Publications by authors named "Lu-Lu Yang"

Herein, we report a DMAP-catalyzed [4 + 2] annulation reaction of hex-5-en-2-ynoates with electron-poor alkenes , which affords exocyclic olefinic cyclohexenes in good yields and excellent regio-, diastereo-, and / selectivities. Distinguished from previous allenoate- or alkynoate-based substrates, hex-5-en-2-ynoates use the β- and ε-carbons for the bond formation, presenting new and regiodivergent C synthons for Lewis base-catalyzed annulations.

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  • YY1 is a key player in various liver diseases and its role in drug-induced liver injury (DILI) has been largely overlooked by researchers.
  • The study conducted thorough investigations involving multiple toxic compounds associated with YY1, revealing that many of these compounds are hepatotoxic, including well-known drugs.
  • Findings suggest that YY1 significantly contributes to DILI mechanisms, particularly through cholestasis, where it is up-regulated by hepatotoxic agents and negatively influences critical liver functions, demonstrating its potential as a focal point for understanding and addressing drug-induced liver injuries.
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  • The study aims to create a nomogram for early prediction of severe mycoplasma pneumoniae pneumonia (SMPP) in both pediatric and adult patients by analyzing 550 cases, classified into severe and non-severe groups.
  • Various models were developed using clinical data, imaging, and radiomics features, assessed through different statistical methods, including logistic regression and AUC metrics.
  • The integrated model showed strong predictive ability, particularly in testing cohorts, with a notable improvement when combining clinical and imaging features, demonstrating its effectiveness for identifying SMPP.
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Habitual daytime napping is a common behavioral and lifestyle practice in particular countries and is often considered part of a normal daily routine. However, recent evidence suggests that the health effects of habitual daytime napping are controversial. We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to March 9, 2024, to synthesize cohort studies of napping and health outcome risk.

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Herein, we report a catalyst-free reaction of cyclobutanone oximes with chlorophosphines (RPCl), which forms a fragile C═N-O-PR species that undergoes N-O homolysis, fragmentation, and radical-radical coupling, leading to the formation of cyano-containing phosphine oxides in good yields. The reaction features an activation of cyclobutanone oximes for radical generation, in which RPCl plays a dual role as both an activator and a reactant.

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Pathological cardiac hypertrophy (CH) is driven by maladaptive changes in myocardial cells in response to pressure overload or other stimuli. CH has been identified as a significant risk factor for the development of various cardiovascular diseases, ultimately resulting in heart failure. Melanoma differentiation-associated protein 5 (MDA5), encoded by interferon-induced with helicase C domain 1 (IFIH1), is a cytoplasmic sensor that primarily functions as a detector of double-stranded ribonucleic acid (dsRNA) viruses in innate immune responses; however, its role in CH pathogenesis remains unclear.

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Authentication and adulteration detection of closely related herbal medicines is a thorny issue in the quality control and market standardization of traditional Chinese medicine. Taking Fritillariae Bulbus (FB) as a case study, we herein proposed a three-step strategy that integrates mass spectrometry-based metabolomics and multivariate statistical analysis to identify specific markers, thereby accurately identifying FBs and determining the adulteration level. First, an ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based untargeted metabolomics method was employed to profile steroid alkaloids in five sorts of FB and screen potential differential markers.

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The saponin-enriched extract from Celosiae Semen is a promising resource owing to its lipid-lowering activity. However, triterpenoid saponins are difficult to extract owing to their high molecular weight and strong water solubility. The aim of this paper was to explore an eco-friendly and effective technology of extraction and enrichment of total triterpenoid saponins to obtain high lipid-lowering fractions.

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Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women. Unfortunately, effective targets are lacking, leading to a grim prognosis. Research highlights the crucial role of overexpression in this form of cancer.

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Background: Colon adenocarcinoma (COAD) is a major cause of cancer mortality worldwide. The occurrence and development of colon cancer is regulated by complex mechanisms that require further exploration. Recently, long non-coding RNAs (lncRNAs) were found to be related to the mortality of colon cancer patients through their participation in competing endogenous RNA (ceRNA) networks.

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Kawasaki disease, or mucocutaneous lymph node syndrome, is an acute systemic vasculitis involving small and medium-sized vessels. It can be complicated by varying degrees of cardiac damage, especially coronary artery disease. The disease mainly occurs in children aged < 5 years, with rarer cases in older children and adults.

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A visible-light-driven desaturative β-alkoxyoxalyation of N-aryl cyclic amines with difluoromethyl bromides and HO has been reported. This tandem reaction is triggered by homolysis of the C-Br bond to produce the difuoroalkyl radical, which undergoes the subsequent defluorinated β-alkoxyoxalylation cascades to afford a wide range of β-ketoester/ketoamides substituted enamines. The prominent feature of this reaction contains photocatalyst-free, transition-metal free, and mild conditions.

