Publications by authors named "Luca Cristiano"
Article Synopsis
- Low-grade endotoxemia, caused by lipopolysaccharide (LPS), is detected in COVID-19 patients, potentially promoting thrombosis through a pro-inflammatory and pro-coagulant state.
- The study measured various biomarkers in 175 COVID-19 patients and 50 healthy controls, finding significantly elevated levels of markers like sNOX2-dp and D-dimer in COVID-19 patients, especially those with acute respiratory distress syndrome (ARDS).
- Results suggest that factors like impaired gut barrier function, high NOX2 activation, and low albumin may lead to low-grade endotoxemia, increasing the risk of thrombotic events in COVID-19 patients.
Pathophysiology of portal vein thrombosis (PVT) in cirrhosis is still not entirely understood. Elevated levels of lipopolysaccharides (LPS) in portal circulation are significantly associated with hypercoagulation, increased platelet activation and endothelial dysfunction. The aim of the study was to investigate if LPS was associated with reduced portal venous flow, the third component of Virchow's triad, and the underlying mechanism.
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