Transrectal saturation technique may improve cancer detection as an initial prostate biopsy strategy in men with prostate-specific antigen <10 ng/ml.

Background: Using transrectal saturation prostate biopsy (SPBx) as an initial strategy remains a controversial topic.

Objective: To compare SPBx with extended prostate biopsy (EPBx) as an initial biopsy template in a large sequential cohort study.

Design, Setting, And Participants: We reviewed 438 men with initial SPBx and 3338 men who underwent initial EPBx between January 2002 and October 2011.

Female circumcision: history, medical and psychological complications, and initiatives to eradicate this practice.

Female circumcision - a procedure where the parts of the female genitals are removed, which is also known as female genital cutting (FGC) or female genital mutilation (FGM) - continues to be practiced in more than 28 African countries. It is estimated that 80-100 million women have been circumcised. We performed a review of the literature to examine the history of female circumcision, its medical and psychological consequences, and government and non-government educational initiatives that are currently being taken to eradicate this practice.