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A phosphine-catalyzed ring-opening addition reaction of cyclopropenones with a variety of nucleophiles (NuH), including oxygen-, nitrogen-, sulfur-, and carbon-based ones, has been investigated, which produces potentially useful α,β-unsaturated carbonyl derivatives in high yields (up to 99%), high regioselectivity, and exclusive -selectivity. The reaction proceeds in high efficiency under very mild conditions using only 1 mol % PPh as the catalyst at room temperature. The method is also amenable for the synthesis of deuterated alkenes when deuterated nucleophiles (NuD) are employed.

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Background: The occurrence and development of developmental dysplasia of the hip (DDH) are related to a variety of factors, which have been reported in the literature, but the literature does not mention factors related to the severity of DDH. The purpose of this study is to analyze the related factors of the occurrence and severity of DDH in combination with the Graf ultrasonic diagnostic classification.

Methods: This study was a monocentric retrospective study describing the factors associated with DDH in a large hospital of northwest China.

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  • Olfaction plays a crucial role in aphid behaviors, including host location and mating, with antennal primary rhinaria being essential for detecting chemical signals.
  • A study of three aphid subfamilies examined the morphology and distribution of antennal sensilla, identifying three types: placoid, coeloconic, and trichoid, with distinct patterns among species.
  • Neuronal responses to various plant volatiles showed that different species had unique profiles, with some antennal sensilla, particularly in LP5 and LP6, exhibiting strong excitatory responses to specific terpenes like (±)-citronellal and (-)-linalool.
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Background: TBL1XR1, also known as IRA1 or TBLR1, encodes a protein that is localized in the nucleus and is expressed in most tissues. TBL1XR1 binds to histones H2B and H4 in vitro and functions in nuclear receptor-mediated transcription. TBL1XR1 is also involved in the regulation of the Wnt-β-catenin signaling pathway.

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Background: Congenital nephrogenic diabetes insipidus (CNDI) is a rare hereditary disorder. It is associated with mutations in the arginine vasopressin receptor 2 (AVPR2) gene and aquaporin 2 (AQP2) gene, and approximately 270 different mutation sites have been reported for AVPR2. Therefore, new mutations and new manifestations are crucial to complement the clinical deficiencies in the diagnosis of this disease.

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Background Restenosis is one of the main bottlenecks in restricting the further development of cardiovascular interventional therapy. New signaling molecules involved in the progress have continuously been discovered; however, the specific molecular mechanisms remain unclear. MTMR14 (myotubularin-related protein 14) is a novel phosphoinositide phosphatase that has a variety of biological functions and is involved in diverse biological processes.

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Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase which is expressed in a variety of human tissues. RNF5 is involved in the regulation of endoplasmic reticulum stress, inflammation, and innate immunity and plays an important role in the occurrence and development of various tumors. However, the role of RNF5 in cardiac hypertrophy has not been reported.

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  • - The study evaluates the effectiveness of combining iodine-125 seed insertion (ISI) with trans-arterial infusion (TAI) in treating advanced non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) through a meta-analysis of relevant research.
  • - Results showed that patients receiving the combined treatment had significantly better outcomes in terms of complete response rates, treatment success rates, and overall survival compared to those who only received TAI.
  • - The findings suggest that while ISI can improve the results of TAI in advanced lung cancer patients, it does not increase the risk of severe side effects.
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Epimedii folium (EF) is an effective herbal medicine in osteoporosis treatment, but the clinical utilization of EF has been limited due to potential hepatotoxicity. The previous studies identified that baohuoside I (BI), the main active component of EF, was relevant to EF-induced liver injury. However, the mechanisms of BI causing direct injury to hepatocytes remain unclear.

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Phytase belongs to orthophosphate monoester hydrolase, which can catalyze the gradual hydrolysis of phytic acid to inositol phosphate. It can be added to animal feed to reduce the anti-nutritional factor of phytic acid in feed. The thermostability and specific activity of phytases are two key factors determining their potential applications.

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Introduction: Metal stenting can be used as a primary treatment option for alleviating malignant hilar biliary obstruction (MHBO) symptoms. Although many studies have focused on the topic of unilateral or bilateral stenting for MHBO, there is a clear need for a study comparing these two stenting types in patients with a single type of cancer.

Aim: This meta-analysis was conducted to evaluate the relative clinical efficacy of unilateral and bilateral metal stent insertion for hilar cholangiocarcinoma (HCCA).

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Background And Aims: NAFLD is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation, and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved.

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Objective: To investigate the expression of WTAP gene in acute myeloid leukemia (AML) and its clinical significance.

Methods: 74 acute myeloid leukemia patients with non-M3 type and 19 normal donors were selected, and real-time quantitative polymerase chain reaction was used to detect the mRNA expression level of WTAP gene in their bone marrow cells. The relationship between the mRNA expression level of WTAP gene and the clinical characteristics was analyzed.

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