Publications by authors named "Lu Z Meng"
Background: The rapid adoption of image-guidance in prostate intensity-modulated radiotherapy (IMRT) results in longer treatment times, which may result in larger intrafraction motion, thereby negating the advantage of image-guidance. This study aims to qualify and quantify the contribution of image-guidance to the temporal dependence of intrafraction motion during prostate IMRT.
Methods: One-hundred and forty-three patients who underwent conventional IMRT (n=67) or intensity-modulated arc therapy (IMAT/RapidArc, n=76) for localized prostate cancer were evaluated.
To compare 2 beam arrangements, sectored (beam entry over ipsilateral hemithorax) vs circumferential (beam entry over both ipsilateral and contralateral lungs), for static-gantry intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques with respect to target and organs-at-risk (OAR) dose-volume metrics, as well as treatment delivery efficiency. Data from 60 consecutive patients treated using stereotactic body radiation therapy (SBRT) for primary non-small-cell lung cancer (NSCLC) formed the basis of this study. Four treatment plans were generated per data set: IMRT/VMAT plans using sectored (-s) and circumferential (-c) configurations.
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- - The study aimed to analyze the hepatitis B virus (HBV) reverse transcriptase (RT) in treatment-naive patients in China, focusing on mutation profiles and constructing a database for future research.
- - Serum samples from 328 chronic HBV patients revealed variations in the RT region, with different mutation rates and genotypes, showing a predominance of thymidine and the presence of antiviral resistance mutations like M204V/I.
- - Findings indicated that antiviral-resistant strains exist in patients without treatment, and viral replication may be linked to the variability of the virus, suggesting a need for further exploration in this area.