Cannabinoid CB receptor agonist reduces local and systemic inflammation associated with pneumonia-induced sepsis in mice.

Sepsis is a severe condition secondary to dysregulated host response to infection leading to tissue damage and organ dysfunction. Cannabinoid CB receptor has modulatory effects on the immune response. Therefore, this study investigated the effects of a cannabinoid CB receptor agonist on the local and systemic inflammatory process associated with pneumonia-induced sepsis.