Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition.

Purpose: Jatrorrhizine (JAT) is a natural protoberberine alkaloid, possesses detoxification, bactericidal and hypoglycemic activities. However, its anti-cancer mechanism is not clear. This study aimed to investigate the mechanism of JAT through which inhibits colorectal cancer in HCT-116 and HT-29 cells.

conidia possess antiproliferative and inducing apoptosis properties in gynaecological carcinoma cells.

is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells.