Publications by authors named "Lu-Ling He"
Article Synopsis
- * After treatment, measurements of serum blood urea nitrogen (BUN), creatinine (Cre), and urinary protein levels indicated significant renal injury in the model group, along with increased inflammatory factors linked to specific pathways (NLRP3 and TLR4/NF-κB).
- * Administration of anemoside B4 resulted in decreased levels of BUN, Cre, and urinary protein in certain dosage groups, demonstrating its potential to alleviate renal tubular injury and reduce inflammation.
Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity. However, the regulation of proteomic profiles in neurons suffering CORT stress is remaining elusive. Thus, the proteomic profiles of mouse neuronal C17.
View Article and Find Full Text PDFAnemoside B4 (B4) isolated from has anti-inflammatory activities in the colon and antitumor effects. However, its role in the prevention and treatment of kidney injury has not been reported. Here, we reported the effects of B4 on chronic kidney injury (CKI) and studied its related mechanism based on an adenine-induced kidney injury model in rats.
View Article and Find Full Text PDF[Study on acute kidney injury model induced by renal ischemia-reperfusion in rats].
Zhongguo Zhong Yao Za Zhi
March 2019
Article Synopsis
- This study focused on evaluating acute kidney injury (AKI) in male SD rats caused by renal arteriovenous ligation to enhance drug research methodologies.
- The procedure involved 40 minutes of ligation followed by 24 hours of reperfusion, revealing significant increases in serum creatinine (Crea) and blood urea nitrogen (BUN) levels, particularly with mixed renal artery and vein ligation.
- Additionally, the study found considerable pathological changes in kidney tissues, alongside notable increases in mRNA expression of inflammatory markers, indicating a pronounced response linked to the severity of kidney injury.
Article Synopsis
- - The study investigates how genetic variations in the oestrogen receptor α (ER-α) and osteocalcin (BGP) affect fasting plasma glucose (FPG) levels, which are important for metabolic health and show significant heritability.
- - Researchers analyzed 328 pre-menopausal Chinese women and found a notable link between ER-α PvuII genotypes and FPG levels, along with a significant interaction between this polymorphism and BGP HindIII, although BGP HindIII alone did not show a direct connection to FPG.
- - The findings suggest that specific genetic variants in the ER-α gene and their interaction with BGP may play a role in regulating fasting plasma glucose in this population group, highlighting