Publications by authors named "LuYang Jiang"
Article Synopsis
- Researchers are studying how combining immunotherapy and radiotherapy (RT) affects cancer tumors, especially focusing on the tumor's environment and immune response.
- They collected tumor samples from a patient with stomach cancer to see how different types of cells changed during RT using special techniques.
- Their findings showed that while RT increases some immune cells, it also lowered the presence of others, suggesting careful planning is needed for effective cancer treatments combining RT and immunotherapy.
Background: Ball thrombus is rare and life-threatening. The correct diagnosis and timely management are key to improving patient prognosis. Here, we present a case report and literature review of ball thrombus.
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- This study investigates the effectiveness of immune checkpoint blockades combined with chemotherapy in metastatic gastric cancer (mGC) and introduces a TMEscore model to evaluate the tumor microenvironment (TME) as a potential biomarker for treatment response.* -
- A total of 86 tumor samples were analyzed from patients in a multi-center trial, showing that a higher TMEscore correlated with better treatment responses (31.4% overall response rate), with TMEscore-high patients achieving a 59% response rate and improved survival outcomes.* -
- The TMEscore outperformed other biomarkers like MSI and CPS for predicting patient responses, indicating its potential as a reliable tool for identifying mGC patients who could benefit from ICB and
Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress-inflammation vicious cycle and complicated intercellular crosstalk within the ocular microenvironment. Here, a nanozyme-based eye drop, namely nanoceria loading cyclosporin A (Cs@P/CeO), is developed, which possesses long-term antioxidative and anti-inflammatory capacities due to its regenerative antioxidative activity and sustained release of cyclosporin A (CsA).
View Article and Find Full Text PDFCholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments. The regulation of cholesterol metabolism in the human is an extremely complex process.
View Article and Find Full Text PDFA new class of noncoding RNAs, tsRNAs are not only abundant in humans but also have high tissue specificity. Recently, an increasing number of studies have explored the correlations between tsRNAs and tumors, showing that tsRNAs can affect biological behaviors of tumor cells, such as proliferation, apoptosis and metastasis, by modulating protein translation, RNA transcription or posttranscriptional regulation. In addition, tsRNAs are widely distributed and stably expressed, which endows them with broad application prospects in diagnosing and predicting the prognosis of tumors, and they are expected to become new biomarkers.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is a highly invasive cancer with a poor prognosis and a 5-year survival rate of less than 11%. As a member of the CAP superfamily of proteins, the role of peptidase inhibitor 16 (Pi16) in tumor progression is still unclear. Immunohistochemistry and quantitative RT-PCR methods were used to detect the expression levels of Pi16 protein and mRNA in PDAC patients.
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- The term "ghost" describes fibrous tissue left in the heart after implanted device leads are removed, as seen in a 75-year-old male post-transvenous lead extraction due to infection.
- After the procedure, transesophageal echocardiography identified a stable "ghost" in the right atrium with one end attached to the wall and the other moving freely.
- The evaluation confirmed the "ghost" was benign, highlighting the need to distinguish between such entities and true medical issues to avoid unnecessary treatments.
Objectives: Pecto-intercostal fascial block (PIFB) and rectus sheath block (RSB) have been combined to offer better analgesia for cardiac surgery patients, but safety of the analgesic protocol with a large volume of ropivacaine is uncertain.
Methods: This is a prospective observational study at Peking University People's Hospital to investigate the pharmacokinetic profile of ropivacaine after combined regional blocks. Patients undergoing elective cardiac surgery by a median sternotomy were enrolled to receive bilateral PIFB and RSB with 70 mL 0.
Background: Perioperative newly developed left atrial appendage (LAA) thrombus is a rare but extremely challenging event for anesthesia management. It's important to identify and diagnose thrombosis in high-risk populations promptly.
Case Presentation: In the case of an elderly patient with atrial fibrillation undergoing non-cardiac surgery, we recorded the findings before and after thrombosis during the operation using transesophageal echocardiography (TEE).
Introduction: Chronic postoperative pain poses challenges, emphasizing the importance of accurately predicting pain in advance. Generally, pain perception is associated with the temporal dynamics of the brain, which can be represented by microstates. Specifically, microstates are transient and patterned brain topographies formed by temporally overlapping and spatially synchronized oscillatory activities.
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- The study investigated the effectiveness of two different training methods for flexible optical bronchoscopic (FOB) intubation among anesthesiology residents: one based on individual learning curves and the other with a fixed one-hour training time.
