Douglas Pouch Fluid Improves the Accuracy of Transvaginal Ultrasound in the Diagnosis of Uterosacral Ligaments Deep Infiltration Endometriosis: A Prospective Study.

Objectives: To compare the accuracy of transvaginal ultrasound (TVUS) with laparoscopy in detecting and characterizing uterosacral ligament (USL) nodules of deep infiltrative endometriosis (DIE) between patients with and without pouch of Douglas (POD) fluid.

Methods: This prospective study was conducted between June 2021 and July 2023. We included patients from the Second People's Hospital of Shenzhen with two TVUS tests: no POD fluid on the first TVUS test and POD fluid on the second TVUS test.

Efficacy and safety of transarterial chemoembolization plus lenvatinib combined with PD-1 inhibitors versus transarterial chemoembolization plus lenvatinib for unresectable hepatocellular carcinoma: a meta-analysis.

Background: Locoregional treatment combined with systemic therapy is expected to play a synergistic anticancer role. We conducted this systemic meta-analysis to examine the efficacy and safety of transarterial chemoembolization (TACE) plus lenvatinib with or without programmed cell death protein-1 (PD-1) inhibitors (TLP group) compared with TACE + lenvatinib (TL group) for unresectable hepatocellular carcinoma (uHCC).

Methods: From the inception date to April 2024, the data from PubMed, EMBASE, the Cochrane Library, Ovid, Web of Science, and Clinical Trials.

Multi-receptor skin with highly sensitive tele-perception somatosensory.

The limitations and complexity of traditional noncontact sensors in terms of sensitivity and threshold settings pose great challenges to extend the traditional five human senses. Here, we propose tele-perception to enhance human perception and cognition beyond these conventional noncontact sensors. Our bionic multi-receptor skin employs structured doping of inorganic nanoparticles to enhance the local electric field, coupled with advanced deep learning algorithms, achieving a Δ/Δ sensitivity of 14.

Efficacy and safety of PD-1 inhibitors plus anti-angiogenesis tyrosine kinase inhibitors with or without transarterial chemo(embolization) for unresectable hepatocellular carcinoma: a meta-analysis.

Background: The triple combination of programmed cell death protein-1 (PD-1) inhibitors plus anti-angiogenesis tyrosine kinase inhibitors (TKIs) with or without transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) enhance the effect of treatment for unresectable hepatocellular carcinoma (uHCC). The present study compared the efficacy and safety of PD-1 plus TKI with or without transarterial chemo(embolization) for uHCC.

Methods: The meta-analysis was conducted using data acquired from PubMed, EMBASE, the Cochrane Library, Ovid, Web of Science, and Clinical Trials.

Clinical Effectiveness and Safety of Transarterial Chemoembolization: Hepatic Artery Infusion Chemotherapy Plus Tyrosine Kinase Inhibitors With or Without Programmed Cell Death Protein-1 Inhibitors for Unresectable Hepatocellular Carcinoma-A Retrospective Study.

Background: Locoregional treatment with transarterial chemoembolization (TACE) or hepatic artery infusion chemotherapy (HAIC) and systemic targeted immunotherapy with tyrosine kinase inhibitors (TKI) and programmed cell death protein-1 (PD-1) inhibitors in the treatment of unresectable hepatocellular carcinoma (uHCC) have achieved promising efficacy. The retrospective study aimed to evaluate the efficacy and safety of TACE and HAIC plus TKI with or without PD-1 for uHCC.

Patients And Methods: From November 2020 to February 2024, the data of 44 patients who received TACE-HAIC + TKI + PD-1 (THKP group) and 34 patients who received TACE-HAIC + TKI (THK group) were retrospectively analyzed.

Effects of nutritional interventions on cognitive function in adult cancer survivors: A systematic review.

Aim: To evaluate the effectiveness and safety of nutritional interventions (i.e. nutritional support, dietary patterns and dietary supplements) on cognitive function in cancer survivors.

Giant Iontronic Flexoelectricity in Soft Hydrogels Induced by Tunable Biomimetic Ion Polarization.

Flexoelectricity features the strain gradient-induced mechanoelectric conversion using materials not limited by their crystalline symmetry, but state-of-the-art flexoelectric materials exhibit very small flexoelectric coefficients and are too brittle to withstand large deformations. Here, inspired by the ion polarization in living organisms, this paper reports the giant iontronic flexoelectricity of soft hydrogels where the ion polarization is attributed to the different transfer rates of cations and anions under bending deformations. The flexoelectricity is found to be easily regulated by the types of anion-cation pairs and polymer networks in the hydrogel.

