Establishment and characterization of a new intestinal-type ampullary carcinoma cell line, DPC-X3.

Ampullary carcinoma (AC) of the intestinal type represents a distinct variant within the broader category of ampullary neoplasms. The scarcity of pertinent cellular models has constrained investigations centered on this particular malignancy. This research effectively generated a cell line (CL) of intestinal-type AC (DPC-X3).

Important functions and molecular mechanisms of aquaporins family on respiratory diseases: potential translational values.

Aquaporins (AQPs) are a subgroup of small transmembrane transporters that are distributed in various types of tissues, including the lung, kidney, heart and central nervous system. It is evident that respiratory diseases represent a significant global health concern, with a considerable number of deaths occurring worldwide. Recent researches have demonstrated that AQPs play a pivotal role in respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS), and particularly non-small cell lung cancer (NSCLC).

PPAR-γ/NF-kB/AQP3 axis in M2 macrophage orchestrates lung adenocarcinoma progression by upregulating IL-6.

Aquaporin 3 (AQP3), which is mostly expressed in pulmonary epithelial cells, was linked to lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of AQP3 in the tumor microenvironment (TME) of LUAD have not been elucidated. Single-cell RNA sequencing (scRNA-seq) was used to study the composition, lineage, and functional states of TME-infiltrating immune cells and discover AQP3-expressing subpopulations in five LUAD patients.

Visible-Light Photocatalytic Degradation Efficiency of Tetracycline and Rhodamine B Using a Double Z-Scheme Heterojunction Catalyst of UiO-66-NH/BiOCl/BiS.

BiOCl is a promising photocatalyst, but due to its weak visible light absorption capacity and low photogenerated electron-hole pair separation rate, its practical application is limited to a certain extent. In this study, a novel double Z-scheme heterojunction UiO-66-NH/BiOCl/BiS catalyst was constructed to broaden the visible light response range and promote high photogenerated hole-electron separation of BiOCl. Its photocatalytic performance is evaluated by dissociating tetracycline (TC) and rhodamine B (RhB) in visible light.

Establishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1.

Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and developing novel drugs to improve clinical outcomes. Here, a novel pancreatic cancer cell line, PDAC-X1, derived from Chinese patients has been established.

Anchored VN Quantum Dots Boosting High Capacity and Cycle Durability of NaV(PO)@NC Cathode for Aqueous Zinc-Ion Battery and Organic Sodium-Ion Battery.

NaV(PO) is a promising high-voltage cathode for aqueous zinc-ion batteries (ZIBs) and organic sodium-ion batteries (SIBs). However, the poor rate capability, specific capacity, and cycling stability severely hamper it from further development. In this work, NaV(PO) (NVP) with vanadium nitride (VN) quantum dots encapsulated by nitrogen-doped carbon (NC) nanoflowers (NVP/VN@NC) are manufactured as cathode using in situ nitridation, carbon coating, and structural adjustment.

Flexible free-standing Fe-CoP-NAs/CC nanoarrays for high-performance full lithium-ion batteries.

In this study, a flexible, free-standing Fe-doped CoP nanoarrays electrode for superior lithium-ion storage has been successfully fabricated. The electrode combines the advantages of a Fe-doping and a flexible carbon cloth (CC) support, resulting in a high specific capacity (1356 mAh/g at 0.2 A/g) and excellent cycling stability (1138 mAh/g after 100 cycles).

Effects of acupuncture at myofascial trigger points combined with sling exercise therapy on clinical recovery and cervical spine biomechanics in patients with cervical spondylotic radiculopathy.

Objective: This research aimed to ascertain the effects of acupuncture at myofascial trigger points (MTrPs) in combination with sling exercise therapy (SET) on the clinical recovery and cervical spine biomechanics in patients with cervical spondylotic radiculopathy (CRS).

Methods: Eighty patients with CSR were divided into Group A and Group B. Group A was treated with acupuncture at MTrPs, and Group B was treated with acupuncture at MTrPs combined with SET.

