Publications by authors named "Luca Dirheimer"
Peptide-mediated targeting of Quantum Dots in a 3D model of head and neck cancer.
Photodiagnosis Photodyn Ther
October 2024
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is primarily treated with surgery, and positive surgical margins negatively impact patient survival; fluorescence guided surgery (FGS) using quantum dots (QDs) linked to a specific peptide (A20FMDV2) may enhance tumor removal and margin assessment.
- In experiments with 2D and 3D tongue cancer models, different types of QDs were tested for their ability to accumulate in cancer cells, with QDs meant to target the αVβ6 integrin showing promise.
- Results indicated that QDs with sulfobetaine polymers obstructed cell entry, while peptide-conjugated QDs effectively labeled cancer cells, penetrating the spheroid periphery, but showed no significant
Purpose: The tumor microenvironment (TME) is composed of various stromal components, including immune cells such as tumor-associated macrophages (TAMs), which play a crucial role in cancer initiation and progression. TAMs can exhibit either a tumor-suppressive M1 or a tumor-promoting M2 phenotype. First, we aimed to develop a 3D human heterotypic model consisting of head and neck squamous cell carcinoma (HNSCC) cells and different subtypes of macrophages to replicate the interactions between immune cells and cancer cells.
View Article and Find Full Text PDFQuantum Dots (QDs) are fluorescent nanoparticles known for their exceptional optical properties, i.e., high fluorescence emission, photostability, narrow emission spectrum, and broad excitation wavelength.
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