Publications by authors named "Luaye Samarah"
Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease.
Am J Physiol Heart Circ Physiol
October 2024
Numerous genes including sarcospan (SSPN) have been designated as obesity-susceptibility genes by human genome-wide association studies. Variants in the locus have been linked with sex-dependent obesity-associated traits; however, this association has not been investigated in vivo. To delineate the role SSPN plays in regulating metabolism with potential to impact cardiac function, we subjected young and aged global SSPN-deficient (SSPN) male and female mice to obesogenic conditions (60% fat diet).
View Article and Find Full Text PDFHigh-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice.
Am J Physiol Heart Circ Physiol
April 2023
Article Synopsis
- Excess salt intake is linked to hypertension and arterial issues in humans, but similar effects are not seen in inbred mouse strains on a high-salt diet.
- * In a study using outbred UM-HET3 mice, a high-salt diet (4% NaCl) resulted in increased systolic blood pressure and aortic stiffness over 12 weeks compared to a low-salt diet (1% NaCl).
- * The research indicates that high-salt diets can lead to cardiovascular changes in genetically diverse mice, offering insights into how salt affects human arterial health.*
Western diet (WD), characterized by excess saturated fat and sugar intake, is a major contributor to obesity and metabolic and arterial dysfunction in humans. However, these phenotypes are not consistently observed in traditional inbred, genetically identical mice. Therefore, we sought to determine the effects of WD on visceral adiposity and metabolic/arterial function in UM-HET3 mice, an outbred, genetically diverse strain of mice.
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