Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.

Introduction: Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.

Methods: 58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly.

Ischemic Postconditioning of the Liver Graft in Adult Liver Transplantation.

Background: Ischemia-reperfusion (I/R) injury is the main cause of graft failure in liver transplantation (LT). Ischemic postconditioning (IPo) has shown to be beneficial against I/R injury. Our objective was to compare the results of LT with or without IPo.

Impact of reversible cardiac arrest in the brain-dead organ donor on the outcome of adult liver transplantation.

Several donor and graft characteristics are associated with higher failure rates for deceased donor liver transplantation (LT). The influence of reversible cardiac arrest in the donor on these failure rates is unclear because of scarce and inconsistent data. The aim of this study was to determine whether reversible cardiac arrest in the donor could affect the early postoperative outcome of LT.

Oncologic results of laparoscopic versus open hepatectomy for colorectal liver metastases in two specialized centers.

Objective: Compare oncologic results of laparoscopic versus open hepatectomy for resection of colorectal metastases to the liver.

Summary And Background Data: Open hepatectomy (OH) is the current standard of care for the management of colorectal liver metastases. Although the feasibility of laparoscopic hepatectomy (LH) has been established, only select centers have used this technique as their primary modality.

Surgical approaches to solitary parathyroid adenoma: state of the art. Our early experience with intraoperative parathyroid hormone measurement.

We report our early experience with focused radioguided parathyroidectomy with intraoperative parathyroid hormone measurement in patients affected by primary hyperparathyroidism. Over a period of 2 months we performed 4 consecutive focused parathyroidectomies with intraoperative parathyroid hormone measurement, 3 of which radioguided. All patients had a preoperative localization of single gland disease by sestamibi scanning and/or ultrasound.

[Stromal tumors of the rectum: a case report and review of the literature].

This paper describes a case of epithelioid leiomyosarcoma of the rectum in a patient admitted for constipation and rectal bleeding. After an initial biopsy diagnosis of leiomyoma, a local excision was performed, showing the malignant nature of the tumour. Consequently, the patient underwent an abdomino-perineal amputation, adjuvant radiation (50 Gy) and a 24-month follow-up, which revealed no signs of local or distant recurrence.