Publications by authors named "Luana Nosetti"

Background/objectives: Obstructive Sleep Apnoea Syndrome (OSA) in children disrupts normal breathing patterns and sleep architecture, potentially leading to severe consequences. Early identification and intervention are crucial to prevent these issues. This study explored the relationships between waiting times for polysomnography (PSG), clinical history, patient age at the time of PSG, and PSG outcomes in children.

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(1) Background: Sleep-disordered breathing and asthma are often interrelated. Children and adults with asthma are more susceptible to sleep apnea. Inhaled corticosteroids effectively reduce inflammation and prevent structural changes in the airways.

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(1) Background: Sudden Infant Death Syndrome (SIDS) represents sudden and unexplained deaths during the sleep of infants under one year of age, despite thorough investigation. Screening for a prolonged QTc interval, a marker for Long QT Syndrome (LQTS), should be conducted on all newborns to reduce the incidence of SIDS. Neonatal electrocardiograms (ECGs) could identify congenital heart defects (CHDs) early, especially those not detected at birth.

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Article Synopsis
  • The study investigated the frequency and features of gastroesophageal reflux (GER) in infants who cry persistently without an obvious cause, focusing on those aged 0-12 months.
  • Out of 50 infants studied, 60% had normal conditions according to MII-pH monitoring, despite 66% of them showing abnormal scores on a reflux questionnaire.
  • The findings suggest that nocturnal crying in infants should not routinely lead to the use of acid suppressants, as abnormal MII-pH results were not reliably predicted by symptoms or regurgitation episodes.
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(1) Background: Sleep-disordered breathing represents a growing public health concern, especially among children and adolescents. The main risk factors for pediatric sleep-disordered breathing in school-age children are tonsillar and adenoid hypertrophy. Adenoidectomy, often in combination with tonsillectomy, is the primary treatment modality for pediatric sleep-disordered breathing.

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  • Brief Resolved Unexplained Events (BRUEs) are short episodes in children showing changes in breathing, consciousness, and skin color, and they've been linked to SARS-CoV-2 infection in healthy kids.
  • A study compared BRUE cases before and during the COVID-19 pandemic, revealing an increase in cases during the pandemic, with higher birth infection risks but less ongoing symptomatic infections and fever during the episodes.
  • The results may impact how healthcare providers manage children with BRUEs in the context of the ongoing pandemic.
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  • This review examines how pediatric obstructive sleep apnea (OSA), often linked to enlarged tonsils and adenoids, affects children's cardiovascular health, particularly the risk of pulmonary hypertension.
  • After analyzing 230 articles, the study included data from 20 articles involving over 2400 children, using various tools to ensure the reliability of the findings.
  • The research found that OSA and adenotonsillar hypertrophy significantly increase the risk of cardiovascular issues, and surgeries like adenoidectomy and tonsillectomy may help reduce pulmonary artery pressure, but the effectiveness varies among individuals and highlights the need for more targeted clinical studies.
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  • Obstructive Sleep Apnea Syndrome (OSAS) affects 1-5% of children and is associated with various health issues, potentially linked to inflammatory processes and heightened adrenaline production.* -
  • This pilot study examined the levels of β2-adrenergic receptor (ADRB2) expression and inflammatory markers IL-6 and IL-8 in the white blood cells of pediatric OSAS patients both before and after adenotonsillectomy.* -
  • Results showed that the surgery significantly lowered ADRB2, IL-6, and IL-8 expression levels, suggesting new insights into OSAS treatment and its inflammatory mechanisms.*
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  • * A detailed literature review evaluated studies focusing on the connection between SDB and ASD, resulting in the inclusion of seven key articles that indicate a high prevalence of SDB in this population, complicated by factors like obesity.
  • * Multidisciplinary strategies, including physiotherapy and specific weight management, along with possible surgical options such as adenotonsillectomy, are necessary for improving health outcomes for children with ASD experiencing SDB.
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Article Synopsis
  • Adenotonsillar hypertrophy is a major cause of sleep-disordered breathing in children, which can range from normal growth to problematic enlargement, leading to various health issues.
  • Adenotonsillectomy is the main treatment but isn't consistently effective for all patients, highlighting a need for better predictors and understanding of treatment outcomes.
  • The relationship between craniofacial development and adenotonsillar hypertrophy suggests a cycle that needs more research, including the impact on craniofacial growth and the exploration of new therapies for resistant cases.
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Background: Obstructive sleep apnea can have a negative impact on children's and adolescents' neurocognitive abilities and hinder their academic and adaptive progress in academic, social, and/or behavioral dimensions. In this retrospective cross-sectional study, we investigated the influence of body weight conditions and allergy status on long-term mental health, cognitive development, and quality of life in children and adolescents who snored.

