Signal-off based dual-mode sensing platform for ultrasensitive detection of antibiotics in food samples.

Development of efficient and accurate detection methods for antibiotics is crucial for ensuring food safety and safeguarding human health. In this study, a dual-mode sensing platform was constructed by integrating photoelectrochemical (PEC) and surface-enhanced Raman scattering (SERS) techniques for the sensitive detection of kanamycin using an aptamer signal conversion strategy which was based on the CN/MXene-gold nanoparticles heterojunction. The sensitive dual-mode sensing platform enabled detection of kanamycin, with linear response ranges of 10 to 10 nM for PEC with a detection limit (LOD) of 0.

Full-Color Emissive Zirconium-Organic Frameworks Constructed via in Situ "One-Pot" Single-Site Modification for Tryptophan Detection and Energy Transfer.

Organic linker-based luminescent metal-organic frameworks (LMOFs) have received extensive studies due to the unlimited species of emissive organic linkers and tunable structure of MOFs. However, the multiple-step organic synthesis is always a great challenge for the development of LMOFs. As an alternative strategy, in situ "one-pot" strategy, in which the generation of emissive organic linkers and sequential construction of LMOFs happen in one reaction condition, can avoid time-consuming pre-synthesis of organic linkers.

Reticular Chemistry and In Situ "One-Pot" Strategy: A Dream Combination to Construct Metal-Organic Frameworks.

The establishment of reticular chemistry has significantly facilitated the development of porous materials, especially for metal-organic frameworks (MOFs). On the other hand, as an alternative approach, in situ "one-pot" strategy has been explored as a promising approach to constructing MOFs, in which the synthesis of organic linkers and the sequential construction of MOFs are integrated into one solvothermal condition. This strategy can efficiently avoid the limitations faced in the traditional construction method, such as time-consuming organic synthesis and multiple separation and purification.

Porous organic polymers assisted aptamer signal amplification for enhanced photoeletrochemical detection of MUC1.

Mucin1 (MUC1) is an extensively glycosylated transmembrane protein that is widely distributed and overexpressed on the surface of cancer cells, playing an important role in tumor occurrence and metastasis. Therefore, highly sensitive detection of MUC1 is of great significance for early diagnosis, treatment monitoring, and prognosis of cancer. Here, an ultra-sensitive photoelectrochemical (PEC) sensing platform was developed based on an aptamer amplification strategy for highly selective and sensitive detection of MUC1 overexpressed in serum and on cancer cell surfaces.

Recyclable Au@R-FeO/g-CN substrates for rapid SERS detection and degradation of multiple pollutants.

Developing a Surface-enhanced Raman spectroscopy (SERS) method with excellent detecting ability, good recyclability and analyzing multiple pollutants rapidly are critical for evaluation of water quality in emergency pollution affairs. While constructing a multifunctional substrate with these characteristics to realize the application of SERS in water quality monitoring remains a challenge. In this work, a reusable Au@R-FeO/g-CN SERS substrate is prepared by loading Au nanoparticles (Au NPs) on FeO nanorings (R-FeO) and the formed Au@R-FeO is further combined with g-CN nanosheets through a simple electrostatic assembly method.

Reticular chemistry guided precise construction of zirconium-pentacarboxylate frameworks with 5-connected Zr clusters.

Zirconium-based metal-organic frameworks (Zr-MOFs) have been extensively studied due to their very rich structural chemistry. The combination of nearly unlimited carboxylic acid-based linkers and Zr clusters with multiple connectivities has led to diverse structures and specific properties of resultant Zr-MOFs. Herein, we demonstrate the successful use of reticular chemistry to construct two novel Zr-MOFs, HIAM-4040 and HIAM-4040-OH, with zfu topology.

Ag-MXene as peroxidase-mimicking nanozyme for enhanced bacteriocide and cholesterol sensing.

Reactive oxygen species (ROS) are ideal alternative antibacterial reagents for rapid and effective sterilization. Although a variety of ROS-based antimicrobial strategies have been developed, many are still limited by their inefficiency. Herein, we report the synthesis of the Ag-MXene nanozyme, which have superior peroxidase-like activity for antibacterial applications.

Reticular Chemistry with Art: A Case Study of Olympic Rings-Inspired Metal-Organic Frameworks.

