Allergic sensitization pattern as a marker of bronchial hyperresponsiveness in allergic rhinitis patients living in temperate continental climate zone.

Background: Bronchial hyperresponsiveness (BHR) is a key feature of asthma, but it may also appear in allergic rhinitis. The type of allergen, as well as regional characteristics, play an important role in the development of BHR. The aim of our study was to analyze allergen sensitization patterns and the factors that affect BHR in allergic rhinitis patients living in temperate continental climate zone.

Occupational diseases in the automotive industry from medical and geographic viewpoints - comparison between the Czech Republic and the Slovak Republic.

Objective: The aim of the study was to compare the occurrence of occupational diseases (ODs) in the automotive industry in the Czech Republic and the Slovak Republic and to analyze their determinants.

Methods: The aggregated and anonymized data on ODs from the period 2001-2017 were used. A questionnaire survey was conducted in the Czech Republic (response rate 70.

Antimicrobial Activity of Protein Fraction from Venom Against .

One of the key problems of modern infectious disease medicine is the growing number of drug-resistant and multi-drug-resistant bacterial strains. For this reason, many studies are devoted to the search for highly active antimicrobial substances that could be used in therapy against bacterial infections. As it turns out, snake venoms are a rich source of proteins that exert a strong antibacterial effect, and therefore they have become an interesting research material.

Changes in occupational asthma during four decades in Slovakia, Central Europe.

Introduction: Occupational asthma (OA) is the most common occupational lung disease in industrialized countries; however, in Western Europe, a decline in the prevalence of OA and changes in etiological factors has been recorded. Data from Central Europe, where in the past healthcare and economy sectors were different, are rare.

Objective: The aim of this study was to discover the changes related to OA during a four decade long period in the Slovak Republic.

Different clinical effect of several types of airborne allergens on the severity of bronchial hyperreactivity.

Background: Atopic sensitization belongs to the most common risk factors for bronchial asthma. However, in clinical practice, it is not clear whether sensitization against pollen and perennial allergens is differently associated with the severity of bronchial hyperresponsiveness (BHR).

Aim: To find out whether patients sensitized to perennial allergens differ in severity of bronchial hyperresponsiveness from patients sensitized to pollen allergens.

Occupational rhinitis in the Slovak Republic--a long-term retrospective study.

Background: Allergic and non-allergic rhinitis ranks among the common occupational health problems. However, data on the incidence of occupational rhinitis are lacking, since comprehensive studies are rare.

Methods: The study includes a group of patients in the Slovak Republic who were reported as having occupational rhinitis in the years 1990-2011.

Effects of partially ionised medical oxygen, especially with O2•-, in vibration white finger patients.

A major symptom of hand-arm vibration syndrome is a secondary Raynaud's phenomenon-vibration white finger (VWF)-which results from a vasospasm of the digital arteries caused by work with vibration devices leading to occupational disease. Pharmacotherapy of VWF is often ineffective or has adverse effects. The aim of this work was to verify the influence of inhalation of partially ionized oxygen (O2•-) on peripheral blood vessels in the hands of patients with VWF.

Occupational viral hepatitis in the Slovak and the Czech Republic.

Background: The proportion of occupational infectious diseases (ID) in the total number of occupational diseases reported in the Slovak Republic (SR) and the Czech Republic (CR) was decreasing from 1973 to 2010. Our study presents a longitudinal analysis of the occurrence of occupational infectious diseases in the Slovak Republic and the Czech Republic in the period from 1973-2010 with special focus on viral hepatitis.

Methods: The sources of data were national health statistics of Czechoslovakia, the Czech Republic and the Slovak Republic.

Latent airway hyperresponsiveness: a phenomenon bordering bronchial asthma definition.

The basic features of bronchial asthma are dyspnea with wheezing and objectively confirmed obstructive respiratory disorder reversible after inhalation of bronchodilators. In stable intermittent bronchial asthma, these features are not present; therefore confirmation of asthma consists of the presence of bronchial hyperresponsiveness (BHR). In the present study, there were 902 bronchoprovocation tests performed for the verification of BHR.

Antioxidant and detoxifying enzymes in the liver of rats after subchronic inhalation of the mixture of cyclic hydrocarbons.

The activity of antioxidant and detoxifying enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), the SOD isoenzyme patterns and the contents of thiobarbituric acid reactive substances (TBARS), were determined in the livers of male and female rats after subchronic inhalation of mixtures of benzene, cyclohexanone and cyclohexane. Except for decreased GSHPx (with substrate cumene hydroperoxide) and GST activities in female rats, no differences in the activities of antioxidant and detoxifying enzymes and TBARS content occurred. Between the activities of GSHPx and GST was observed an indirect relationship.