Anion-π Type Polymeric Nanoparticle Dispersants for Enhancing the Dispersion Stability of Organic Pigments in Water.

High-performance water-based inkjet inks are critical for advancing inkjet printing technology. The performance of water-based inkjet inks depends largely on the dispersion stability of organic pigments. This imposes higher demands on the performance of polymeric dispersants.

Six Chinese patients with propionic acidemia: from asymptomatic to death in the neonatal period.

Background: Propionic acidemia (PA) is a severe organic acidemia that can result in multi-organ damage and is potentially fatal. The rarity of this disease and the limited number of reported cases contribute to a lack of comprehensive knowledge, particularly concerning the genotype-phenotype correlation. This study aims to report on PA cases in Beijing and Ningxia, China, identify the pathogenic genetic factors involved, and explore the relationship between genotype and phenotype.

Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II.

In adaptive immunity, transcription-coupled damage (TCD) is introduced into antibody genes by activation-induced cytidine deaminase (AID) to diversify antibody repertoire. However, the coordination between transcription and DNA damage/repair remains elusive. Here, we find that transcription elongation factor 1 (ELOF1) stabilizes paused RNA polymerase II (RNAPII) at transcription barriers, providing a platform for transcription-coupled DNA damage/repair.

A strategy for electrochemical biosensing based on dendritic HCR amplification for detection of RNA m5C and m6A methylation.

Sensitive and efficient detection of RNA methylation sites is considered an integral part of epigenetic assessment. Contrary to previous studies on the detection of RNA m5C or m6A methylation alone, this study innovatively designed a biosensor capable of detecting RNA m5C or m6A methylation at the same time. Substances with specific electrochemical reactions such as ferrocene (FC) or methylene blue (MB) were modified onto the hairpin probe.

A novel photoelectrochemical strategy for ultrasensitive and simultaneous detection of 5-methylcytosine and N6-methyladenosine based on proximity binding-triggered assembly MNAzyme -mediated HRCA.

The preparation of UiO-66@CdTe@AuNPs composites is presented for the first time, which function as a photoelectrochemical (PEC) sensing matrix and are conjugated to a three-way junction (TWJ). We propose an antibody-based specific recognition-induced neighbor-joining reaction that initiates the assembly of two molecularly designed nucleic acid enzymes (MNAzymes), to release an oligonucleotide that hydrolyzes TWJ through the mechanism of a toehold-mediated strand displacement reaction (TSDR). Subsequently, a hybridization chain reaction application (HRCA)-based dendrimer is formed, which immobilizes a large number of quantum dots to generate a burst effect that reduces the photocurrent signal.

Electrochemical epoxidation enhanced by CH activation and hydroxyl generation at the Ag/SnO interface.

Direct electrochemical ethylene (CH) epoxidation with water (HO) represents a promising approach for the production of value-added ethylene oxide (EO) in a sustainable way. However, the activity remains limited due to the sluggish activation of CH and the stiff formation of *OH intermediate. This paper describes the design of a Ag/SnO electrocatalyst to achieve efficient electrochemical CH epoxidation with a high faradaic efficiency of 39.

Up-regulation of mA writer METTL14 inhibits tumorigenesis by suppressing glycolysis in colorectal cancer.

Background: Colorectal cancer (CRC) is a common malignant tumor. N-Methyladenosine (mA) modification plays an important role in the regulation of glycolysis in tumor cells and may be a potential target for tumor therapy.

Methods: The role of METTL14, an mA writer, in CRC was investigated through functional assays including cell viability, colony formation, and glycolysis-related measurements (glucose uptake, lactate production, extracellular acidification rate (ECAR) and oxygen consumption rate (OCR)).

Lightweight DCGAN and MobileNet based model for detecting X-ray welding defects under unbalanced samples.

X-ray nondestructive testing technology is widely used for inspecting welds and identifying defects, and is crucial in the manufacturing industry. However, the diversity of welding defects and the imbalanced defect samples reduce defect classification model accuracy and can cause classifier overfitting. This paper proposes an improved DCGAN model for generating welding defect samples by integrating deep convolutional neural networks to enhance the training relationship between the generator and discriminator, thus increasing the number of training samples.

Origin of Autocatalytic Behavior of Water over CuZn Alloy in CO Hydrogenation.

Water plays a significant role in CO hydrogenation, which is capable of accelerating the reaction in an autocatalytic manner, but the reason for water promotion in the system is still controversial. This work dissects the mechanisms behind the autocatalytic behavior of water in CO hydrogenation. Based on the stable structure of CuZn(211) alloy under the reaction condition, density functional theory is employed to systematically explore all possible autocatalytic modes of water.

OUFR Versus FFR for Functional Assessment of Coronary Artery Stenosis in Patients With Unstable Angina.

Background: Hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) imaging can integrate both advantages. Optical ultrasonic flow ratio (OUFR) was recently developed for functional assessment.

Objectives: This study aimed to verify the diagnostic performance of OUFR using fractional flow reserve (FFR) as the reference standard.

Functional or anatomical assessment of non-culprit lesions in acute myocardial infarction.

Background: Previous studies have reported the value of quantitative flow ratio (QFR) to assess the physiological significance of non-culprit lesions (NCLs) in acute myocardial infarction (AMI) patients and of optical coherence tomography (OCT)-defined thin-cap fibroatheroma (TCFA) to identify non-culprit vulnerable plaques.

Aims: We sought to systematically compare long-term NCL-related clinical prognosis in an AMI population utilising acute Murray fractal law-based QFR (μQFR) values and OCT-defined TCFA.