Variation of the Start Date of the Vegetation Growing Season (SOS) and Its Climatic Drivers in the Tibetan Plateau.

Climate change inevitably affects vegetation growth in the Tibetan Plateau (TP). Understanding the dynamics of vegetation phenology and the responses of vegetation phenology to climate change are crucial for evaluating the impacts of climate change on terrestrial ecosystems. Despite many relevant studies conducted in the past, there still remain research gaps concerning the dominant factors that induce changes in the start date of the vegetation growing season (SOS).

Changes in soil aggregate stability and aggregate-associated carbon under different slope positions in a karst region of Southwest China.

Soil aggregates are crucial for reducing soil erosion and enhancing soil organic carbon sequestration. However, knowledge regarding influences of different slope positions on compositions and carbon content for different soil aggregates is limited. Soil samples were collected from various slope positions including dip slope, anti-dip slope and valley depression in the Longtan karst valley of Southwest China.

Droplet-Based Direct-Current Electricity Generation Induced by Dynamic Electric Double Layers.

Harvesting energy from water droplets has received tremendous attention due to the pursuit of sustainable and green energy resources. The droplet-based electricity generator (DEG) provides an admirable strategy to harvest energy from droplets into electricity. However, most of the DEGs merely generate electricity of alternating current (AC) output rather than direct current (DC) without the utilization of rectifiers, impeding its practical applications in energy storage and power supply.

Hierarchical porous dual-mode thermal management fabrics achieved by regulating solar and body radiations.

Personal thermal management (PTM) of fabrics is vital for human health; the ever-changing location of the human body poses a big challenge for fabrics to maintain a favorable metabolic temperature. Herein, a dual-mode thermal management fabric is designed to achieve both cooling and heating functions by regulating simultaneously solar and body radiations. The cooling or heating mode can be exchanged by flipping the fabric without an external energy supply.

Factors influencing college students' self-regulated learning in online learning environment: A systematic review.

Objective: Drawing on the control value theory, this study aims to identify the pertinent factors of self-regulated learning in the online learning environment for college students. The analysis will inductively examine how these factors impact self-regulated learning, thereby furnishing a reference for educators and online learning platform developers to create more efficacious online learning and teaching modes.

Design: Systematic review.

A nomogram for intraoperatively predicting non-sentinel lymph node metastases in early breast cancer patients with positive sentinel lymph nodes.

Background: Individualized decisions are required in early-stage breast cancer patients. We aimed to establish a novel model for predicting non-sentinel lymph node (SLN) metastases in patients with positive SLNs, using preoperative and intraoperative characteristics and inflammatory indicators.

Methods: The data of 489 patients with invasive breast cancer were retrospectively collected from Xuanwu Hospital between 2014 and 2021.

Degradation of micropollutants in flow-through VUV/UV reactors: Impact of internal diameter and baffle allocation.

Application of VUV/UV process for micropollutants removal in decentralized water supply systems (e.g., rural drinking water treatment) is promising while few researches by far paid attention to the performance of practical flow-through reactors.

Case-based learning interventions for undergraduate nursing students in a theoretical course: A review of design, implementation, and outcomes.

Background: Case-based learning (CBL) is a contextualized learning and teaching method that can facilitate active and reflective learning to develop critical thinking and problem-solving skills. However, nursing educators have some difficulty in creating a CBL environment that matches the diverse professional nursing curriculum and students' needs, including developing relevant cases and appropriate CBL implementation processes.

Objective: To summarize the case design, implementation process, and their relationship with CBL effectiveness.

Factors influencing adherence to healthy eating behaviors among adult colorectal cancer survivors: a systematic mixed method review.

Purpose: Under the umbrella of social cognitive theory, we examined the influences of personal, environmental, and behavioral factors on adherence to healthy eating behaviors among colorectal cancer survivors.

Methods: Based on Pluye and Hong's framework, a systematic mixed studies review was conducted. An extensive search strategy was applied in PubMed, Web of Science, Embase, CINAHL, and PsycINFO (from date of record to 2022 January 22).

A new magnetic ionic liquid based salting-out assisted dispersive liquid-liquid microextraction for the determination of parabens in environmental water samples.

