Publications by authors named "Luan C Tonelli"
Article Synopsis
- In rodents, haloperidol treatment causes psychomotor impairments resembling Parkinsonism, with acute treatment leading to catalepsy and sub-chronic treatment reducing exploratory behavior.
- Researchers explored whether playback of 50-kHz ultrasonic vocalizations (USV), an appetitive sound, could help alleviate these motor deficits induced by haloperidol in rats.
- The study found that sub-chronic haloperidol led to reduced activity, but the playback of 50-kHz USV significantly improved exploratory behaviors and social responses in treated rats, indicating a potential for symptom relief.
Paradoxical kinesia is a sudden transient ability of akinetic patients to perform motor tasks they are otherwise unable to perform. This phenomenon is known to depend on the patient's emotional state and external stimuli. Paradoxical kinesia can be induced by appetitive 50-kHz ultrasonic vocalizations (USV) in rats displaying catalepsy following systemic haloperidol.
View Article and Find Full Text PDFParadoxical kinesia refers to a sudden transient ability of akinetic patients to perform motor tasks they are otherwise unable to perform. The mechanisms underlying this phenomenon are unknown due a paucity of valid animal models that faithfully reproduce paradoxical kinesia. Here, in a first experiment, we present a new method to study paradoxical kinesia by "awakening" cataleptic rats through presenting appetitive 50-kHz ultrasonic vocalizations (USV), which are typical for social situations with positive valence, like juvenile play or sexual encounters ("rat laughter").
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