Recyclable fabrication of hollow N-doped amorphous carbon nanospindles with abundant short-range curved carbon fragments as bifunctional anode for lithium/sodium ion storage.

A recyclable hard-template method is proposed to exploit spindle-shaped hollow nitrogen-doped amorphous carbon (h-NAC) with a large number of short-range curved carbon fragments as anodes for lithium/sodium ion batteries (LIBs/SIBs). Besides providing adsorption sites due to the high existence of oxygen-containing functional groups (CO and COOH), the heavily exposed edge regions also provide a favorable storage environment with high adsorption energy for Li/Na due to their short-range curved structure. Importantly, the etching solution of hard templates can be recycled to generate the FeOOH nanospindles as a precursor through a simple chemical titration, which supplies a new idea for the green preparation of hollow materials.

FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.

Objective: Fucosyltransferases (FUTs) molecules have been identified to be involved in carcinogenesis of malignant tumors. Nevertheless, the biological function of fucosyltransferases-3 (FUT3) in lung adenocarcinoma (LUAD) malignant phenotype remains unclear. Herein, we investigated the association between FUT3 and LUAD pathological process.

Oxygen defects engineering and structural strengthening of hydrated vanadium oxide cathode by coating glucose hydrothermal carbon and pre-embedding Mn (II) ion for high-capacity aqueous zinc ion batteries.

Vanadium oxide-based cathode with unique layered structure is considered as a candidate for aqueous zinc ion batteries (AZIBs). Unfortunately, considering poor electronic conductivity, sluggish diffusion kinetics, and the destruction of layered structures in the cycling process, the actual capacity and rate capability are constrained. Herein, the glucose hydrothermal carbon (GHC) and transition metal Mn ion have been utilized to incorporate hydrated vanadium oxide (Mn-VOH@GHC).

The Landscape of Lipid Metabolism in Lung Cancer: The Role of Structural Profiling.

The aim of this study was to explore the relationship between lipids with different structural features and lung cancer (LC) risk and identify prospective biomarkers of LC. Univariate and multivariate analysis methods were used to screen for differential lipids, and two machine learning methods were used to define combined lipid biomarkers. A lipid score (LS) based on lipid biomarkers was calculated, and a mediation analysis was performed.

Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma.

Background: DERL3 has been implicated as an essential element in the degradation of misfolded lumenal glycoproteins induced by endoplasmic reticulum (ER) stress. However, the correlation of DERL3 expression with the malignant phenotype of lung adenocarcinoma (LUAD) cells is unclear and remains to be elucidated. Herein, we investigated the interaction between the DERL3 and LUAD pathological process.

KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway.

Non-small cell lung cancer (NSCLC) is a primary histological subtype of lung cancer with increased morbidity and mortality. K channels have been revealed to be involved in carcinogenesis in various malignant tumors. However, TWIK-related acid-sensitive potassium channel 1 (TASK-1, also called KCNK3), a genetic member of K2P channels, remains an enigma in lung adenocarcinoma (LUAD).

Super-Coordinated Nickel N Ni O Site Single-Atom Catalyst for Selective H O Electrosynthesis at High Current Densities.

Electrochemical production of hydrogen peroxide (H O ) from O on single-atom catalysts has attracted great attention, yet the quest for robust catalysts is driven by achieving >90 % Faradaic efficiency (FE) under industrial-relevant current densities (>100 mA cm ). Herein we synthesize a catalyst that contains single nickel site coordinated by four nitrogen and two oxygen atoms (i.e.

Hollow nanospheres constructed by ultrafine few-layered MoS partially with amorphous fragments homogeneously incorporated in N-doped amorphous carbon for enhanced lithium storage performance.

The rational design of ultrathin and few-layered structures for three-dimensional MoS nanospheres is crucial for achieving attractive lithium-ion batteries (LIBs). Herein, hollow nanospheres constructed by ultrafine and few-layered MoS homogeneously incorporated in N-doped amorphous carbon (HUF-MoS/NC) have been successfully synthesized as high-performance anode for LIBs. Using Mo-glycerol spheres as templates and dopamine hydrochloride as coordination ligands, hollow Mo-glycerol-polydopamine precursors are formed with Mo-containing groups which are surrounded by organic carbon species.

