Evidence for the druggability of aldosterone targets in heart failure: A bioinformatics and data science-driven decision-making approach.

Background: Aldosterone plays a key role in the neurohormonal drive of heart failure. Systematic prioritization of drug targets using bioinformatics and database-driven decision-making can provide a competitive advantage in therapeutic R&D. This study investigated the evidence on the druggability of these aldosterone targets in heart failure.