Publications by authors named "Luca GroSS"
Article Synopsis
- Guanylate-binding proteins (GBPs) are important enzymes in the immune system that help defend against infections by forming protective coats around pathogens.
- Researchers used cryo-electron microscopy to visualize the structure of GBP1 when bound to guanine nucleotides, revealing how it interacts with bacterial membranes.
- The study highlights that changes in GBP1's structure during nucleotide binding enable it to effectively attach to and disrupt the membranes of certain bacteria, shedding light on its role in the body's immune response.
Parkinson's disease is the second most common neurodegenerative disease. It is characterized by aggregation of the protein α-synuclein (α-syn) in Lewy bodies, mitochondrial dysfunction, and increased oxidative stress in the substantia nigra. Oxidative stress leads to several modifications of biomolecules including dityrosine (DiY) crosslinking in proteins, which has recently been detected in α-syn in Lewy bodies from Parkinson's disease patients.
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