A Genome-Wide Characterization of Receptor-like Cytoplasmic Kinase IV Subfamily Members in Identifies the Potential Role of in Plant Osmotic Stress Responses.

The IV subfamily of receptor-like cytoplasmic kinase (RLCK-IV), known as calcium-binding receptor-like cytoplasmic kinases (CRCKs), plays a vital role in plant signal transduction, particularly in coordinating growth and responses to abiotic stresses. However, our comprehension of CRCK genes in , a species characterized as fast-growing and pest-resistant but with drought intolerance, is limited. Here, we identify 6 members of the CRCK subfamily on a genome-wide scale in , denoted as -.

Analysis of Volatile Compounds' Changes in Rice Grain at Different Ripening Stages via HS-SPME-GC-MS.

Aroma is a crucial determinant of rice taste quality, with volatile organic compounds (VOCs) playing a key role in defining this characteristic. However, limited research has explored the dynamic changes in these aromatic substances during the ripening stages of rice grains. In this study, we analyzed VOCs in rice grains across four ripening stages post-flowering using headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS).

Quantitative Classification and Prediction of Starkrimson Pear Maturity by Near-Infrared Spectroscopy.

Scientific evaluation of pear maturity is important for commercial reasons. Near-infrared spectroscopy is a non-destructive method that could be used for rapid assessment of pear maturity. The aim of this study was to develop a reasonable and effective method for the assessment of Starkrimson pear maturity using near-infrared technology.

Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway.

Diabetic kidney disease (DKD) is a severe diabetic microvascular complication featured by chronic low-grade inflammation. Roux-en-Y gastric bypass (RYGB) surgery has gained importance as a safe and effective surgery to treat DKD. Bile acids are significantly changed after RYGB, which brings a series of metabolic benefits, but the relationship with the improvement of DKD is unclear.

Non-metallic surface-modified X-Cu (X = F, Cl, Br) metal catalysts for all-pH hydrogen evolution reaction with high performance.

Producing hydrogen through water electrolysis represents a clean and sustainable solution that is crucial in addressing the energy crisis. Nonetheless, the slow process of water electrolysis leads to large different kinetics for hydrogen evolution reaction (HER) under different pH solutions. Here, we designed surface modified metallic X-Cu catalysts (X = F, Cl, Br) with different non-metallic elements on nickel foam (NF) using an electrochemical deposition method, which realizes high performance for all-pH range.

Size-Coded Hydrogel Microbeads for Extraction-Free Serum Multi-miRNAs Quantifications with Machine-Learning-Aided Lung Cancer Subtypes Classification.

Classifying lung cancer subtypes, which are characterized by multi-microRNAs (miRNAs) upregulation, is important for therapy and prognosis evaluation. Liquid biopsy is a promising approach, but the pretreatment of RNA extraction is labor-intensive and impairs accuracy. Here we develop size-coded hydrogel microbeads for extraction-free quantification of miR-21, miR-205, and miR-375 directly from serum.

Utilizing machine learning approaches to investigate the relationship between cystatin C and serious complications in esophageal cancer patients after esophagectomy.

Background: The purpose of this study is to investigate the relationship between preoperative cystatin C levels and the risk of serious postoperative complications in esophageal cancer (EC) patients, utilizing advanced machine learning (ML) methodologies.

Methods: We conducted an observational cohort study, involving 524 EC patients from December 2014 to July 2022. ML models, including logistic regression (LR) and multilayer perceptron (MLP), were applied to investigate the relationship between cystatin C and the serious postoperative complications.

Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development.

Although genome-wide association studies have identified dozens of loci associated with colorectal cancer (CRC) susceptibility, the causal genes or risk variants within these loci and their biological functions often remain elusive. Recently, the genomic locus 12p13.32, with the tag single-nucleotide polymorphism rs10774214, was identified as a crucial CRC risk locus in Asian populations.

Hepatocyte HIF-2α aggravates NAFLD by inducing ferroptosis through increasing extracellular iron.

Recent research has illuminated the pivotal role of the hypoxia-inducible factor-2α (HIF-2α)/peroxisome proliferator-activated receptor alpha (PPARα) pathway in the progression of nonalcoholic fatty liver disease (NAFLD). Meanwhile, it has been reported that HIF-2α is involved in iron regulation, and that aberrant iron distribution leads to liver lipogenesis. Therefore, we hypothesize that HIF-2α exacerbates fatty liver by affecting iron distribution.

Sex Differences in Ependymoma Methylation by Methylation-Defined Subgroup.

Ependymoma is the second most common malignant paediatric brain tumour composed of nine methylation-defined, clinically relevant subgroups. It is unclear if there are sex differences in methylation profiles within these subgroups which could guide future treatment options. We obtained available methylation data from the National Center for Biotechnology Information Gene Expression Omnibus (GEO).

Emphysematous pancreatitis: Diagnosis, treatment, and prognosis.

Background: Emphysematous pancreatitis (EP) is a rare, severe form of acute necrotizing pancreatitis characterized by gas in pancreatic or peripancreatic tissue, with a high mortality rate.

