Publications by authors named "Lu-Man Liu"

Previous research has revealed that platelets promote tumor metastasis by binding to circulating tumor cells (CTCs). However, the role of platelets in epithelial-mesenchymal transition (EMT) of cancer cells at the primary tumor site, the crucial initial step of tumor metastasis, remains to be elucidated. Here, we found that platelet releasate enhanced EMT and motility of hepatocellular carcinoma (HCC) cells via AMPK/mTOR-induced autophagy.

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Article Synopsis
  • Metastasis is the leading cause of cancer deaths, particularly in hepatocellular carcinoma (HCC), and is linked to high blood platelet counts and tumor expression of ADAM10, which indicate poor patient prognosis.
  • Research showed that platelets increase ADAM10 expression in tumor cells through the TLR4/NF-κB signaling pathway, leading to the shedding of CX3CL1 and promoting cancer cell migration and invasion.
  • The study highlights the potential of targeting the TLR4/ADAM10/CX3CL1 axis as a strategy to inhibit platelet-driven metastasis in HCC, supported by findings from both in vitro and in vivo mouse models.
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