Effects of the copper intrauterine device on the expression of cyclooxygenase-1 and -2 in the endometrium.

Objective: To examine the expression levels of cyclooxygenase (COX)-1 and COX-2 in the endometrium before and after insertion of the copper intrauterine device (Cu-IUD).

Methods: Ten patients were investigated. Two endometrial biopsies were taken from the uterus of each patient.

[Effects of intrauterine contraceptive device on expression of vascular endothelial growth factor, kinase insert domain-containing receptor and microvessel density in endometrium].

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and its receptor, kinase insert domain-containing receptor(KDR) and microvessel density (MVD) in endometrium from women wearing fixed copper-intrauterine contraceptive device (IUD, FCu-IUD) or fixed indomethacin-releasing copper-IUD (FICu-IUD).

Methods: Twenty healthy women were divided into two study groups: 10 cases wearing the FCu-IUD (FCu-IUD group), 10 cases wearing the FICu-IUD (FICu-IUD group). Immunohistochemical technique was used to determine the expression of VEGF and KDR in endometrium, and the microvessel density (MVD) was counted.