Publications by authors named "Lu-Hui Yang"
Cutaneous drug reactions (CDRs) are common drug-induced allergic reactions that cause severe consequences in HIV/AIDS patients. The CCL17/CCR4 axis is involved in the immune mechanism of allergic diseases, but its role in the CDRs has not been determined. Here, we aimed to determine the role of the CCL17/CCR4 axis and the underlying mechanism involved in CDRs.
View Article and Find Full Text PDFLeprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their mutual exclusion have not been extensively investigated. This study aimed to reveal the underlying mechanism responsible for the mutual exclusion between psoriasis and leprosy. We obtained leprosy and psoriasis data from ArrayExpress and GEO database.
View Article and Find Full Text PDFArticle Synopsis
- Macrophage-derived inflammatory cytokines play a crucial role in fighting T. marneffei infections in HIV/AIDS patients, but too many cytokines can lead to worse outcomes for the disease.
- The study found that T. marneffei triggers pyroptosis in macrophages via the NLRP3/caspase-1 pathway, and that the drug thalidomide enhances this process in infected macrophages.
- While thalidomide helped reduce inflammation in T. marneffei-infected mice, combining it with amphotericin B did not improve overall survival compared to using amphotericin B alone.
Talaromycosis is a fatal mycosis caused by the thermally dimorphic fungus Talaromyces marneffei (T. marneffei). The pathogenic mechanisms of talaromycosis are still poorly understood.
View Article and Find Full Text PDFClinical characteristics of patients with human immunodeficiency virus and immune-mediated photodermatoses: A retrospective study of 39 patients.
Photodermatol Photoimmunol Photomed
March 2023
Background: HIV/AIDS patients are susceptible to various infectious and inflammatory dermatoses. No systemic work has been done on HIV/AIDS patients with immune-mediated photodermatoses in China. Here, we aim to determine the clinical features of immune-mediated photodermatoses in HIV/AIDS patients.
View Article and Find Full Text PDFBackground: Psoriasis is a common inflammatory skin disease that has a great impact on patients' physical and mental health. However, the causes and underlying molecular mechanisms of psoriasis are still largely unknown.
Methods: The expression profiles of genes from psoriatic lesion samples and skin samples from healthy controls were integrated the sva software package, and differentially expressed genes (DEGs) between psoriasis and healthy skin were screened by the limma package.