Application of a novel gastro-laryngeal mask in upper gastrointestinal endoscopy surgery: A pilot randomized clinical trial.

Background: The Gastro-Laryngeal Mask (Jcerity Endoscoper Airway) is a new airway management technique utilized in patients undergoing upper gastrointestinal endoscopy surgery under general anesthesia, but evidence of its effectiveness and safety is scarce.

Objective: To assess the success rate of insertion, cardiovascular response, airway pressure, time taken for placement, nausea or vomiting, pharyngodynia, and other complications of using the new type of back-open gastroscopy laryngeal mask.

Methods: We screened 1401 patients; 105 were ineligible, and 40 declined to participate.

Establishment and characterization of a new intestinal-type ampullary carcinoma cell line, DPC-X3.

Ampullary carcinoma (AC) of the intestinal type represents a distinct variant within the broader category of ampullary neoplasms. The scarcity of pertinent cellular models has constrained investigations centered on this particular malignancy. This research effectively generated a cell line (CL) of intestinal-type AC (DPC-X3).

Overcoming Gas Mass Transfer Limitations Using Gas-Conducting Electrodes for Efficient Nitrogen Reduction.

Electrocatalytic nitrogen reduction reaction (NRR) is a very attractive strategy for ammonia synthesis due to its energy savings and sustainability. However, the ammonia yield and Faraday efficiency of electrocatalytic nitrogen reduction have been challenges due to low nitrogen solubility and competitive hydrogen evolution reaction (HER) in electrolyte solution. Herein, inspired by the asymmetric wetting behavior, i.

[Identification and expression profiling of Dof transcription factor family in Aesculus chinensis].

Aesculus chinensis is an important medicinal and horticultural plant. Its dried mature seeds, known as "Suoluozi", are a well-known traditional Chinese medicine. Aescins are its main active components, possessing multiple pharmacological activities such as anti-inflammatory and anti-exudative effects.

Modification of Inca peanut albumin-polyphenol conjugates by chitosan through laccase catalysis: Structural, interfacial, and functional properties.

As a green method, enzyme crosslinking can catalyze chitosan (CS) to improve further the structural, interfacial, and functional properties of Inca peanut albumin (IPA)-polyphenols. However, the structural impact of laccase-catalyzed CS on different IPA-polyphenol conjugates has not been reported. Results revealed that enzymatic cross-linking of IPA-gallic acid (GA) and IPA- (-)-epigallocatechin-3-gallate (EGCG) with CS resulted in a decrease in α-helices, an increase in β-helices, and a more ordered structure.

Application and Output Performance Comparison of Janus and Traditional Transition Metal Chalcogenides in Ytterbium-Doped Fiber Lasers.

Janus transition metal disulfide (TMD) monolayers have two distinct carbon surfaces that break the inherent ground external mirror symmetry. When compared to traditional TMD materials, Janus TMDs not only inherit the advantages of traditional TMDs but also have new characteristics that are different from those of traditional TMDs. This paper describes the development of a stable passive Q-switched ytterbium-doped fiber laser (YDFL) with operating wavelengths of 1032.

Oral Curcumin through Mesoporous Silica Nanomaterials with Distinct Morphologies: Synthesis, Characterization, Biosafety Evaluation, and Antioxidant Activity .

Antioxidant play a crucial role in the prevention and treatment of diseases associated with oxidative stress. Curcumin (CUR), as a natural antioxidant, exhibits numerous therapeutic properties, including antioxidant, anti-inflammatory, antibacterial, and antitumor activities. However, its limited bioavailability and poor water solubility hinder its application as an effective antioxidant.

Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer.

Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium animalis ssp. lactis BX-245 (BX-245), in alleviating tumor burden in CRC mice induced by azoxymethane and dextran sodium sulfate.

The Effect of TiO on the Dielectric Performance of ZrO and NbO Pre-Doped CaCuTiO Ceramics.

In this work, the effects of different sintering temperatures and TiO concentrations on the dielectric properties of ZrO and NbO pre-doped CaCuTiO (CCTO) ceramics were investigated. These doped ceramics were sintered at temperatures of 1020, 1030, and 1040 °C, exhibiting the lowest dielectric loss of 0.01, which consistently remained below 0.

Efficient and Stable Deep-Blue 0D Copper-Based Halide TEACuI with Near-Unity Photoluminescence Quantum Yield for Light-Emitting Diodes.

Achieving deep-blue light with high color saturation remains a critical challenge in the development of white light-emitting diode (LED) technology, necessitating luminescent materials that excel in efficiency, low toxicity, and stability. Here, we report the synthesis of [N(CH)]CuI (TEACuI) single crystals (SCs), which exhibit deep-blue photoluminescence (PL) at 450 nm. These crystals are characterized by a significant Stokes shift of 180 nm, a long lifetime of 1.

