Publications by authors named "Luc Lotteau"
Article Synopsis
- The study investigates how A549 alveolar epithelial cells respond to perfluorocarbon (PFC) exposure during total liquid ventilation compared to the standard medium DMEM.
- Using confocal fluorescent microscopy and multiscale magnetic twisting cytometry (MTC), researchers analyze changes in cell structure, mechanics, and adhesion related to F-actin and glycocalyx.
- Results indicate that PFC exposure leads to F-actin remodeling, reduced cytoskeleton stiffness, and weakened cell adhesion, suggesting that cells adapt to lower adhesion energy when exposed to PFC, potentially affected by surfactants.
Introduction: Total liquid ventilation (TLV) can cool down the entire body within 10-15 min in small animals. Our goal was to determine whether it could also induce ultra-fast and whole-body cooling in large animals using a specifically dedicated liquid ventilator. Cooling efficiency was evaluated under physiological conditions (beating-heart) and during cardiac arrest with automated chest compressions (CC, intra-arrest).
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