Publications by authors named "Lu-Qi Wei"

The discovery of nanoscale ferroelectricity in hafnia (HfO) has paved the way for next generation high-density, non-volatile devices. Although the surface conditions of nanoscale HfO present one of the fundamental mechanism origins, the impact of external environment on HfO ferroelectricity remains unknown. In this study, the deleterious effect of ambient moisture is examined on the stability of ferroelectricity using HfZrO (HZO) films as a model system.

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Neonicotinoid pesticides are a relatively new class of pesticides that have garnered significant attention owing to their potential ecological risks to nontarget organisms. A method combining solid phase extraction with liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) was developed for the rapid and accurate detection of eight neonicotinoid pesticides (dinotefuran, -nitenpyram, thiamethoxam, clothianidin, imidacloprid, imidaclothiz, acetamiprid, and thiacloprid) in wastewater. The chromatographic mobile phase and MS parameters were selected, and a single-factor method was used to determine the optimal column type, extraction volume, sample loading speed, and pH for SPE.

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Article Synopsis
  • Candidalysin, a toxin produced by Candida albicans, plays a crucial role in how the fungus causes disease, but its specific interactions with human proteins were not well understood until now.
  • Researchers used a high-throughput method to identify potential human protein targets of eight Ece1 peptides, discovering that CCNH, which is involved in DNA damage repair, interacts with candidalysin.
  • Candidalysin was found to increase the formation of double-strand DNA breaks by activating CCNH, disrupting the DNA repair pathway, which highlights how this fungal toxin may help the fungus persist in infections.
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  • Research identifies the presence of the fungus Aspergillus sydowii within tumors of lung adenocarcinoma (LUAD) patients, highlighting the significance of the intratumor mycobiome in cancer development.
  • Experiments on lung cancer mouse models show that A. sydowii accelerates tumor growth by activating certain immune cells (MDSCs) through the IL-1β signaling pathway, leading to weakened immune responses.
  • The study indicates that higher levels of A. sydowii in human tumors correlate with immune suppression and worse outcomes for patients, suggesting potential for targeting this fungus to improve treatment for LUAD.
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Human gut microbiome research, especially gut microbiome, has been developing at a considerable pace over the last decades, driven by a rapid technological advancement. The emergence of high-throughput technologies, such as genomics, transcriptomics, and others, has afforded the generation of large volumes of data, and in relation to specific pathologies such as different cancer types. The current review identifies high-throughput technologies as they have been implemented in the study of microbiome and cancer.

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() is an opportunistic human fungal pathogen that can cause severe infection in clinic. Its incidence and mortality rate has been increasing rapidly. Amphotericin B (AMB), the clinical golden standard antifungal agent, has severe side effects that limit its clinical application.

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The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract.

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Objective: To explore the clinical effect of rapid massage at Shuidao (ST 28) to prevent puerpera from postpartum urinary retention.

Methods: A total of 200 puerpera giving birth through vagina were enrolled and divided into an observation group and a control group according to the random number table method, 100 cases in each group. In the observation group, rapid massage at Shuidao (ST 28) was applied.

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