive stereotactic body radiation therapy (SBRT) for patients with early-stage lung cancer aimed at increasing dose to gross disease by strategically penalizing the normal tissue objective (NTO) in the Eclipse treatment planning system. Twenty-five SBRT cases were replanned to 50 Gy in 5 fractions using static and dynamic NTO methods (50 plans total). The NTO had a start dose of 100% at the target border, end dose of 20%, fall-off rate of 0.

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In the human and veterinary fields, oral vaccines generate considerable interest. In dogs, these vaccines are newly developed, and understanding their mechanisms is crucial. Mesenteric lymph nodes (MLNs) and Peyer's patches (PPs) are important sites for gastrointestinal mucosal induction, yet canine MLNs lack sufficient information.

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Background: Despite the well-known benefits of physical activity, physical inactivity is presently a global health pandemic. Allied healthcare providers, such as chiropractors, knowingly recognise the importance of physical activity and are prepared to routinely discuss and/or counsel patients on this topic; however, little is known about Australian chiropractors in the physical activity setting. Our aim was to explore and identify factors associated with physical activity promotion among Australian chiropractors, including their knowledge of the physical activity and sedentary behaviour guidelines and their own levels of physical activity.

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Purpose: To investigate bolus design and VMAT optimization settings for total scalp irradiation.

Methods: Three silicone bolus designs (flat, hat, and custom) from .decimal were evaluated for adherence to five anthropomorphic head phantoms.

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Objectives: Developing a research agenda is one method to facilitate broad research planning and prioritise research within a discipline. Despite profession-specific agendas, none have specifically addressed the research needs of the specialty of sports chiropractic. This study determined consensus on research priorities to inform a global sports chiropractic research agenda.

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Gene expression programs result from the collective activity of numerous regulatory factors. Studying their cooperative mode of action is imperative to understand gene regulation, but simultaneously measuring these factors within one sample has been challenging. Here we introduce Multiplexing Antibodies by barcode Identification (MAbID), a method for combinatorial genomic profiling of histone modifications and chromatin-binding proteins.

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Article Synopsis
  • Oral vaccination is effective for stimulating immune responses, with GALT and Peyer's patches being key players; however, our knowledge about these systems in dogs is still limited.
  • The research involved advanced techniques like immunofluorescence, flow cytometry, and single-cell RNA sequencing to study canine Peyer's patches and their immune cell populations.
  • The development of a specific antibody targeting canine M cells will assist in understanding how antigens enter the dog's GALT, providing insights for future studies on dog immune responses and diseases.
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Objective: Our objective was to evaluate the effectiveness of a three-month physiotherapist-delivered eHealth physical activity program compared with usual care to improve function in adults with low back pain or knee osteoarthritis in rural Australia.

Methods: This was a parallel, two-group, pragmatic, superiority, randomized controlled trial involving three- and six-month posttreatment follow-ups. There was a total of 156 adults with chronic nonspecific low back pain (n = 97) or knee osteoarthritis (n = 59) from rural Australia.

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Article Synopsis
  • Research on low back pain (LBP) has been increasing, with a focus on two groups: older adults (LBP-O) and working-age adults (LBP-W), but comparative trends between these populations have not been thoroughly examined.
  • A total of 4217 LBP-O articles and 50,559 LBP-W articles published from 1993 to 2023 were analyzed, revealing an increase in publication rates for both groups, with the U.S. leading in contributions, primarily through the journal "Spine."
  • Key topics in LBP-O included cognitive behavioral therapy and physical activity, while LBP-W emphasized surgery and intervertebral disc degeneration, reflecting a need for a more biopsychosocial approach
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Background: Pregnancy-related low back and/or pelvic girdle pain is common, with a prevalence rate of up to 86% in pregnant women. Although 19.5% of Australian pregnant women visit a chiropractor for pelvic girdle pain, little is known about the experience of pregnant women who seek this care.

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Introduction: The increasing prevalence of coexisting health conditions poses a challenge to healthcare providers and healthcare systems. Spinal pain (eg, neck and back pain) and spinal pathologies (eg, osteoporotic fractures and degenerative spinal disease) exist concurrently with other non-spinal health conditions (NSHC). However, the scope of what associations may exist among these co-occurring conditions is unclear.

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This study evaluated the feasibility of using artificial intelligence (AI) segmentation software for volume-modulated arc therapy (VMAT) prostate planning in conjunction with knowledge-based planning to facilitate a fully automated workflow. Two commercially available AI software programs, Radformation AutoContour (Radformation, New York, NY) and Siemens AI-Rad Companion (Siemens Healthineers, Malvern, PA) were used to auto-segment the rectum, bladder, femoral heads, and bowel bag on 30 retrospective clinical cases (10 intact prostate, 10 prostate bed, and 10 prostate and lymph node). Physician-segmented target volumes were transferred to AI structure sets.

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The goal of this study is to investigate the Pareto optimal tradeoffs between target coverage and hippocampal sparing using knowledge-based multicriteria optimization (MCO). Ten prior clinical cases were selected that were treated with hippocampal avoidance whole brain radiotherapy (HA-WBRT) using VMAT. A new, balanced plan was generated for each case using an in-house RapidPlan model in the Eclipse V16.

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Article Synopsis
  • This work presents a new method for quickly creating high-quality CT images from low-quality CBCT images, aiding in adaptive radiotherapy.
  • The authors modify a technique called contrastive unpaired translation (CUT) for medical imaging and test it on a pelvic CT dataset.
  • The results show that CUT performs better than an existing method called cycleGAN, using fewer resources and time, thereby enhancing the effectiveness of online adaptive radiotherapy.
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Article Synopsis
  • - The genus consists of multiple species, with one primarily causing whooping cough in humans, leading to varied severity of infections in children and adults, and its prevalence is on the rise globally.
  • - This pathogen also affects a wide range of mammals, notably causing chronic cough in dogs through the canine infectious respiratory disease complex, while concurrently increasing its role in human infections.
  • - There are distinct vaccines for humans and animals that differ in their formulation and immune responses, and understanding the interaction between veterinary and human health is critical for controlling infections and preventing zoonotic transmission.
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