Chloride intracellular channel CLIC3 mediates fibroblast cellular senescence by interacting with ERK7.

Cellular senescence (CS) is recognized as a critical driver of aging and age-related disorders. Recent studies have emphasized the roles of ion channels as key mediators of CS. Nonetheless, the roles and regulatory mechanisms of chloride intracellular channels (CLICs) during CS remain largely unexplored.

A randomized prospective study to compare the efficacy of 308-nm light-emitting diode and 308-nm excimer lamp in the treatment of facial vitiligo.

Background: Previous studies have proven that 308-nm light-emitting diode(308-nm LED)and 308-nm excimer lamp(308-nm MEL) are effective in treating vitiligo, but there is a lack of comparison of their efficacy for facial lesions.

Objective: To evaluate and contrast the treatment success rates of 308-nm LED versus 308-nm excimer lamp in managing facial lesions among patients suffering from stable non-segmental vitiligo.

Methods: The enrolled 119 patients with 145 lesions were randomly assigned to receive 308-nm LED or 308-nm MEL for two months.

Leadless pacemaker implantation after delayed atrial lead perforation and battery depletion: a case report.

Background: Delayed lead perforation is a rare complication of cardiac implantable electronic device (CIED). Clinical presentations range from completely asymptomatic to pericardial tamponade. Surgical lead extraction is recommended and transvenous lead extraction (TLE) with surgical backup is an alternative method.

Solubility-Limited Small Molecule for Stable High-Capacity Potassium Storage.

Small molecule electrode materials with superb redox activity have significant applied implications for K-ion storage, but they face significant challenges like high solubility in electrolytes and low conductivity, limiting their capacity, rate, and cycling stability. Herein, a series of Ni-bis(dithiolene) (NiS)-based small molecules are designed with control of various redox-active substitutional groups for K-ion batteries anode materials. It is identified that bis[1,2-di(pyridine-4-yl) ethylene-1,2-dithiolate] nickel Ni[CSPy] demonstrates a high reversible specific capacity (399 mAh g at 0.

Establishment of MS LOC platform and its pilot application in clinical lipidomics.

Lipidomics has demonstrated significant potential for disease diagnosis and prediction. The development and optimization of a robust mass spectrometry (MS) platform for lipidome analysis is critically important, as it can facilitate biomarker discovery, cohort testing, and performance evaluation in clinical lipidomics studies. In this work, we developed a high-throughput and reliable platform, termed MS Lab on a Chip (MS LOC), which integrates the MetArray chip, an automated lipidomics pretreatment protocol, and the reflectron matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) instrument.

The dissolution and bioavailability of curcumin reinforced by loading into porous starch under solvent evaporation.

Curcumin is a polyphenol with anti-inflammatory and antitumorigenic properties. However, its low water solubility and bioavailability limit its use. In this study, porous starch supplemented with a solvent evaporation process was demonstrated as a highly loaded vehicle for curcumin (17.

Efficacy and safety of hetrombopag in the treatment of recombinant human thrombopoietin-resistant thrombocytopenia after allogeneic hematopoietic stem cell transplantation.

Background: Thrombocytopenia after allogeneic hematopoietic cell transplantation is a challenging clinical problem. Recombinant human thrombopoietin (rhTPO) and thrombopoietin receptor agonists are increasingly used in posttransplant thrombocytopenia. However, the use of hetrombopag in patients with posttransplant thrombocytopenia, especially in patients with resistance to rhTPO, has not yet been reported.

Research on the Laser Scattering Characteristics of Three-Dimensional Imaging Based on Electro-Optical Crystal Modulation.

In this paper, we construct a laser 3D imaging simulation model based on the 3D imaging principle of electro-optical crystal modulation. Unlike the traditional 3D imaging simulation method, this paper focuses on the laser scattering characteristics of the target scene. To accurately analyze and simulate the scattering characteristic model of the target under laser irradiation, we propose a BRDF (Bidirectional Reflectance Distribution Function) model fitting algorithm based on the hybrid BBO-Firefly model, which can accurately simulate the laser scattering distribution of the target at different angles.

Snapshotting quantum dynamics at multiple time points.

