Advances in Stem Cell Therapies for Rotator Cuff Injuries.

Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains problematic, such as through failure of healing, adhesion formation, and fatty infiltration. Stem cells have high proliferation, strong paracrine action, and multiple differentiation potential, which promote tendon remodeling and fibrocartilage formation and increase biomechanical strength.

CRP, SAA, LDH, and DD predict poor prognosis of coronavirus disease (COVID-19): a meta-analysis from 7739 patients.

Understanding factors associated with disease severity and mortality from coronavirus disease (COVID-19) was critical for effective risk stratification. We aimed to investigate the association between biomarkers of clinical laboratory tests, including serum C-reactive protein (CRP), serum amyloid protein (SAA), lactate dehydrogenase (LDH), and D-dimer (DD) and poor prognosis of COVID-19. We have searched many studies on COVID-19 on PubMed (Medline), Web of Science and Cochrane until 1 March 2021.

Chameleon-Inspired Variable Coloration Enabled by a Highly Flexible Photonic Cellulose Film.

Due to spontaneous organization of cellulose nanocrystals (CNCs) into the chiral nematic structure that can selectively reflect circularly polarized light within a visible-light region, fabricating stretching deformation-responsive CNC materials is of great interest but is still a big challenge, despite such a function widely observed from existing creatures, like a chameleon, because of the inherent brittleness. Here, a flexible network structure is introduced in CNCs, exerting a bridge effect for the rigid nanomaterials. The as-prepared films display high flexibility with a fracture strain of up to 39%.

[Clinical analysis of denture-related oral mucosal lesions in 185 patients with removable denture].

Purpose: To investigate the category and prevalence rate of denture-related oral mucosal lesions (DML) in 185 patients with removable denture and analyze the influencing factors.

Methods: A total of 185 patients with removable denture who visited the department of stomatology of our hospital from October 2015 to June 2018 were investigated by questionnaire. DML types and locations were recorded in detail, and patients were followed up after treatment.

Possible aerosol transmission of COVID-19 and special precautions in dentistry.

Since its emergence in December 2019, corona virus disease 2019 (COVID-19) has impacted several countries, affecting more than 90 thousand patients and making it a global public threat. The routes of transmission are direct contact, and droplet and possible aerosol transmissions. Due to the unique nature of dentistry, most dental procedures generate significant amounts of droplets and aerosols, posing potential risks of infection transmission.

Dissecting the Genetic Architecture of Melon Chilling Tolerance at the Seedling Stage by Association Mapping and Identification of the Elite Alleles.

Low temperature is an important abiotic stress that negatively affects morphological growth and fruit development in melon ( L.). Chilling stress at the seedling stage causes seedling injury and poor stand establishment, prolonging vegetative growth and delaying fruit harvest.

: a fluorescent hypochlorous acid probe for live-cell and imaging and quantitative application in flow cytometry and a 96-well microplate assay.

Ultra-selective and ultra-sensitive probes for hypochlorous acid (HOCl), one of the most poorly understood reactive oxygen species (ROS), are urgently needed to unravel the HOCl functions in important biological processes such as development and innate immunity. Based on a selective oxidative -dearylation reaction of 2,6-dichlorophenol toward HOCl over other reactive oxygen species, we have developed a novel fluorescent probe for HOCl detection with ultra-selectivity, ultra-sensitivity and a rapid turn-on response. The functional robustness of for endogenous HOCl detection and imaging has been thoroughly scrutinized in multiple types of phagocytes and imaging of live intact zebrafish embryos.

Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo.

Superoxide anion radical (O2(•-)) is undoubtedly the most important primary reactive oxygen species (ROS) found in cells, whose formation and fate are intertwined with diverse physiological and pathological processes. Here we report a highly sensitive and selective O2(•-) detecting strategy involving O2(•-) cleavage of an aryl trifluoromethanesulfonate group to yield a free phenol. We have synthesized three new O2(•-) fluorescent probes (HKSOX-1, HKSOX-1r for cellular retention, and HKSOX-1m for mitochondria-targeting) which exhibit excellent selectivity and sensitivity toward O2(•-) over a broad range of pH, strong oxidants, and abundant reductants found in cells.

Association of leptin gene -2548 G/A polymorphism with obesity: a meta-analysis.

Background: A common single-nucleotide polymorphism identified in the 5'-untranslated region of the leptin gene (LEP -2548 G/A polymorphism) may be associated with obesity, but the existing research findings are inconsistent, so we conducted this meta-analysis.

Methods: Medline, Embase and ISI Web of Science databases were searched to identify relevant studies. Meta-analysis of the total and subgroup populations was conducted using allelic, additive, dominant and recessive models, and odds ratios and their 95% confidence intervals were calculated in a fixed-effect model if no heterogeneity (evaluated as I(2) statistic) existed.

Serum level of TSGF, CA242 and CA19-9 in pancreatic cancer.

Aim: To establish a method to detect the expression of the tumor specific growth factor TSGF, CA242 and CA19-9 in serum and evaluate their value in diagnosis of pancreatic cancer.

Methods: ELISA and Biochemical colorimetric assay were used to detect the serum content of TSGF, CA242 and CA19-9 in 200 normal cases, 52 pancreatitis patients and 96 pancreatic cancer patients.

Results: The positive likelihood ratios of TSGF, CA242 and CA19-9 were 5.