Methods: Three-vessel OCT imaging and μQFR assessment were conducted in 645 AMI patients, identifying 1,320 intermediate NCLs in non-infarct-related arteries.

Selection and evaluation of reference genes for qRT-PCR in .

Real-time quantitative reverse transcription PCR (RT-qPCR) is one of the most effective tools for studying gene expression. is a rare and edible medicinal fungus. Selecting an appropriate reference gene is crucial for researching its gene function.

Dual-Network MXene/Polyurethane Composite Foams for Both Stretchable and Compressible Electromagnetic Interference Shielding and Strain Sensors.

Miniaturized and wearable electronic products require electromagnetic interference shielding (EMI) materials with sensing functions to cope with complex application situations. Herein, an effective dual-network structure is designed to fabricate two-dimensional transition metal carbides and nitrides/bacterial cellulose-thermoplastic polyurethane (MXene/BC-TPU) foams with intriguing EMI shielding property and piezoelectric sensing ability under both compressive and tensile strains. Anisotropic MXene/BC aerogels, as conductive networks, with impressive conductivity (1912 S m), ultrahigh EMI shielding effectiveness (SE) of 86 dB, and absolute SE up to 63,608 dB cm g can be built by directional freezing.

Evolutionary-Distinct Viral Proteins Subvert Rice Broad-Spectrum Antiviral Immunity Mediated by the RAV15-MYC2 Module.

A variety of plant viruses employ different virulence strategies to achieve successful infection, resulting in abnormal plant development. However, the common pathogenicity of distinct viruses has rarely been studied. Here, it is shown that a plant-specific RAV-type transcription factor, OsRAV15, is specifically targeted by several distinct viral proteins for facilitating viral infection.

Long-Term Prognostic Implications of Non-Culprit Lesions in Patients Presenting With an Acute Myocardial Infarction: Is It the Angiographic Stenosis Severity or the Underlying High-Risk Morphology?

Background: Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether events are due to stenosis severity or due to the underlying high-risk lesion morphology.

Methods: Between January 2017 and December 2021, 1312 patients with acute myocardial infarction underwent optical coherence tomography of all the 3 main epicardial arteries after successful percutaneous coronary intervention.

Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism.

This study investigates the potential of ionic liquids (ILs) as sustainable solvents in ultrasonic-assisted extraction (UAE) to efficiently recover luteolin from peanut shells. Among the range of ILs tested, 1-butyl-3-methylimidazolium tetrafluoroborate stood out as the most effective solvent, achieving the highest extraction yield. Single-factor experiments were conducted to analyze the effects of ultrasonic power, extraction time, extraction temperature, IL concentration, and solid-to-liquid ratio on extraction efficiency.

Structural Optimization of Natural Plant Products: Construction, Pesticidal Activities, and Toxicology Study of New 2-Isopropanol-4-methoxy-7-alkyl/aryloxycarbonyl-()-vinyl-2,3-dihydrobenzofurans.

Recently, the structural optimization of natural bioactive products has been one of the important ways to discover new pesticide candidates. Based on osthole as a lead compound, herein, a series of new 2-isopropanol-4-methoxy-7-alkyl/aryloxycarbonyl-()-vinyl-2,3-dihydrobenzofuran derivatives were synthesized. Steric configurations of compounds , , , , , , and were confirmed by X-ray monocrystallography.

Characterization and Transcriptional Regulation of the 2-Ketogluconate Utilization Operon in .

JUIM01 is an industrial 2-keto-d-gluconate (2KGA)-producing strain. However, its regulation mechanism of 2KGA metabolism remains to be clarified. Among other reported species, the 2-ketogluconate utilization operon ( operon) plays key roles in 2KGA catabolism.

Antifungal Resistance Patterns of Microsporum canis: A 27-Year MIC Study in Mainland China.

Background: Microsporum canis, a dermatophyte commonly associated with pets, is a leading cause of severe tinea capitis. The increasing prevalence of antifungal resistance among dermatophytes poses a significant global health challenge.

Objectives: This study aims to define the updated antifungal susceptibility profile of M.

Preliminary study of the role of inner ear proteins in vestibular neuritis.

Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.

Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension.

Circadian rhythm pattern of symptom onset in patients with ST-segment elevation myocardial infarction in the Chinese population.

Background: The peak incidence of cardiovascular diseases (CVD) usually occurs in the morning. This study aimed to investigate the exact distribution pattern of peak incidence of ST-segment elevation myocardial infarction (STEMI) in the Chinese population, and to explore whether it is associated with the prognosis.

Methods: This study included 7,805 patients with STEMI from the multicenter, prospective AMI cohort in China, for whom had a definite time of symptom onset.

Microbe Engineering to Provide Drimane-Type Building Blocks for Chiral Pool Synthesis of Meroterpenoids.

Drimane-type merosesquiterpenoids (DMT) are a class of natural products with diverse structures and broad biological activity. Classical DMT synthesis relies on atom-inefficient plant-derived chiral pool building blocks, while alternative drimane-type building blocks such as drimenol and albicanol offer more direct routes but face production challenges. In this study, we engineered a microbial platform for efficient production of these building blocks.

Analysis of risk factor for peritonitis in peritoneal dialysis patients.

Objective: To investigate the risk factors for peritonitis in peritoneal dialysis patients and to develop and validate a predictive model.

Methods: A total of 219 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) who had their first peritoneal dialysis catheter placement and regular follow-up at Wuhan No. 1 Hospital between April 2020 and August 2023 were included in this study.