In this study, a new magnetic ionic liquid (MIL) was designed and prepared, containing a magnetic cation from the ligand ,-dimethyl biguanide (DMBG) complexing with magnetic center Co and a bis-trifluoromethanesulfonimide (NTf) anion. Using the MIL as the extraction solvent, a salting-out assisted dispersive liquid-liquid microextraction (SA-DLLME) combined with high performance liquid chromatography-ultraviolet detection (HPLC-UV) was established for the enrichment and detection of four parabens in environmental water samples. The one-factor-at-a-time experiment was employed to optimize the conditions affecting the extraction efficiency.

Degradation of micropollutants in flow-through UV/chlorine reactors: Kinetics, mechanism, energy requirement and toxicity evaluation.

The degradation of three micropollutants (i.e., atrazine (ATZ), sulfamethoxazole (SMX) and metoprolol (MET)) was comprehensively investigated in flow-through UV/chlorine reactors.

Bioinspired soft electroreceptors for artificial precontact somatosensation.

Artificial haptic sensors form the basis of touch-based human-interfaced applications. However, they are unable to respond to remote events before physical contact. Some elasmobranch fishes, such as seawater sharks, use electroreception somatosensory system for remote environmental perception.

Electricity Generation and Self-Powered Sensing Enabled by Dynamic Electric Double Layer at Hydrogel-Dielectric Elastomer Interfaces.

The electric double layer (EDL) at liquid-solid interfaces is fundamental to many research areas ranging from electrochemistry and microfluidics to colloidal chemistry. Here, we demonstrate the electricity generation by mechanically modulating the EDL at the hydrogel-dielectric polymer interfaces. It is found that contact electrification between the hydrogel and the dielectric polymer could charge the dielectric polymer surface at first; the mechanical deformation of the pyramid-shaped hydrogel results in the periodic variation of the EDL area and capacitance, which then induces an alternative current in the external circuits.

Development and validation of a novel 14-gene signature for predicting lymph node metastasis in papillary thyroid carcinoma.

Background: There is still no reasonably accurate method of preoperatively predicting central lymph node metastasis (LNM), and it is essential to develop an effective evaluation model for predicting LNM in papillary thyroid carcinoma (PTC) patients.

Methods: PTC samples were collected from The Cancer Genome Atlas database. Candidate genes were identified as continuously upregulated or downregulated genes in the process of N0 to N1a and N1a to N1b.

Triboelectric-optical responsive cholesteric liquid crystals for self-powered smart window, E-paper display and optical switch.

Intelligent responsive devices are crucial for a variety of applications ranging from smart electronics to robotics. Electro-responsive cholesteric liquid crystals (CLC) have been widely applied in display panels, smart windows, and so on. In this work, we realize the mechanical stimuli-triggered optical responses of the CLC by integrating it with a triboelectric nanogenerator (TENG), which converts the mechanical motion into alternating current electricity and then tunes the different optical responses of the CLC.

Carbon nanoparticle-guided intraoperative lymph node biopsy predicts the status of lymph nodes posterior to right recurrent laryngeal nerve in cN0 papillary thyroid carcinoma.

Background: The lymph nodes in the right central compartment can be divided into 2 parts by the right recurrent laryngeal nerve (RLN), and there is a lack of an accurate and convenient method for assessing metastases in the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) in cN0 thyroid papillary carcinoma patients.

Methods: Patients diagnosed with cN0 thyroid papillary carcinoma and underwent intraoperative carbon nanoparticle-guided lymph node biopsy from January 2017 to November 2020 at the Center for Thyroid and Breast Surgery of Xuanwu Hospital were retrospectively analyzed. The intraoperative frozen section examination and postoperative LN-prRLN status should have been comprehensively recorded.

A 10-Gene Signature for Predicting the Response to Neoadjuvant Trastuzumab Therapy in HER2-Positive Breast Cancer.

Background And Purpose: Dual-target therapy may increase the incidence of adverse events and cause economic burden to patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer. It is necessary to identify the patients who could benefit greatly from a single-target neoadjuvant therapy in order to avoid overtreatment of patients.

Patients And Methods: The baseline transcriptome data and clinical characteristics of patients with HER2-positive breast cancer who received neoadjuvant trastuzumab therapy were obtained from the Gene Expression Omnibus database.