Plasmonic Nanostructures Grown from Reacting Droplet-In-Microwell Array on Flexible Films for Quantitative Surface-Enhanced Raman Spectroscopy in Plant Wearable In Situ Detection.

Plant wearable detection has garnered significant interest in advancing agricultural intelligence and promoting sustainable food production amidst the challenges of climate change. Accurately monitoring plant health and agrochemical residue levels necessitates qualities such as precision, affordability, simplicity, and noninvasiveness. Here, a novel attachable plasmonic film is introduced and designed for on-site detection of agrochemical residues utilizing surface-enhanced Raman spectroscopy (SERS).

Asphaltene-Derived Graphene Quantum Dots for Controllable Coatings on Glass, Fabrics, and Aerogels.

Graphene quantum dots (GQDs) derived from natural asphaltene byproducts can produce controlled hydrophobic or hydrophilic interfaces on glass, fabrics, and aerogels. A set of facile solvent extraction methods were used to isolate and chemically prepare materials with different surface functionalities from a commercially derived asphaltene precursor. The organic-soluble fraction was used to create hydrophobic and water-repellent surfaces on glass and cotton fabrics.

Fabrication and Characterization of π-π Stacking Peptide-Contained Double Network Hydrogels.

Since the physical properties are similar to native extracellular matrices, double network (DN) hydrogels have been studied extensively in the tissue engineering. However, the double chemical crosslinked DN hydrogel is limited by poor fatigue resistance. π-π stacking is a non-covalent bonding interaction, which is essential to maintain and self-assemble the three-dimensional structure of biological proteins and nucleic acids.

Explainable machine learning for long-term outcome prediction in two-center stroke patients after intravenous thrombolysis.

Objective: Neurological outcome prediction in patients with ischemic stroke is very critical in treatment strategy and post-stroke management. Machine learning techniques with high accuracy are increasingly being developed in the medical field. We studied the application of machine learning models to predict long-term neurological outcomes in patients with after intravenous thrombolysis.

Recent progress and applications of poly(beta amino esters)-based biomaterials.

Poly(beta-amino esters, PBAEs) are a promising class of cationic polymers synthesized from diacrylates and amines via Michael addition. Recently, PBAEs have been widely developed for drug delivery, immunotherapy, gene therapy, antibacterial, tissue engineering and other applications due to their convenient synthesis, good bio-compatibility and degradation properties. Herein, we mainly summarize the recent progress in the PBAEs synthesis and their applications.

Prognostic nomogram for the outcomes in acute stroke patients with intravenous thrombolysis.

Background And Purpose: The prediction of neurological outcomes in ischemic stroke patients is very useful in treatment choices, as well as in post-stroke management. This study is to develop a convenient nomogram for the bedside evaluation of stroke patients with intravenous thrombolysis.

Materials And Methods: We reviewed all enrolled stroke patients with intravenous thrombolysis retrospectively.

Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor.

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson's disease (PD), which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; however, the precise mechanism has yet to be determined. We demonstrated for the first time that CTSL was mostly released by exosomes derived from α-Syn-activated microglia, resulting in neuronal damage and death. The elevation of CTSL activity was blocked by GW4869, suggesting a critical role for exosomes in mediating CTSL release.

Clinical efficacy and safety of two concentrations of intravenous nicardipine hydrochloride for nicardipine-related phlebitis in patients with preeclampsia.

To evaluate the effect of two concentrations of intravenous administration of nicardipine hydrochloride on nicardipine-related phlebitis in patients with preeclampsia. A total of 100 preeclampsia patients were administered with nicardipine hydrochloride and divided into the low-concentration (LC) and high-concentration (HC) groups. The incidence and severity of phlebitis, time from treatment to onset of phlebitis, skin temperature, visual analogue scale (VAS) score, induration, and systemic adverse reactions were compared between two groups.

Effectiveness and Predictors of Poor Prognosis Following Intravenous Thrombolysis in Patients with Wake-Up Ischemic Stroke Guided by Rapid MRI.

Purpose: Our aim was to investigate the effectiveness and predictors of poor prognosis in WUIS patients who received alteplase thrombolysis under the guidance of diffusion-weighted imaging (DWI)-T2-weighted imaging (T2WI) mismatch.

Patients And Methods: We recruited patients within 4.5 h of acute ischemic stroke (AIS) and WUIS patients with uncertain onset times from two stroke centers.

"Desire Is Like a Dreadful Monster": Analysis of Extended Metaphors in L2 Argumentative Essays by Chinese Learners of English.

This article explores the use, function, and understanding of extended metaphors in L2 argumentative essays by Chinese learners of English. The analysis starts with the identification of linguistic metaphors and extended metaphors in 72 argumentative texts produced by 37 intermediate Chinese English majors. The function of extended metaphors is then analyzed by adopting the bottom-up approach of establishing systematic metaphors from those identified extended metaphors, to draw learners' communicative intentions in producing extended metaphors.

In-situ fabrication of metal oxide nanocaps based on biphasic reactions with surface nanodroplets.

Hypothesis: Surface-bound nanomaterials are widely used in clean energy techniques from solar-driven evaporation in desalination to hydrogen production by photocatalytic electrolysis. Reactive surface nanodroplets may potentially streamline the process of fabrication of a range of surface-bound nanomaterials invoking biphasic reactions at interfaces.

Experiments: In this work, we demonstrate the feasibility of reactive surface nanodroplets for in situ synthesis and anchoring of nanocaps of metal oxides with tailored porous structures.

Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of rat models.

Allowing for the correlation between intermittent hypoxia and impaired cognition, we intended to figure out whether and how dementia-relevant biomolecules (e.g. miR-125b and p38MAPK) might participate in weakening of intelligence in the context of intermittent hypoxia.