Characterization of microplastic distribution, sources and potential ecological risk assessment of domestic sewage from ships.

Shipboard domestic sewage, encompassing both black water and gray water, has the potential to transport significant quantities of environmentally harmful microplastics, a concern that has garnered increasing global attention. In this study, Fourier infrared (FTIR) detection was used to detect microplastics in marine domestic wastewater. The primary objective was to evaluate the abundance and characteristics of microplastics present in ship domestic sewage, investigate potential sources and influencing factors, and assess the ecological risks associated with ship sewage through analyses of microplastic abundance and hazard indices.

A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol.

Syringaresinol, a phytochemical constituent belonging to lignan, is formed from two sinapyl alcohol units linked via a β-β linkage, which can be found in a wide variety of cereals and medicinal plants. Medical researches revealed that Syringaresinol possesses a broad spectrum of biological activities, including anti-inflammatory, anti-oxidation, anticancer, antibacterial, antiviral, neuroprotection, and vasodilation effects. These pharmacological properties lay the foundation for its use in treating various diseases such as inflammatory diseases, neurodegenerative disorders, diabetes and its complication, skin disorders, cancer, cardiovascular, and cerebrovascular diseases.

Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A.

Background: Semaphorin7A (SEMA7A) has been found to regulate both nerve and vessel homeostasis, but its specific role in pan-cancer remains uncertain. This research seeks to delve into the function and clinical relevance of SEMA7A in pan-cancer.

Methods: Through an analysis of gene expression omnibus and the cancer genome atlas datasets, we investigated the impact of SEMA7A on prognosis and immune regulation across 33 types of tumors.

Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine.

Tumor necrosis factor receptor-associated factor 4 (TRAF4), an E3 ubiquitin ligase, is frequently overexpressed in tumors. Although its cytoplasmic role in tumor progression is well-documented, the precise mechanisms underlying its nuclear localization and functional contributions in tumor cells remain elusive. This study demonstrated a positive correlation between the expression of nuclear TRAF4 and both tumor grades and stemness signatures in human cancer tissues.

Precise manipulation of iron spin states in single-atom catalytic membranes for singlet oxygen selective production.

Heterogeneous single-atom catalysts are attracting substantial attention for selectively generating singlet oxygen (O). However, precise manipulation of atom coordination structures remains challenging. Here, the fine coordination structure of iron single-atom carbon-nitride catalysts (Fe-CNs) was manipulated by precisely tuning the heating rate with 1 °C min difference.

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies.

Objective: To emulate target trials comparing recurrence of nephrolithiasis among patients with pre-existing nephrolithiasis (overall and stratified by concomitant gout) initiating sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus an active comparator.

Design: Target trial emulation studies.

Setting: Canadian population database, January 2014 to June 2022.

CORO1C Regulates the Malignant Biological Behavior of Ovarian Cancer Cells and Modulates the mRNA Expression Profile through the PI3K/AKT Signaling Pathway.

Ovarian cancer (OC) is a frequently occurring gynecological tumor, and its global incidence has recently increased. Coronin-like actin-binding protein 1C (CORO1C) is known to activate the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) pathway and promote tumor progression. However, its role in OC remains unclear.

The Role of Camellia Shell Substrates in Modulating the Nutritional Characteristics of .

Camellia shells are the main by-product of camellia seed processing and are usually incinerated or disposed of as agricultural waste. In this study, camellia shells were employed in the cultivation process using five distinct formulae substituting for cottonseed shells. Our results show that as the substitution rate of camellia shells increased from 0% to 35%, the protein content in significantly increased from 34.

Spatial-temporal differences and convergence analysis of residential building carbon emission efficiency in China.

Data indicate that carbon dioxide emissions from residential buildings in China constitute 60% of the country's total, making carbon reduction efforts in residential construction crucial for achieving dual carbon goals. From the perspective of eight major economic regions, this paper selects energy consumption, per capita residential area, and residential population as input indicators, per capita disposable income as the output indicator, and carbon dioxide emissions as the undesired output indicator. It employs the super-efficiency model based on the directional distance (super-DDF) function and the Malmquist-Luenberger (ML) index to measure the static and dynamic carbon emission efficiencies of residential buildings (RBCEE) during their operational phase from 2010 to 2020.