- Participants (32 in total) were split equally into two groups, and results showed that the learning curve-based group had a mean intubation time of 81.9 seconds, while the fixed time group had a mean time of 97.0 seconds.
- The findings indicated that the new training method was just as effective as the fixed method, with trainees taking an average of only 28.4 minutes to complete their training, significantly less than the one-hour fixed time.
Objective: Postoperative pulmonary complications are a series of disorders that can contribute to respiratory distress and prolonged mechanical ventilation postoperatively. We hypothesise that a liberal oxygenation strategy during cardiac surgery leads to a higher incidence of postoperative pulmonary complications than a restrictive oxygenation strategy.
Methods: This study is a prospective, observer-blinded, centrally randomised and controlled, international multicentre clinical trial.
Article Synopsis
- - The study evaluated the predictive ability of the superior vena cava collapsibility index (SVC-CI) against stroke volume variation (SVV) in mechanically ventilated patients undergoing elective surgery, with 60 patients receiving fluid challenges.
- - Results showed that 48% of patients were fluid responders (FR), with a significantly higher SVC-CI in this group compared to non-responders (NR), and strong correlation found between SVC-CI and changes in cardiac index (△CI).
- - The study concluded that SVC-CI is more effective than SVV in predicting fluid responsiveness, while the E/e' ratio and central venous pressure (CVP) were not useful for this purpose.
Objectives: Epidural and paravertebral block reduce the extubation time in patients undergoing surgery under general anesthesia but are relatively contraindicated in heparinized patients due to the potential risk of hematoma. The Pecto-intercostal fascial block (PIFB) is an alternative in such patients.
Methods: This is a single-center randomized controlled trial.
Background: Pecto-intercostal fascial block (PIFB) provides analgesia for cardiac median sternotomy, but many patients complain of severe drainage pain that cannot be covered by PIFB. Rectus sheath block (RSB) has been attempted to solve this problem, but whether PIFB combined with RSB can achieve better analgesia is uncertain.
Methods: This was a single-center randomized controlled trial at Peking University People's Hospital from September 22, 2022 to December 21, 2022.
The clinical role of transesophageal echocardiography during transvenous lead extraction.
Echocardiography
September 2021
Article Synopsis
- Transesophageal echocardiography (TEE) is used during transvenous lead extraction (TLE) procedures, but its specific role and benefits need further clarification.
- A study reviewed 195 high-risk patients who underwent TLE, comparing outcomes between those monitored with TEE and those without, finding no significant differences in success rates or complications.
- Although TEE didn't change procedural success or complication rates, it helped in planning surgeries, guiding treatments, and diagnosing issues quickly, thereby enhancing patient safety.
Background: Ventricular septal rupture (VSR) is a rare but lethal complication occurring after acute myocardial infarction. The aim of our study was to review the single-center experience of surgery for VSR and seek a comprehensive evaluation process for early mortality.
Methods: Patients undergoing surgical repair for postinfarction VSR in our institution retrospectively were evaluated from Jan.
Background: Von Hippel-Lindau disease (also known as VHL syndrome), is an autosomal dominant inherited disease. We describe a sporadic case of VHL syndrome where bilateral pheochromocytomas were unexpectedly identified. The patient underwent selective laparoscopic resections of the pheochromocytomas, and the anesthetic management during surgery was complex and challenging.
View Article and Find Full Text PDFAn Unusual Left Ventricular Finding in a Patient With Bicuspid Aortic Valve Stenosis.
J Cardiothorac Vasc Anesth
December 2017
Article Synopsis
- Tricuspid annuloplasty may be beneficial before significant tricuspid regurgitation occurs, as changes in the tricuspid annulus can indicate reversible right ventricular dysfunction.
- *3D echocardiographic data from 26 patients showed significant variations in the tricuspid annulus's size and shape throughout the cardiac cycle, particularly in the anterolateral and anteroseptal regions.
- *Understanding the dynamic behavior of the tricuspid annulus is crucial for designing effective annuloplasty devices and improving treatment outcomes.*
Dynamism of the mitral annulus: a spatial and temporal analysis.
J Cardiothorac Vasc Anesth
October 2014
Article Synopsis
- The study investigated how the mitral annular area changes during the cardiac cycle, focusing on whether these changes occur mainly in the posterior part or are more global.
- Using 3D transesophageal echocardiography, researchers analyzed data from 26 patients to measure annular areas and diameters throughout different phases of the cardiac cycle.
- Results showed that both anterior and posterior parts of the mitral annulus undergo significant changes during systole and diastole, with minimal changes in the intertrigonal distance over the cycle.