Influence of global warming and human activity on mercury accumulation patterns in wetlands across the Qinghai-Tibet Plateau.

Wetlands in the Qinghai-Tibet Plateau are a unique and fragile ecosystem undergoing rapid changes. We show two unique patterns of mercury (Hg) accumulation in wetland sediments. One is the 'surface peak' in monsoon-controlled regions and the other is the 'subsurface peak' in westerly-controlled regions.

Hydrogen-localization Transfer Regulation in 3D COFs Enhances Photocatalytic Acetylene Semi-hydrogenation to Ethylene.

In this work, a series of new crystalline three-dimensional covalent organic frameworks (3D COFs) based on [8+4] construction was designed and successfully realized efficient photocatalytic acetylene (C2H2) hydrogenation to ethylene (C2H4). By regulating the hydrogen-localization transfer effect in these 3D COFs，the Cz-Co-COF-H containing cobalt glyoximate active centers exhibited excellent C2H2-to-C2H4 performance, with an average C2H4 yield of 1755.33 μmol g-1 h-1 in pure C2H2, also showed near 100% conversion of C2H2 in 1% C2H2 contained crude C2H4 mixtures (industry-relevant conditions), and finally obtain polymer grade C2H4.

Evaluation of Generative Artificial Intelligence Models in Predicting Pediatric Emergency Severity Index Levels.

Objective: Evaluate the accuracy and reliability of various generative artificial intelligence (AI) models (ChatGPT-3.5, ChatGPT-4.0, T5, Llama-2, Mistral-Large, and Claude-3 Opus) in predicting Emergency Severity Index (ESI) levels for pediatric emergency department patients and assess the impact of medically oriented fine-tuning.

Identification of the G(3900) Structure as the P-Wave DD[over ¯]^{*}/D[over ¯]D^{*} Resonance.

The BESIII Collaboration recently performed a precise measurement of the e^{+}e^{-}→DD[over ¯] Born cross sections, and confirmed the G(3900) structure reported by BABAR and Belle with high significance. We identify the G(3900) as the first P-wave DD[over ¯]^{*}/D[over ¯]D^{*} molecular resonance. The experimental and theoretical identification of the P-wave dimeson state holds paramount importance in enhancing our comprehension of the nonperturbative QCD and few-body physics.

Precise identification of somatic and germline variants in the absence of matched normal samples.

Somatic variants play a crucial role in the occurrence and progression of cancer. However, in the absence of matched normal controls, distinguishing between germline and somatic variants becomes challenging in tumor samples. The existing tumor-only genomic analysis methods either suffer from limited performance or insufficient interpretability due to an excess of features.

Fibula flap reconstruction for maxillary stage 3 medication-related osteonecrosis of the jaw from recipient and donor site perspectives: a preliminary single-center study.

Background: While the surgical treatment of mandibular stage 3 medication-related osteonecrosis of the jaw (MRONJ) is well-documented, research on maxillary stage 3 MRONJ is limited. Antiresorptive medications can induce MRONJ and atypical femoral fracture (AFF), but their impact on the feasibility of using fibula flaps for reconstruction remains controversial. This study aimed to assess the surgical outcomes and functional recovery of fibula flap reconstruction for maxillary stage 3 MRONJ, considering both recipient and donor site outcomes.

Association of spring thermal forcing anomalies in the Tibetan Plateau with dust aerosol changes over the Taklamakan Desert.

The Tibetan Plateau (TP) is significantly influencing the climate and environmental evolution regionally and globally. Adjacent to the northwestern TP, the Taklimakan Desert (TD) experiences the unique pattern of dust aerosol variations due to the deep basin terrain. However, systematic studies on how TP climate change affects TD dust aerosol variations are lacking.

The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens.

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects of rodents remain unexplored, such as their potential in unconventional biomedical models, molecular underpinnings of intriguing complex phenotypes, adaptations to environment or climate change, and host-pathogen interactions and arms race evolution.

Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway.

Background/aims: Chemotherapy resistance in liver cancer is a major clinical issue, with CD147 playing a vital role in this process. However, the specific mechanisms underlying these processes remain largely unknown. This study investigates how CD147 internalization leads to cytoprotective autophagy, contributing to chemotherapy resistance in hepatocellular carcinoma (HCC).

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort.

Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.

Methods: We used Genetic Epidemiology Resource in Adult Health and Aging (GERA) cohort participants free of CHD at baseline (n = 60,568; 67 % female; 18 % non-European). The individual and joint associations of smoking, Mediterranean diet pattern, level of physical activity and polygenic risk with incident CHD were assessed using Cox regression adjusting for genetic ancestry and non-mediating risk factors.

GACT-PPIS: Prediction of protein-protein interaction sites based on graph structure and transformer network.

The prediction of protein-protein interaction sites (PPIS) is currently crucial for regulating many biological activities in cells and developing drugs for various diseases. Deep learning-based methods have been proposed for predicting PPIS, significantly reducing the manpower and time costs associated with traditional experimental methods such as yeast two-hybrid, mass spectrometry, and affinity purification. However, the predictive accuracy of these deep learning methods has not yet reached the expected level.

Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel - National Healthcare Safety Network, United States, 2023-24 Respiratory Virus Season.

The Advisory Committee on Immunization Practices (ACIP) recommends that health care personnel receive an annual influenza vaccine. In September 2023, ACIP recommended that everyone aged ≥6 months receive a 2023-2024 COVID-19 vaccine. Health care facilities, including acute care hospitals and nursing homes, report vaccination of health care personnel against influenza and COVID-19 to CDC's National Healthcare Safety Network (NHSN).

Genotyping single nucleotide polymorphisms in homologous regions using multiplex kb level amplicon capture sequencing.

Single nucleotide polymorphisms (SNPs) in homologous regions play a critical role in the field of genetics. However, genotyping these SNPs is challenging due to the presence of repetitive sequences within genome, which demand specific method. We introduce a new, mid-throughput method that simplifies SNP genotyping in homologous DNA sequences by utilizing a combination of multiplex kb level PCR (PCR size 2.

Simultaneous Detection of Eight Dairy-Derived Components Using Double-Tube Multiplex qPCR Based TaqMan Probe.

The authentication of milk and dairy products has great significance for food fraud. The present investigation entailed the development of a novel method that amalgamates the double-tube approach with multiplex real-time polymerase chain reaction (PCR) technology, incorporating TaqMan probes, to facilitate the high-throughput screening and detection of animal-derived constituents within milk and dairy products. Eight dairy-derived animal-specific primers and probes were designed for the mitochondrial () gene of eight dairy products, including cow, buffalo, yak, goat, sheep, horse, donkey, and camel.