Gambogic acid impairs the maintenance and therapeutic resistance of glioma stem cells by targeting B-cell-specific Moloney leukemia virus insert site 1.

Background: Glioblastoma (GBM) is the most common and lethal primary brain tumor with low effectiveness of available treatments. The tumor heterogeneity and therapeutic resistance are largely due to the presence of glioma stem cells (GSCs). Therefore, eliminating GSCs can overcome the progression, relapse, and resistance of GBM.

Construction of COFs@MoS-Pd Hierarchical Tubular Heterostructures for Enhanced Catalytic Performance.

Here, we report ternary COFs@MoS-Pd hybrids with an innovative self-sacrificial approach. MoO@Covalent organic frameworks (COFs) microcables were first prepared and then two-dimensional MoS nanosheets (NSs) were integrated onto the surface of COFs, as COFs@MoS, after treatment with hydrothermal reaction. The MoS NSs were used as an excellent support to introduce Pd nanoparticles (NPs) thanks to their reducing ability for the formation of the ternary COFs@MoS-Pd hybrids.

Promoting Electrocatalytic Reduction of CO and Nitrate to Urea on N-Doped Porous Hollow Carbon Spheres.

The electrocatalytic coreduction of CO and nitrate is a green method for urea synthesis, mitigating CO emission and nitrate contamination. However, its slow kinetics and high energy barrier result in a poor urea production performance. Herein, we reported N-doped porous hollow carbon spheres (N-PHCS) for promoting CO and nitrate conversion to urea via nanoconfinement and N-doping from both reaction kinetics and thermodynamics.

Sorafenib-mediated cleavage of p62 initiates cellular senescence as a mechanism to evade its anti-hepatocellular carcinoma efficacy.

Hepatocellular carcinoma (HCC) stands as one of the most aggressively advancing and lethal malignancies. Sorafenib is presently endorsed as a primary therapy for advanced liver cancer, but its resistance presents a formidable challenge. Previous studies have implicated a connection between post-sorafenib discontinuation rebound and the development of drug resistance, yet the underlying mechanism remains elusive.

Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages.

PANoptosis is an emerging form of regulated cell death (RCD) characterized by simultaneous activation of pyroptotic, apoptotic, and necroptotic signaling that not only participates in pathologies of inflammatory diseases but also has a critical role against pathogenic infections. Targeting PANoptosis represents a promising therapeutic strategy for related inflammatory diseases, but identification of inhibitors for PANoptosis remains an unmet demand. Baicalin () is an active flavonoid isolated from Scutellaria baicalensis Georgi (Huangqin), a traditional Chinese medicinal herb used for heat-clearing and detoxifying.

Abundance, characteristics and ecological risk assessment of microplastics in ship ballast water in ports around Liaodong Peninsula, China.

The development of the shipping industry has led to a large volume of ballast water discharge annually. This accelerates pollutants' transfer and dispersion, such as microplastics. Currently, empirical data on microplastics in ballast water are rarely available.

Deep-Learning-Guided Electrochemical Impedance Spectroscopy for Calibration-Free Pharmaceutical Moisture Content Monitoring.

The moisture content of pharmaceutical powders can significantly impact the physical and chemical properties of drug formulations, solubility, flowability, and stability. However, current technologies for measuring moisture content in pharmaceutical materials require extensive calibration processes, leading to poor consistency and a lack of speed. To address this challenge, this study explores the feasibility of using impedance spectroscopy to enable accurate, rapid testing of moisture content of pharmaceutical materials with minimal to zero calibration.

TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.

Sepsis is a common complication of infections that significantly impacts the survival of critically patients. Currently, effective pharmacological treatment strategies are lacking. Auranofin, known as an inhibitor of Thioredoxin reductase (TrxR), exhibits anti-inflammatory activity, but its role in sepsis is not well understood.