Methods: The study sample included 47 subjects (age range 4.

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Pediatric obstructive sleep apnea can negatively affect children's neurocognitive function and development, hindering academic and adaptive goals. Questionnaires are suitable for assessing neuropsychological symptoms in children with sleep-disordered breathing. The study aimed to evaluate the effectiveness of using the Oxygen Desaturation Index compared to the Obstructive Apnea-Hypopnea Index in predicting long-term consequences of sleep-disordered breathing in children.

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(1) Background: Sleep-disordered breathing (SDB) is a frequent problem in children. Cluster analyses offer the possibility of identifying homogeneous groups within a large clinical database. The application of cluster analysis to anthropometric and polysomnographic measures in snoring children would enable the detection of distinctive clinically-relevant phenotypes; (2) Methods: We retrospectively collected the results of nocturnal home-based cardiorespiratory polygraphic recordings and anthropometric measurements in 326 habitually-snoring otherwise healthy children.

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Since the beginning of 2020, a remarkably low incidence of respiratory virus hospitalizations has been reported worldwide. We prospectively evaluated 587 children, aged <12 years, admitted for respiratory tract infections from 1 September 2021 to 15 March 2022 in four Italian pediatric hospitals to assess the burden of respiratory viruses during the COVID-19 pandemic in Italy. At admission, a Clinical Respiratory Score was assigned and nasopharyngeal or nasal washing samples were collected and tested for respiratory viruses.

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Study Objectives: Obstructive sleep apnea (OSA) in children is associated with acute metabolic, cardiovascular, and neurocognitive abnormalities. The long-term outcomes of childhood OSA into adulthood have not been established. We performed a 20-year follow-up of patients with polysomnography-documented OSA in childhood compared to a healthy control group to evaluate the long-term anthropometric, sleep, cognitive, and cardiovascular outcomes.

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Introduction: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder in children and is characterized by recurrent total or partial upper airway collapse episodes during sleep. OSA is associated with cardiovascular, metabolic and neurobehavioural complications related to sympathetic nervous system (SNS) activation. A key role in originating these complications and in underlying pathophysiologic mechanisms can be attributed to altered catecholamines (CAs) metabolism.

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Objective: Coagulation and inflammatory parameters are mildly altered in children with SARS-CoV-2 (COVID-19) infection, and laboratory evidence of a proinflammatory and procoagulant state has been noted in multisystem inflammatory syndrome in children (MIS-C). It is not clear whether this pediatric condition is related to thrombotic events. With this study we reviewed the literature for thrombotic complications in children with COVID-19 infection and MIS-C.

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A brief unexplained resolved event (BRUE) is an event observed in a child under 1 year of age in which the observer witnesses a sudden, brief but resolved episode of change in skin color, lack of breathing, weakness or poor responsiveness. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease-2019 (COVID-19). We report the case of a previously healthy, full-term infant infected with SARS-CoV-2 when he was 8 months old.

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Objective: Several evidences demonstrate that pre-sleep habits may negatively impact adolescent sleep, yet few data exist on Italian population. This study aimed to investigate the relationship between pre-sleep habits, use of technology/activity and sleep in Italian adolescents.

Methods: Self-report questionnaires including Italian version of School Sleep Habits Survey and use of technology/activity (eg smartphone, PC) at bedtime were administered to 972 adolescents (13-19 years) from Lombardia.

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: Prader-Willi syndrome (PWS) is the most well-known condition of genetic obesity. Over the past 20 years, advances have been achieved in the diagnosis and treatment of PWS with a significant improvement in prognosis.: This review focuses on the benefits of multidisciplinary approach in children and adolescents with PWS.

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Cow's milk allergy (CMA) and gastro-esophageal reflux disease (GERD) may manifest with similar symptoms in infants making the diagnosis challenging. While immediate reaction to cow's milk protein indicate CMA, regurgitation, vomiting, crying, fussiness, poor appetite, sleep disturbances have been reported in both CMA and GERD and in other conditions such as functional gastrointestinal disorders, eosinophilic esophagitis, anatomic abnormalities, metabolic and neurological diseases. Gastrointestinal manifestations of CMA are often non-IgE mediated and clinical response to cow's milk free diet is not a proof of immune system involvement.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19), a severe illness leading to pneumonia, multiorgan failure, and death. With this study, we performed a systematic review of the literature and ongoing clinical trials on convalescent plasma therapy in pediatric patients with COVID-19. The electronic databases Medline PubMed, Scopus, and Web Of Science were searched.

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Unlabelled: • IUI is a risk factor for spontaneous preterm birth and contributes to prematurity-associated mortality and morbidity.• HCA greatly affected Apgar's score and lung management of VLBWI at birth and later on with increased incidence of BPD.• HCA + FUN did not significantly impact on respiratory outcome.

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