Some pharmacokinetics of sevoflurane in a child with severe lipodystrophy.

Lipodystrophies are acquired or inherited disorders characterized in part by the selective loss of adipose tissue and hypertriglyceridemia. The present case report of 2 sevoflurane anesthetics given to a child with such a disorder, before and after correction of severe hypertriglyceridemia, illustrates the considerable effects of increased serum lipids and decreased fat stores on the pharmacokinetics of sevoflurane.

Postoperative results after desflurane or sevoflurane combined with remifentanil in morbidly obese patients.

Background: This randomized prospective study with blinded postanesthesia care unit (PACU) observers compared the recovery profiles in morbidly obese patients who received sevoflurane or desflurane for maintenance of anesthesia in combination with a remifentanil target controlled infusion (TCI).

Methods: 50 morbidly obese patients scheduled for laparoscopic gastric banding were included to receive BIS-guided sevoflurane or desflurane anesthesia with BIS-triggered inhalation boli in combination with remifentanil TCI. In the PACU, the following recovery scores were investigated: Modified Aldrete score, a modified Observers' Assessment of Alertness/Sedation Scale (OAA/S), pain numerical rating scale (NRS), oxygen saturation (SpO(2)) and postoperative nausea and vomiting (PONV).

Ambulatory electrical external cardioversion with propofol or etomidate.

Study Objective: To compare, in pairwise fashion, the effects of propofol and etomidate during ambulatory cardioversion and early recovery.

Design: Clinical, prospective, randomized, blinded, monocenter, pairwise, comparative study

Setting: OR and recovery area of the electrophysiological department, University Hospital Ghent, Belgium.

Patients: 34 patients with atrial arrhythmia who were scheduled for repetitive electrical cardioversion, of whom 25 patients completed the study.