Publications by authors named "Luca Cicchetti"
SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis.
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- COVID-19 patients with pneumonia display significant alterations in their monocytes, which are often overlooked despite their critical role in inflammation.
- Analysis showed these monocytes exhibit mitochondrial dysfunction, decreased respiration capabilities, and reduced aerobic glycolysis, indicating impaired energy production.
- There is also a notable shift in monocyte types, with an increase in pro-inflammatory and immature monocytes, along with elevated levels of inflammatory markers in the blood, underscoring their contribution to the disease's immune response.
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1CD57 exhausted T cells.
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