Publications by authors named "Lu X"

Article Synopsis
  • The study investigates how geographic location affects the characteristics and treatment processes of patients with acute ischemic stroke (AIS) in southeastern China, comparing coastal, island, and inland areas.
  • It analyzes data from over 8,000 AIS patients, finding that maritime hospitals have better access to therapies and shorter hospital processing times compared to inland hospitals.
  • The findings highlight notable differences in stroke treatment across regions, suggesting the importance of tailored public health strategies to enhance stroke care and outcomes.
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  • A new type of T cell, called peripheral helper T (Tph) cells, has been linked to autoimmune diseases and has a unique role in regulating kidney-related conditions.
  • Tph cells secrete important immune molecules like interleukin-21 (IL-21) and interferon (IFN) and can gather in large groups within inflamed tissues.
  • Compared to T follicular helper (Tfh) cells, Tph cells express higher levels of specific proteins (like PD-1 and MHC-II) and have distinct characteristics that enhance B cell responses in inflamed areas of the body.
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  • - The study investigates how brittle rock behaves under stress, particularly in railway tunnels, using uniaxial compression tests and acoustic emission monitoring at various loading rates.
  • - Results indicate that higher loading rates enhance rock strength and extend elastic deformation while changing fracture patterns from shear to tensile types.
  • - Acoustic emission activity increases significantly with higher loading rates, showing that tensile fractures exhibit greater intensity than shear fractures, and early warning indicators for potential rock failure are identified.
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The large voltage loss () mainly stems from the mismatch between the perovskite film and electron transport layer in CsPbIBr-based all-inorganic perovskite solar cells (I-PSCs), which restricts the power conversion efficiency (PCE) of devices. To address this issue, potassium benzoate (BAP) is first introduced as a bifunctional passivation material to regulate the TiO/CsPbIBr interface, reduce the , and improve the photovoltaic performance of CsPbIBr-based I-PSCs. Eventually, the champion PCE of CsPbIBr-based I-PSCs without a hole transport layer modified by BAP (Target-PSCs) improves to 14.

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Cerebral microbleeds (CMBs) lead to cognitive decline, linked to the axonal structure composed of phospholipid bilayers. Current methods are difficult to obtain in situ changes of biochemical component concentration during CMB. In this study, by Raman spectrum and two-photon imaging, we achieve in situ changes in the information of biochemical components concentration during CMB.

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  • * U937 cells were modified using RNA interference and overexpression techniques to examine the effects of Tollip on cell behavior and TB infection in a lab setting.
  • * Results indicate that Tollip can negatively regulate factors in the TLR4 pathway, suggesting its potential as a biomarker for early TB diagnosis.
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The capacity and cycling stability of β-Ni(OH)-based cathodes in aqueous alkaline Ni-Zn batteries are still unsatisfactory due to their undesirable OH adsorption/desorption dynamics during the electrochemical redox process. To settle this issue, we introduce a new atomic-level strategy to finely modulate the OH adsorption/desorption of β-Ni(OH) through tailoring the 3d-orbital occupancy of Ni center by Co/Cu co-doping (denoted as Co-Cu-Ni(OH)). Both experimental outcomes and density functional theory calculations validate that the co-doping of Co and Cu endows the Ni species in Co-Cu-Ni(OH) with appropriate proportion of the unoccupied 3d-orbital, leading to optimized adsorption/desorption strength of OH.

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Objectives: Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL.

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  • Coronaviruses encode 16 nonstructural proteins that form replication-transcription complexes crucial for viral RNA synthesis, with nsp14 acting as a key exoribonuclease for proofreading and replication fidelity.
  • Mutations introduced at the nsp14-nsp10 interface in murine hepatitis virus led to varying levels of impairments in replication and exonuclease activity, highlighting the importance of this interaction.
  • The study's findings emphasize the potential of targeting the nsp14-10 interface for developing viral inhibitors and improving understanding of coronavirus pathogenesis.
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  • β-catenin and STAT3 contribute to colorectal cancer (CRC) progression and immune evasion, with their co-overexpression linked to poor patient outcomes.
  • Traditional small molecule inhibitors struggle to effectively target both proteins due to their mutual activation.
  • A new strategy using nanoengineered peptide PROTACs (NP-PROTACs) has been developed, successfully degrading both β-catenin and STAT3, resulting in improved antitumor effects and enhanced immune responses in CRC treatment.
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In this study, the influence of solid-state fermentation (SSF) using probiotic on the change of volatile organic compounds (VOCs) and α-glucosidase inhibition activity of soybeans was investigated. A total of 46 VOCs were characterized via headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), the majority of which were aldehydes (17), alcohols (10), and ketones (7). SSF by .

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Wheat () is one of the most important staple crops worldwide. To ensure its global supply, the timing and duration of its growth cycle needs to be closely monitored in the field so that necessary crop management activities can be arranged in a timely manner. Also, breeders and plant researchers need to evaluate growth stages (GSs) for tens of thousands of genotypes at the plot level, at different sites and across multiple seasons.