Aim: To assess the diagnosis, treatment, and outcomes of EP through a series of case studies.

Methods: This case series was conducted in intensive care units at the Second Affiliated Hospital of Anhui Medical University.

Clinical features and survival analysis of non-hypertensive aortic dissection patients post-thoracic endovascular aortic repair: a 10-year retrospective study.

Background: The clinical characteristics and predictors for aortic adverse events (AAEs) after thoracic endovascular aortic repair (TEVAR) of non-hypertensive aortic dissection (AD) patients remain unclear. This study sought to clarify the clinical features of non-hypertensive AD and its incidence of AAEs after TEVAR.

Methods: Clinical data were collected from the electronic medical records, imaging databases and follow-up.

Thyroid FT4-to-TSH ratio in the first trimester is associated with gestational diabetes mellitus in women carrying male fetus: a prospective bi-center cohort study.

Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which increases the risk of other pregnant complications and adverse perinatal outcomes. Thyroid dysfunction is closely with the risk of diabetes mellitus. However, the relationship between euthyroid function in early pregnancy and GDM is still controversial.

Identification of Candidate Hub Genes and Drug Targets for Cholangiocarcinoma via Juhua (Chrysanthemum Morifolium) Bioactivity and Molecular Docking: A Bioinformatics Approach.

Background: Cholangiocarcinoma (CHOL) is a malignancy with poor clinical outcomes and limited treatment options. While extensive research has investigated genetic and signaling pathways in CHOL, the molecular mechanisms underlying disease pathogenesis remain incompletely understood. A key hurdle has been the lack of a systematic, multi-omic approach to illuminate causal relationships between genetic variants and CHOL risk.

The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.

Studies on transcription regulation in platyhelminth development are scarce, especially for parasitic flatworms. Here, we employed single-cell transcriptomics to identify genes involved in reproductive development in the trematode model Schistosoma mansoni. This parasite causes schistosomiasis, a major neglected infectious disease affecting >240 million people worldwide.

The value of dual-energy computed tomography angiography-based virtual monoenergetic imaging for evaluations after cerebral aneurysm clipping.

Purpose: This study aimed to research the optimal energy range of dual-energy computed tomography angiography (DECTA)-based virtual monoenergetic imaging (VMI) for evaluations after cerebral aneurysm clipping.

Methods: Sixty patients who underwent DECTA after cerebral aneurysm clipping were analyzed retrospectively. Conventional computed tomography angiography (CTA) was compared with VMIs at 60, 70, 80, 90, and 100 keV.

Mechanisms underlying the spontaneous reorganization of depression network after stroke.

Exploring the causal relationship between focal brain lesions and post-stroke depression (PSD) can provide therapeutic insights. However, a gap exists between causal and therapeutic information. Exploring post-stroke brain repair processes post-stroke could bridge this gap.

Electrically driven phosphorus dissolution from iron-nickel phosphate surfaces exposing highly active sites for oxygen evolution reaction.

The enhancement of catalytic activity can be achieved by removing non-active components from the surface of catalyst materials, thereby increasing the accessibility of active sites. In this study, an electrically driven method is described for the removal of non-active phosphorus (P) to optimize the surface composition of iron-nickel phosphide (denoted as P-O-NFF), resulting in the exposure of more active Fe-Ni sites for oxygen evolution reaction (OER). The optimized P-O-NFF electrode exhibits exceptional OER catalytic activity, with an overpotential of 217 mV at 10 mA cm.

Clinical efficacy analysis of the Chinese medicine Paiteling applied to human papillomavirus infection: A retrospective study.

Aim: To investigate the clinical efficacy of population-based treatment of human papillomavirus (HPV) infections with Paiteling.

Methods: Between 1 June 2024 and 31 August 2024, 575 HPV-infected patients attending The First People's Hospital of Jingzhou gynecology outpatient clinic from October 2020 to December 2023 were retrospectively collected, all of whom were analyzed for HPV subtype infection and the presence or absence of cytomorphological abnormality using HPV-DNA testing and TCT; they were divided into 319 cases in the Paiteling group and 256 cases in the Interferon group, and the patients of both groups were subjected to TCT 1 month after the end of the administration of the medication and HPV review.

Results: 1.

Supraventricular ectopic activity predicts postoperative atrial fibrillation, new onset atrial fibrillation and worse survival in obstructive hypertrophic cardiomyopathy.

Background: Supraventricular ectopic activity (SVEA) is a marker of foci that may initiate atrial fibrillation (AF) and is associated with worse survival. The types and frequencies of SVEA for predicting postoperative AF (POAF), new-onset AF, and clinical outcomes in obstructive hypertrophic cardiomyopathy(oHCM) remain unknown.

Method: Our study consecutively recruited 961 patients with oHCM.

Dynamic laser protection window based on a topological state photonic crystal of a nonlinear LiNbO interface.

The accelerated advancement of high-energy laser technology has resulted in an increased necessity for multifunctional laser protection. Herein, we present an investigation into a static visible and dynamic 1064 nm laser protection window. Through studying the photonic crystal energy band structure and topological interface state properties, both 66.