Exosomal miR-30a and miR-222 derived from colon cancer mesenchymal stem cells promote the tumorigenicity of colon cancer through targeting MIA3.

Background: Multipotent mesenchymal stem cells (MSCs) derived from virus tumors have been reported to contribute to malignant cell growth, invasion, and metastasis. However, the mechanism of communication between MSCs and colon cancer cells is poorly understood. Recent studies have suggested that exosomes are an important player in crosstalk between cells and could significantly suppress the invasion ability of human cancer cells (hCCs) when transfected with a microRNA inhibitor.

lncRNA SLC16A1-AS1 as a novel prognostic biomarker in non-small cell lung cancer.

Long non-coding RNAs (lncRNAs) have proved to act as crucial biomarkers in tumors. Novel biomarkers in non-small cell lung cancer (NSCLC) need to be investigated badly. To identify the differentially expressed lncRNAs between NSCLC tissue and adjacent tissue, microarray analysis was performed.

Translation and validation of the Chinese version of the Cancer Stigma Scale.

Purpose: To test the reliability and validity of the Chinese version of the Cancer Stigma Scale (CASS).

Methods: After translation, back-translation and cross-cultural adaptation of the CASS into Chinese (C-CASS), a random online survey of the general population in China was conducted. Reliability was analyzed by internal consistency (Cronbach's α) and construct validity was analyzed by confirmatory factor analysis.

Carbocisteine reduces the cytotoxicity of oxaliplatin.

Hepatic injury induced by oxaliplatin has been reported. Even though agents are available that reduce oxaliplatin-induced hepatocyte toxicity, their mode of action has remained obscure. In the present study, hepatic L02 cells were incubated with different combinations of oxaliplatin and carbocisteine.

Oxidative stress potentiated by diallylsulfide, a selective CYP2E1 inhibitor, in isoniazid toxic effect on rat primary hepatocytes.

Isoniazid (INH), one of the first-line antituberculosis drugs, has potential liver toxicity. Mechanisms reported by previous studies mainly focused on oxidative stress. In the present study, we investigated acute effects of diallylsulfide (DAS), a selective CYP2E1 inhibitor, on reduced glutathione (GSH) and reactive oxygen species (ROS) levels in rat primary hepatocytes treated with INH.