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  • Programmed cell death 1 (PD-1) and its ligand (PD-L1) are crucial in studying immune checkpoints in urinary tract tumors, with increasing use of their inhibitors in treatment.* -
  • A bibliometric analysis of 1,711 articles published from 1999 to 2022 highlighted the US as the leading contributor, spearheaded by Harvard University and major author Choueiri TK.* -
  • Key topics in this research include "immunotherapy," "renal cell carcinoma," and "bladder cancer," with the most cited publication by Topalian SL in 2012, emphasizing the growing focus on PD-1/PD-L1 in kidney and bladder cancer treatments.*
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Hepatocellular cancer (HCC) remained a life-threatening carcinoma. Agents for HCC imaging and therapy were expected to possess different intratumoral retention time. To construct an agent with different intratumoral retention time when applied for tumor imaging or therapy remained great values.

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Background: Recently, deep learning has been increasingly applied in the field of dentistry. The aim of this study is to develop a model for the automatic segmentation, numbering, and state assessment of teeth on panoramic radiographs.

Methods: We created a dual-labeled dataset on panoramic radiographs for training, incorporating both numbering and state labels.

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Ancient murals embody profound historical, cultural, scientific, and artistic values, yet many are afflicted with challenges such as pigment shedding or missing parts. While deep learning-based completion techniques have yielded remarkable results in restoring natural images, their application to damaged murals has been unsatisfactory due to data shifts and limited modeling efficacy. This paper proposes a novel progressive reasoning network designed specifically for mural image completion, inspired by the mural painting process.

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  • Persistent macrophage activation and cytokine storms are key contributors to the severity and mortality associated with Secondary Hemophagocytic lymphohistiocytosis (sHLH), making it essential to understand what regulates macrophage activation.
  • * Plasma exosomal circular RNAs (circRNAs), while recognized as important biomarkers and potential therapies, have an unclear role in sHLH; this study identifies circMETTL3 as a significant factor elevated in sHLH patient plasma exosomes, which could assist in diagnosing the condition.
  • * The study also discovers that a peptide from circMETTL3, METTL3-156aa, promotes M1 macrophage polarization through enhanced macrophage glycolysis and creates a feedback loop involving lactate and S
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  • * The review categorizes potential biomarkers based on their measurement targets: within-individual perception, between-individual sensitivity, and discriminability for acute pain, along with assessment and prospective biomarkers for chronic pain.
  • * Various neuroimaging techniques like fMRI, sMRI, and EEG are utilized to explore these biomarkers, while the review also highlights the challenges faced in their development, emphasizing the need for optimal biomarkers to improve pain management and patient well-being.
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Aluminum (Al) toxicity is a significant limiting factor for crop production in acid soils. The functions and regulatory mechanisms of transcription factor STOP1 (Sensitive to Proton Rhizotoxicity 1) family genes in Al-tolerance have been widely studied in many plant species, except for soybean. Here, expression of GmSTOP1-3 was significantly enhanced by Al stress in soybean roots.

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  • Understanding chronic pain (CP) development is complex, especially its link to child maltreatment (CM), which affects over one-third of people and leads to lasting consequences.
  • The study uses a large dataset of 150,989 individuals to show that most types of CM increase CP risk and that those with CM histories are more likely to experience multiple CP conditions.
  • Findings highlight that over 60% of the CM-CP connection is explained by biopsychosocial factors, particularly psychological ones, suggesting the need for focused treatment and prevention strategies for chronic pain.
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The hydrolysis of cellulose generates inhibitors like acetate, suppressing fermentation performance. Here, 25SrRNA methyltransferase CgBMT5 from stress-tolerant yeast Candida glycerinogenes was used as an anti-stress gene element in Saccharomyces cerevisiae and Yarrowia lipolytica. Expression of CgBMT5 in S.

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The advancement of thin, lightweight, and high-power electronic devices has increasingly exacerbated issues related to electromagnetic interference and heat accumulation. To address these challenges, a spray-drying-sintering process is employed to assemble chain-like CoNi and flake boron nitride (BN) into hydrangea-like CoNi@BN heterostructure fillers. These fillers are then composited with polydimethylsiloxane (PDMS) to develop CoNi@BN/PDMS composites, which integrate low-frequency microwave absorption and thermal conductivity.

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Background: With the increasing prevalence of obesity, there is growing awareness of the impact of overweight and obesity on total hip arthroplasty (THA). Research exploring the accuracy of acetabular component orientation in THA between robotic-assisted and manual techniques across different BMI categories is insufficient.

Methods: This prospective study evaluated 221 patients who underwent THA with a Robotic Interactive Orthopaedic Arm system and 252 patients who underwent manual THA between March 2022 and January 2024.

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  • Diabetic nephropathy (DN) is a major contributor to end-stage renal disease, with unclear mechanisms hindering effective diagnosis and treatment.* -
  • The study used nanopore-based transcriptome sequencing on blood samples from patients with slow (DNSP) and rapid (DNRP) progression of DN, identifying thousands of novel transcripts and genes.* -
  • Key findings revealed that specific pathways related to oxidative stress, lipid metabolism, and cell death processes are differentially expressed in slow versus fast progressing DN, offering insights for future research.*
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Hutchinson-Gilfor progeria syndrome (HGPS) is caused by a mutation in Lamin A resulting in the production of a protein called progerin. The accumulation of progerin induces inflammation, cellular senescence and activation of the P53 pathway. In this study, through public dataset analysis, we identified Syntaxin Binding Protein 5 (STXBP5) as an influencing factor of progerin expression.

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