Herein, we demonstrate the successful utilization of reticular chemistry as an excellent designing strategy for the deliberate construction of a zirconium-tetracarboxylate metal-organic framework (MOF) inspired by the Olympic rings. HIAM-4017, with an unprecedented (4,8)-c underlying net topology termed , was developed via insightful reconstruction of the rings and judicious design of a nonsymmetric organic linker. HIAM-4017 exhibits high porosity and excellent chemical and thermal stability.

Nanozyme-mediated signal amplification for ultrasensitive photoelectrochemical sensing of Staphylococcus aureus based on Cu-CN-TiO heterostructure.

Food-borne pathogens are one of the leading causes of food poisoning, which vigorously affect food safety and human health. Therefore, the development of early and rapid detection methods for food pollution evaluation is the key to food safety and quality control. Herein, a simple and inexpensive photoelectrochemical (PEC) sensor is developed for highly selective and ultrasensitive detection of Staphylococcus aureus (S.

Ultrasensitive SERS detection of exhaled biomarkers of lung cancer using a multifunctional solid phase extraction membrane.

The construction and clinical application of a surface-enhanced Raman scattering (SERS) platform for the early diagnosis of lung cancer could improve the survival rate of patients and would be of great significance. Nevertheless, a sensitive and reusable method for the detection of aldehydes, as biomarkers of lung cancer, in exhaled breath is still an enormous challenge. Aldehydes generally have a low cross section in Raman scattering and have a weak specific affinity to plasmonic nanoparticle surfaces, meaning that sensing them at low concentrations is incredibly difficult.

Combined Paper Centrifugal Chromatographic Separation and SERS Detection for Multicomponent Substances.

The separation and chemical analysis of mixtures in an emergency situation represent major challenges, especially in remote or poverty-stricken areas. A novel method was developed for the rapid separation and detection of multiple components via paper centrifugal chromatography, which costs as little as $2.26 US.

In situ food-borne pathogen sensors in a nanoconfined space by surface enhanced Raman scattering.

The incidence of disease arising from food-borne pathogens is increasing continuously and has become a global public health problem. Rapid and accurate identification of food-borne pathogens is essential for adopting disease intervention strategies and controlling the spread of epidemics. Surface-enhanced Raman spectroscopy (SERS) has attracted increasing interest due to the attractive features including simplicity, rapid measurement, and high sensitivity.

A disposable paper-based hydrophobic substrate for highly sensitive surface-enhanced Raman scattering detection.

Detection of target analytes with high sensitivity and reproducibility remains a challenge for surface-enhanced Raman scattering (SERS) due to the lack of cost-effective and highly sensitive substrates. In this study, a hydrophobic SERS substrate capable of concentrating nanoparticles and analytes was prepared by spin-coating lubricating liquid onto commercial paper. The condensation effect of the paper-based hydrophobic substrate induced aggregation of gold nanoparticles (Au NPs) to generate ''hot spots'' for SERS and to drive analytes to the hot-spot areas for more sensitive detection.

Extraction of Two-Dimensional Aluminum Alloys from Decagonal Quasicrystals.

Atomically thin metallic alloys are receiving increased attention due to their prospective applications as interconnects/contacts in two-dimensional (2D) circuits, sensors, and catalysts, among others. In this work, we demonstrate an easily scalable technique for the synthesis of 2D metallic alloys from their 3D quasicrystalline precursors. We have used aluminum (Al)-based single-phase decagonal quasicrystal AlCoCu alloy to extract the corresponding 2D alloy structure.

Fabrication of paper-based SERS substrates by spraying silver and gold nanoparticles for SERS determination of malachite green, methylene blue, and crystal violet in fish.

A disposable surface-enhanced Raman scattering (SERS) substrate was prepared by successively spraying silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) onto commercial filter paper using an inexpensive consumer sprayer. The strong surface enhancement of AgNPs and chemical stability of AuNPs can be advantageously combined. The substrate exhibited excellent SERS activity for malachite green (MG), methylene blue (MB), and crystal violet (CV) under 785-nm excitation, with limits of detection (LODs) of 4.

[Isolation and screening of a phytate phosphate-solubilizing Paenibacillus sp. and its growth-promoting effect on rice seeding].

The phosphate-solubilizing medium plate screening and heavy metal resistance rescreening were used to isolate a phosphate-solubilizing bacterium (coded ZLT11) from the rhizosphere of Mikania micrantha. Results from 16S rRNA gene sequence analysis revealed that the strain ZLT11 belonged to Paenibacillus sp. The amount of phosphorus solubilized from calcium phytate and phytic acid by the ZLT11 was 84.

