[Establishment and Identification of MDS Mouse Model with Irom Overload].

Objective: To establish a MDS mouse model with iron overload and to study the effect of iron overload on MDS.

Methods: The exogenous mutant gene RUNX1-S291fs was inserted into the mice bone marrow mononuclear cell's genome in mice by retrovirus and transplanted into C57BL/6 mice irradiated by Co γ-ray. After 8 weeks,intraperitoneal injection of iron was performed to establish an MDS mouse model with iron overload.