Publications by authors named "Lubov Borisovna Mitrofanova"
Article Synopsis
- Myxofibrosarcoma is a rare heart tumor primarily treated through surgical resection, but it may not always be operable.
- A 40-year-old female patient with recurrent myxofibrosarcoma of the left atrium underwent surgery and was initially diagnosed with an inflammatory myofibroblastic tumor, but after recurrences, the final diagnosis was confirmed as myxofibrosarcoma.
- Due to the tumor’s invasive growth and recurrence, a heart transplant was deemed necessary, highlighting that transplants can improve life expectancy in cases of inoperable cardiac sarcomas.
Article Synopsis
- This study analyzes the clinical and morphological characteristics of COVID-19 patients who died during four different waves of the pandemic, focusing on myocardium samples from autopsies.
- A total of 276 patients were examined, with various histological and molecular techniques used, revealing that only 5% had myocarditis, and a significant percentage of those expressed viral proteins.
- The findings highlighted differences in cardiovascular complications across the waves, with variations in incidence rates of hemorrhage, myocardial necrosis, blood clots, and myocarditis, indicating changing disease patterns over time.
Article Synopsis
- Congenital hyperinsulinism (CHI) exists in three forms: diffuse (CHI-D), focal (CHI-F), and atypical (CHI-A), with surgical treatment relying on preoperative imaging and intraoperative diagnosis.
- The study involved 35 CHI patients and analyzed PET/CT data, cytological, and immunohistochemical features of pancreatic samples, revealing significant differences in cell types and protein expressions among the CHI forms compared to a control group.
- The findings suggest that quantitative cytological and immunohistochemical analysis can aid in the intraoperative diagnosis of CHI forms, highlighting the potential for developing targeted therapy using a NeuroD1 inhibitor.
Unlabelled: NeuroD1's roles in the pathogenesis of pituitary adenomas and in the biology of the normal adult pituitary gland have been insufficiently researched. Much of the work investigating its expression patterns has yielded contradictory results.
Objective: morphological study of NeuroD1 transcription factor expression in different types of pituitary adenomas and in normal adult human pituitary glands.