Riluzole Reverses Blood-Testis Barrier Loss to Rescue Chemotherapy-Induced Male Infertility by Binding to TRPC.

Cancer treatments, including cytotoxic therapy, often result in male infertility, necessitating the development of safe and effective strategies to preserve male reproductive potential during chemotherapy. Notably, our study uncovers the potential of repurposing riluzole, an FDA-approved drug for amyotrophic lateral sclerosis (ALS), in enhancing spermatogenesis. Hence, this research aims to explore the feasibility of utilizing riluzole to alleviate male infertility induced by busulfan (BSF), a commonly used chemotherapy drug.

Rosthornin B alleviates inflammatory diseases via directly targeting NLRP3.

Aberrant activation of the NLRP3 inflammasome contributes to the evolution of diverse inflammatory diseases. Inhibition of the NLRP3 inflammasome has been proven to be an effective treatment strategy for NLRP3-driven diseases. This study revealed that multiple natural diterpenes from Isodon plants can inhibit the NLRP3 inflammasome, among which Rosthornin B (Ros B) exhibited the best inhibitory effect, with an IC of 0.

Association of grip strength, sleep duration, and comorbidities with depressive symptoms in middle-aged and older patients with chronic lung diseases: a cross-sectional network analysis based on CHARLS data.

Background: Depressive symptoms are prevalent among patients with chronic lung diseases (CLDs) and adversely impact their quality of life. This study aims to explore the association of grip strength (GS), sleep duration, and comorbidities with depressive symptoms in patients with CLDs, with an in-depth analysis of the underlying mechanisms.

Methods: Based on data from the China Health and Retirement Longitudinal Study (CHARLS), this study included participants aged 45 and above with diagnosed CLDs.

Longitudinal Analysis of Risk Factors for Pulmonary Function Decline in Chronic Lung Diseases Over Five Years.

Objective: Chronic lung diseases (CLDs) are a major global health concern, characterized by a progressive decline in pulmonary function that severely impacts quality of life. It is essential to identify and predict the primary risk factors for CLDs. This study aims to establish a predictive model to assist healthcare providers in the early identification of high-risk patients and timely interventions and treatment options.

Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy.

Type 2 Diabetes Mellitus (T2DM) exacerbates periodontal disease lesions, and human periodontal ligament stem cells (PDLSCs) depletion may be the key to periodontal healing impair by T2DM. This study aims to explore the mechanism of PDLSCs depletion in diabetes periodontitis (DP). Firstly, we observed aggravated periodontal destruction in the DP animal model, accompanied by oxidative damage and accumulation of senescent cells.

Association Between Melanoma Metastasis and Metabolic Syndrome: A Cross-Sectional Study in a Chinese Population.

Metabolic syndrome (MetS) remains a significant global public health concern. However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanoma patients who had not undergo systemic therapy.

DNA quality and STR success rate in different formalin-fixed tissues.

Formalin-fixed tissues possess irreplaceable value as a source of DNA for identification, especially when fresh samples are unavailable. Nonetheless, extracting and amplifying DNA from these tissues is challenging, primarily due to formaldehyde-induced cross-linking and nucleic acid fragmentation. In this study, two pre-extraction treatments, gradual dehydration using ethanol and pre-digestion heat treatments, and three DNA extraction methods, the Chelex-100 method, TIANamp FFPE DNA Kit, and ML Ultra-micro DNA extraction kit, were utilized to optimize DNA extraction from different tissues, which were fixed in 4% unbuffered formalin for different durations.

The TFEB activator clomiphene citrate ameliorates lipid metabolic syndrome pathology by activating lipophagy and lipolysis.

The balance between lipid synthesis and lipid catabolism is critical to maintain energy homeostasis. Lipophagy and lipolysis are two important pathways for lipid selective catabolism. Defects in lipophagy and lipolysis are linked to lipid metabolic diseases.

New MgSiO_{4}H_{2} Phases as Potential Primary Water Carriers into the Deep Earth.

Dense hydrous magnesium silicate MgSiO_{4}H_{2} is widely regarded as a primary water carrier into the deep Earth. However, the stability fields of MgSiO_{4}H_{2} based on the prevailing structure model are narrower than experimental results at relevant pressure and temperature (P-T) conditions, casting doubts about this prominent mineral as a water carrier into the great depths of the Earth. Here, we report on an advanced structure search that identifies two new crystal structures, denoted as α- and β-MgSiO_{4}H_{2}, that are stable over unprecedentedly wide P-T conditions of 17-68 GPa and up to 1860 K, covering the entire experimentally determined range.