Measurement-induced state disturbance is a major challenge in obtaining quantum statistics at multiple time points. We propose a method to extract dynamic information from a quantum system at intermediate time points, namely snapshotting quantum dynamics. To this end, we apply classical post-processing after performing the ancilla-assisted measurements to cancel out the impact of the measurements at each time point.

Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling.

Increased levels of lactoferrin (Lf) are present in the aged brain and in the lesions of various neurodegenerative diseases, including Parkinson's disease (PD), and may contribute to the cascade of events involved in neurodevelopment and neuroprotection. However, whether Lf originates from astrocytes and functions within either the normal or pathological brain are unknown. Here, we employed mice with specific knockout of the astrocyte lactoferrin gene (named Lf-cKO) to explore its specific roles in the pathological process of PD.

nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.

The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that pancreatic epithelial nSMase2 ablation reduces neoplasia and promotes a PDA subtype switch from aggressive basal-like to classical.

Targeted apoptosis of senescent cells by valproic acid alleviates therapy-induced cellular senescence and lung aging.

Background: Accumulation of senescent cells in tissues and their downstream effect programs have emerged as key drivers of aging and age-associated pathologies. Recent progresses in senotherapeutics indicated that either selectively killing senescent cells with senolytics or suppressing the senescence-associated secretory phenotype (SASP) secretion using senomorphics contributes to extending of the healthy lifespan and alleviating numerous age-related disorders in mice.

Purpose: However, the potential side-effects and long-term cytotoxicity of the above novel compounds have not yet been determined.

Troxerutin Delays Skin Keratinocyte Senescence Induced by Ionizing Radiation Both In Vitro and In Vivo.

Backgrounds: With the increasing demand for beauty and a healthy lifespan, studies regarding anti-skin aging have drawn much more attention than ever before. Skin cellular senescence, the primary cause of skin aging, is characterized by a cell cycle arrest in proliferating cells along with a senescence-associated secretory phenotype (SASP), which can be triggered by various internal or external stimuli.

Aims: Recent studies have made significant progress in the fields of anti-senescence and anti-aging.

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia.

Purpose: This study investigates alterations in intrinsically photosensitive retinal ganglion cells (ipRGCs) and dopaminergic amacrine cells (DACs) in lid suture myopia (LSM) rats.

Methods: LSM was induced in rats by suturing the right eyes for 4 weeks. Double immunofluorescence staining of ipRGCs and DACs in whole-mount retinas was performed to analyze changes in the density and morphology of control, LSM, and fellow eyes.

Research on Polarization Modulation of Electro-Optical Crystals for 3D Imaging Reconstruction.

A method for enhancing the resolution of 3D imaging reconstruction by employing the polarization modulation of electro-optical crystals is proposed. This technique utilizes two polarizers oriented perpendicular to each other along with an electro-optical modulation crystal to achieve high repetition frequency and narrow pulse width gating. By varying the modulation time series of the electro-optical crystal, three-dimensional gray images of the laser at different distances are acquired, and the three-dimensional information of the target is reconstructed using the range energy recovery algorithm.

Research on Student's T-Distribution Point Cloud Registration Algorithm Based on Local Features.

LiDAR offers a wide range of uses in autonomous driving, remote sensing, urban planning, and other areas. The laser 3D point cloud acquired by LiDAR typically encounters issues during registration, including laser speckle noise, Gaussian noise, data loss, and data disorder. This work suggests a novel Student's t-distribution point cloud registration algorithm based on the local features of point clouds to address these issues.

Facet-Dependent Evolution of Active Components on Spinel CoO for Electrochemical Ammonia Synthesis.

Spinel cobalt oxides (CoO) have emerged as a promising class of catalysts for the electrochemical nitrate reduction reaction (eNORR) to ammonia, offering advantages such as low cost, high activity, and selectivity. However, the specific role of crystallographic facets in determining the catalysts' performance remains elusive, impeding the development of efficient catalysts. In this study, we have synthesized various CoO nanostructures with exposed facets of {100}, {111}, {110}, and {112}, aiming to investigate the dependence of the eNORR activity on the crystallographic facets.