Publications by authors named "Luca Ginnari-Satriani"
Article Synopsis
- The study examines how the compound azatrux binds to a specific human telomeric G-quadruplex using various scientific methods, including spectroscopy and calorimetry, especially under crowded molecular conditions.
- Azatrux binds to the G-quadruplex in an end-stacking fashion, and the research identifies important structural features that aid this binding.
- The compound shows a strong preference for binding to the human telomeric G-quadruplex compared to another G-quadruplex and duplex DNA when crowding is present, indicating its selectivity.
A series of bay-substituted perylene derivatives is reported as a new class of G-quadruplex ligands. The synthesized compounds have differing N-cyclic substituents on the bay area and differing side chains on the perylene major axis. ESI-MS and FRET measurements highlighted the strongest quadruplex binders in this series and those showing the highest quadruplex/duplex selectivity.
View Article and Find Full Text PDFA new hydrosoluble triazatruxene derivative (Azatrux) is reported to selectively bind to G-quadruplex DNA, as derived by ESI-MS measurements and competition experiments.
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