Sensitive detection of telomerase activity in cells using a DNA-based fluorescence resonance energy transfer nanoprobe.

Telomerase activity is inhibited in normal somatic cells but abnormally high in the majority of cancer cells. Maintenance of active telomerase in cancer cells promotes proliferation and immortalization. With the difference in telomerase activity between cancer and normal cells in mind, we designed a nanoprobe based on quantum dot (QD) and fluorescence resonance energy transfer (FRET).

Recyclable three-dimensional Ag nanorod arrays decorated with O-g-CN for highly sensitive SERS sensing of organic pollutants.

A three-dimensional (3D) substrate was developed by assembling a monolayer of graphitic carbon nitride (O-g-CN) on Ag nanorod arrays (Ag NRs) for sensitive and recyclable surface enhanced Raman scattering (SERS) detection. The prepared Ag NRs/O-g-CN substrate not only generated a significant Raman enhancement effect as a result of the strong π-π stacking interaction between O-g-CN and the analytes but also possessed excellent self-cleaning property via visible-light irradiation that was attributed to its outstanding catalytic performance. Highly sensitive SERS detection could be achieved with a LOD of 8.

Thin layer chromatography combined with surface-enhanced raman spectroscopy for rapid sensing aflatoxins.

A fast and facile method was developed for on-site detection of aflatoxins (AFs) in moldy agricultural products using thin layer chromatography combined with surface-enhanced Raman spectroscopy (TLC-SERS). Four different AFs were successfully separated by TLC and then a small portable Raman spectrometer, with gold colloids as the SERS-active substrate, was applied to identify the separated spots. TLC-SERS application to on-site detection of AFs was systematically investigated.

Facile fabrication of ternary TiO-gold nanoparticle-graphene oxide nanocomposites for recyclable surface enhanced Raman scattering.

A bi-functional ternary nanocomposite was developed by decorating TiO and gold nanoparticles on the reduced graphene oxide nanosheets (TiO-Au-rGO) for recyclable surface enhanced Raman scattering (SERS) detection. TiO-Au-rGO nanocomposites have been shown to demonstrate the superior SERS performances, which can be used for highly sensitive detection of rhodamine 6 G with a limit of detection of 1.2 × 10 M.

Removal of Antibiotics From Water with an All-Carbon 3D Nanofiltration Membrane.

Recent industrial developments and increased energy demand have resulted in significantly increased levels of environmental pollutants, which have become a serious global problem. Herein, we propose a novel all-carbon nanofiltration (NF) membrane that consists of multi-walled carbon nanotubes (MWCNTs) interposed between graphene oxide (GO) nanosheets to form a three-dimensional (3D) structure. The as-prepared membrane has abundant two-dimensional (2D) nanochannels that can physically sieve antibiotic molecules through electrostatic interaction.

Highly Reproducible Ag NPs/CNT-Intercalated GO Membranes for Enrichment and SERS Detection of Antibiotics.

The increasing pollution of aquatic environments by antibiotics makes it necessary to develop efficient enrichment and sensitive detection methods for environmental antibiotics monitoring. In this work, silver nanoparticles and carbon nanotube-intercalated graphene oxide laminar membranes (Ag NPs/CNT-GO membranes) were successfully prepared for enrichment and surface-enhanced Raman scattering (SERS) detection of antibiotics. The prepared Ag NPs/CNT-GO membranes exhibited a high enrichment ability because of the π-π stacking and electrostatic interactions of GO toward antibiotic molecules, which enhanced the sensitivity of SERS measurements and enabled the antibiotics to be determined at sub-nM concentrations.

SERS nanoprobes for the monitoring of endogenous nitric oxide in living cells.

Nitric Oxide (NO) is a significant gaseous signalling molecule in various pathological and physiological pathways, whereas many of its functions are still ambiguous in part because of the shortage of powerful detection approaches. Herein, we present a type of reaction-based surface-enhanced Raman scattering (SERS) nanoprobes, o-phenylenediamine-modified gold nanoparticles (AuNPs/OPD), to detect the level of the endogenous NO in living cells. The detection is achieved through the SERS variation of AuNPs/OPD caused by the reaction between NO and OPD on the surface of AuNPs.