Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma.

Objective: To describe and correlate neurotoxicity indicators in long-term primary CNS lymphoma (PCNSL) survivors who were treated with high-dose methotrexate-based regimens with or without whole-brain radiotherapy (WBRT).

Methods: Eighty PCNSL survivors from 4 treatment groups (1 with WBRT and 3 without WBRT) who were a minimum of 2 years after diagnosis and in complete remission underwent prospective neuropsychological, quality-of-life (QOL), and brain MRI evaluation. Clinical characteristics were compared among treatments by using the χ(2) test and analysis of variance.

A chick model of retinal detachment: cone rich and novel.

Background: Development of retinal detachment models in small animals can be difficult and expensive. Here we create and characterize a novel, cone-rich retinal detachment (RD) model in the chick.

Methodology/principal Findings: Retinal detachments were created in chicks between postnatal days 7 and 21 by subretinal injections of either saline (SA) or hyaluronic acid (HA).

Susac syndrome: an organ-specific autoimmune endotheliopathy syndrome associated with anti-endothelial cell antibodies.

Susac syndrome (SS) is the triad of encephalopathy, branch retinal artery occlusions (BRAOs), and hearing loss. Migraines may herald and accompany encephalopathy. Little is known about pathogenesis.

Retinal and optic nerve head pathology in Susac's syndrome.

Purpose: This article describes the first retinal histopathologic findings in a patient with Susac's syndrome (SS).

Design: Observational case report.

Participant: A 51-year-old white woman diagnosed with SS.

Endoscopic orbital roof fenestration as an alternative treatment option for idiopathic intracranial hypertension: a cadaveric anatomical study.

Background: We investigated a new minimally invasive surgical technique for the treatment of idiopathic intracranial hypertension in a cadaveric model. This technique aims at establishing a communication between the intraorbital and intracranial compartments by creating a bone, dural, and periorbital window in the anterior cranial fossa. This procedure is predicated on intraorbital absorptive capability that has been demonstrated in animals and discussed in humans.

Endoscopic transconjunctival surgical approach to the optic nerve and medial intraconal space: a cadaver study.

Objective: Surgical approaches to the orbit require great precision and care because of the functional and aesthetic importance of this region. Conventional approaches to the posterior orbit often require bone removal, may disrupt extraocular muscles, and may create external surgical scars. We conceived a transconjunctival surgical approach to the medial intraconal space that is aided by a minimally invasive endoscopic technique and avoids muscle transection.

Cerebrospinal fluid outflow: an evolving perspective.

Cerebrospinal fluid (CSF) serves numerous important functions in the central nervous system. Despite numerous reports characterizing CSF and its circulation in the subarachnoid space, our understanding of CSF outflow remains limited. Although initial work suggested that both arachnoid granulations and lymphatic capillaries shared in the role of CSF outflow, predominant work since then has focused on the arachnoid granulations.

Ex vivo model of cerebrospinal fluid outflow across human arachnoid granulations.

Purpose: The brain's arachnoid membrane with granulations is an important biological barrier whose responsibilities include the transmission of cerebrospinal fluid (CSF) and the regulation of pressure. Membrane disturbance may cause changes that are difficult to replicate with animal models, suggesting the need for a model using human arachnoid membrane with granulations for the study of conditions such as Alzheimer disease, hydrocephalus, and pseudotumor cerebri. The authors detail the development and validation of an ex vivo model of CSF outflow across human arachnoid granulations (AGs) as an approximation of in vivo conditions.

Aggressive immunosuppressive treatment of Susac's syndrome in an adolescent: using treatment of dermatomyositis as a model.

We describe aggressive immunosuppressive treatment of an adolescent with Susac's syndrome (SS), a disease of the microvasculature in the brain, retina, and inner ear. Because the immunopathogenesis of SS appears to have much in common with that of juvenile dermatomyositis (JDM), the patient was treated with an approach that has been effective for severe JDM. The patient's outcome provides evidence for the importance of prompt, aggressive, and sustained immunosuppressive treatment of encephalopathic SS.

Vision loss after spine surgery: review of the literature and recommendations.

In recent studies spinal surgery has replaced cardiac surgery as a leading cause of postoperative vision loss (POVL). Estimates of the incidence of POVL after spinal surgery range from 0.028 to 0.

Susac's syndrome: 1975-2005 microangiopathy/autoimmune endotheliopathy.

Susac's syndrome (SS) consists of the clinical triad of encephalopathy, branch retinal artery occlusions (BRAO) and hearing loss. It is due to a microangiopathy affecting the precapillary arterioles of the brain, retina, and inner ear (cochlea and semicircular canals). Women are more commonly affected than men (3:1); the age of onset ranges from 9 to 58 years; but young women between the ages of 20 and 40 are most vulnerable.

In vitro model of cerebrospinal fluid outflow through human arachnoid granulations.

Purpose: To describe and validate an in vitro model of the arachnoid granulation (AG) outflow pathway for cerebrospinal fluid (CSF), by using human AG cells grown on a filter membrane support and perfused in a modified Ussing chamber at pressures analogous to normal human intracranial pressures.

Methods: Human AG cells were grown, characterized, seeded onto filter membranes, and perfused in the physiologic (basal to apical, B-->A) or nonphysiologic (apical to basal, A-->B) directions. Cells were fixed under pressure after perfusion and prepared for electron microscopy (EM).

Characterization of cytoskeletal and junctional proteins expressed by cells cultured from human arachnoid granulation tissue.

Background: The arachnoid granulations (AGs) are projections of the arachnoid membrane into the dural venous sinuses. They function, along with the extracranial lymphatics, to circulate the cerebrospinal fluid (CSF) to the systemic venous circulation. Disruption of normal CSF dynamics may result in increased intracranial pressures causing many problems including headaches and visual loss, as in idiopathic intracranial hypertension and hydrocephalus.

Visual loss with West Nile virus infection: a wider spectrum of a "new" disease.

We describe a case of severe visual loss as a result of West Nile virus (WNV) infection. Associated headache and fever led to the proper diagnosis and management, but the findings of optic neuritis, retinitis, and uveitis were a surprising and prominent component of the patient's meningitis syndrome. Physicians diagnosing and treating patients with WNV infection should be alerted to the possibility of ocular and optic nerve involvement, which may leave permanent neuropathic residua.

West Nile virus-associated optic neuritis and chorioretinitis.

Purpose: To report the new ocular and neurologic features of West Nile virus (WNV) meningoencephalitis.

Design: Observational case report.

Methods: A 55-year-old woman presented with headache, stiff neck, visual loss, and fever 10 days after a weekend camping trip.

Expression of somatostatin receptors 1 and 2 in human choroid plexus and arachnoid granulations: implications for idiopathic intracranial hypertension.

Objective: To investigate the localization of somatostatin receptor types 1 and 2 in human choroid plexus (CP) and arachnoid granulations (AGs) by immunohistochemistry.

Methods: A prospective study was performed in an institutional setting. Immunohistochemistry was performed on 15 samples of CP and 12 samples of AGs from 15 patients who died with no signs or symptoms of intracranial disease (age range, 52-81 years).

Orbital "shanking": a unique prison injury.

The purpose of this paper is to describe orbitocranial penetration due to "shanking", a common mode of assault in prison facilities. We report the case of a prisoner who presented with orbital apex syndrome 5 days after an assault. He died 9 days after surgical removal of the "shank" due to a presumed ruptured traumatic aneurysm.