Dynamic Characteristics and Experimental Research of Linear-Arch Bi-Stable Piezoelectric Energy Harvester.

Collecting vibration energy in the environment is expected to solve the problem of the self-power supply of wireless monitoring nodes in underground coal mines. By introducing nonlinear factors, a linear-arch bi-stable piezoelectric energy harvester (LBPEH) is designed. In order to reveal the influence of system parameters on the dynamic characteristics of LBPEH, the magnetic force model is established by the magnetizing current method, and the restoring force model is acquired through experimental measurement.

Suppression of MIR31HG affects the functional properties of thyroid cancer cells depending on the miR-761/MAPK1 axis.

Background: Thyroid cancer is the most prevalent endocrine malignancy. Long non-coding RNA (lncRNA) MIR31HG is abnormally expressed in thyroid cancer tissues. However, the precise, critical role of MIR31HG in thyroid cancer development remains unclear.

A Method for Parameter Identification of Composite Beam Piezoelectric Energy Harvester.

This paper proposes a parameter identification method for the multiparameter identification study of the linear-arch composite beam piezoelectric energy harvester. According to the voltage response characteristics of the system under short-circuit conditions, the mechanical equation is solved by transient excitation, combined with the backbone curve theory and logarithmic attenuation method, to obtain the system's linear damping, linear stiffness, and nonlinear stiffness. According to the voltage response characteristics of the system under open-circuit conditions, combined with the electrical equations, the system electromechanical coupling coefficient and equivalent capacitance coefficient are obtained; numerical simulation results show that the identification parameters have good accuracy.

Comprehensive Analysis of Aquaporin Superfamily in Lung Adenocarcinoma.

Lung adenocarcinoma (LUAD) is the most predomintnt lung cancer subtype with increasing morbidity and mortality. Previous studies have shown that aquaporin (AQP) family genes were correlated with tumor progression and metastasis in several kinds of malignancies. However, their biological behaviors and prognostic values in LUAD have not been comprehensively elucidated.

Time-Domain Dynamic Characteristics Analysis and Experimental Research of Tri-Stable Piezoelectric Energy Harvester.

In order to explore the dynamic characteristics of the linear-arch beam tri-stable piezoelectric energy harvester (TPEH), a magnetic force model was established by the magnetic dipole method, and the linear-arch composite beam nonlinear restoring force model was obtained through experiments. Based on the Euler-Bernoulli beam theory, a system dynamic model is established, and the influence of the horizontal distance, vertical distance and excitation acceleration of magnets on the dynamic characteristics of the system is simulated and analyzed. Moreover, the correctness of the theoretical results is verified by experiments.

Multi-Task Classification and Segmentation for Explicable Capsule Endoscopy Diagnostics.

Capsule endoscopy is a leading diagnostic tool for small bowel lesions which faces certain challenges such as time-consuming interpretation and harsh optical environment inside the small intestine. Specialists unavoidably waste lots of time on searching for a high clearness degree image for accurate diagnostics. However, current clearness degree classification methods are based on either traditional attributes or an unexplainable deep neural network.

A Curve-Shaped Beam Bistable Piezoelectric Energy Harvester with Variable Potential Well: Modeling and Numerical Simulation.

To improve the energy harvesting performance of an energy harvester, a novel bistable piezoelectric energy harvester with variable potential well (BPEH-V) is proposed by introducing a spring to the external magnet from a curve-shaped beam bistable harvester (CBH-C). First, finite element simulation was performed in COMSOL software to validate that the curved beam configuration was superior to the straight beam in power generation performance, which benefits energy harvesting. Moreover, the nonlinear magnetic model was obtained by using the magnetic dipoles method, and the nonlinear restoring force model of the curve-shaped beam was acquired based on fitting the experimental data.