Cerebral white matter damage in patients with end-stage kidney disease associates with cognitive impairment.

Background: Damage to brain white matter often occurs in individuals with chronic kidney disease, which might be related to their cognitive decline. This study aims to investigate tract-specific white matter damage in patients with end-stage kidney disease by using fixel-based analysis.

Methods: Images of 31 end-stage kidney disease patients and 16 normal controls (aged: 61.

Integrating Ni(OH) Nanoparticles on CdS for Efficient Noble-Metal-Free Photocatalytic H Evolution.

Photocatalytic hydrogen evolution using inexhaustible clean solar energy is considered as a promising strategy. In order to build an efficient photocatalytic hydrogen production system to satisfy the demands of practical applications, it is of great significance to design photocatalysts that offer high activity, low cost, and high stability. Herein, a series of cheap CdS/Ni(OH) composite photocatalysts were designed and synthesized using the hydrothermal method.

Breaking the Cycle: Perceived Control and Teacher-Student Relationships Shield Adolescents from Bullying Victimization over Time.

Background: Bullying victimization remains a grave issue in early adolescence. However, existing research often lacks a longitudinal perspective and sufficient attention to protective factors, particularly the dynamic role of teacher-student relationships.

Objective: This study explores the longitudinal protective mechanisms against bullying victimization, focusing on the roles of perceived control and teacher-student relationships.

Using electrical resistivity techniques (ERT and SP) for nondestructive detection of seepage channels at the Leitai heritage site, China.

Seepage accelerates the weathering and destruction of cultural heritage sites, posing a major preservation challenge, while the concealed nature of seepage channels complicates their detection due to noninvasive requirements. In this study, we applied a comprehensive geophysical approach, integrating electrical resistivity tomography (ERT) and self-potential (SP) techniques, to image seepage channels within the Leitai heritage site. These potential seepage channels have already caused a collapse pit measuring 3.

Quinoline: A Novel Solution for Next-Generation Pesticides, Herbicides, and Fertilizers.

Quinoline is a nitrogen-containing heterocycle compound widely used in the medical industry for its pharmacological properties, such as its antimalarial, antimicrobial, antiparasitic, anti-inflammatory, and anticancer activities. Beyond its medical significance, quinoline shows promising applications in agriculture as a safe and effective pesticide, herbicide, and fertilizer. This review explores the evolution of quinoline research, beginning with its history and synthesis and transitioning to its biological activities and their relevance in agriculture.

Zanubrutinib plus R-CHOP for the treatment of newly diagnosed double-expressor lymphoma: A phase 2 clinical study.

Background: Double-expressor lymphoma (DEL) has a poorer prognosis than other subtypes of diffuse large B-cell lymphoma (DLBCL). This study is a multicenter, prospective, single-arm, phase 2 clinical study initiated by investigators to evaluate the efficacy and safety of combined zanubrutinib with R-CHOP, which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone for patients with DEL (stage II or more), as well as to explore factors related to efficacy preliminarily.

Methods: From November 2020 to July 2022, 48 newly diagnosed patients were enrolled.

Therapeutic potential of -based Eefooton in patients with chronic kidney disease: from clinical to bench study.

Chronic kidney disease (CKD) is a global health concern, and recent clinical evidence suggests the potential of traditional Chinese medicine (TCM) to slow CKD progression. This offers alternative strategies for CKD patients, mitigating risks related to polypharmacy and adverse drug reactions. Our self-controlled, prospective study aims to assess the impact of Eefooton (EFT), a TCM-based regimen, on kidney health in stage 3-5 CKD patients.

Efficient genome editing in medaka () using a codon-optimized SaCas9 system.

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, belonging to the type II CRISPR/Cas system, is an effective gene-editing tool widely used in different organisms, but the size of Cas9 (SpCas9) is quite large (4.3 kb), which is not convenient for vector delivery. In this study, we used a codon-optimized Cas9 (SaCas9) system to edit the tyrosinase (, oculocutaneous albinism II (), and paired box 6.

A self-forming bone membrane generated by periosteum-derived stem cell spheroids enhances the repair of bone defects.

The periosteum, a highly specialized thin tissue, is instrumental in contributing to as much as 70% of early bone formation. Recognizing the periosteum's vital physiological roles, the fabrication of a biomimetic periosteum has risen as an auspicious strategy for addressing extensive bone defects. In the study, we obtained such biomimetic periosteum by utilizing periosteum-derived stem cells (PDSCs) spheroids.

Association between diabetes mellitus and trochanteric bone mineral density in individuals with osteoporotic fractures: a retrospective study.

Background: The relationship between diabetes mellitus (DM) and bone mineral density (BMD) in patients with osteoporotic fractures (OPFs) remains complex and heterogeneous, specifically between the genders. This study aimed to explore the association between diabetes status and trochanteric BMD in a cohort of patients with OPFs and elucidate the differences between male and female patients.

Methods: This retrospective analysis was performed on 710 admitted patients aged 50 years or older with OPFs.

PCSK9 in T-cell function and the immune response.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) was first reported in 2003 and confirmed to be strongly associated with familial hypercholesterolemia. Small-molecule inhibitors targeting PCSK9 provide an effective and safe method for managing hypercholesterolemia and reducing the cardiovascular risk. In recent years, increasing evidence has indicated other important roles for PCSK9 in inflammation, tumors, and even immune regulation.

GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis.

Liver transplantation is currently recognized as the most effective treatment for severe liver diseases. Although survival rates after liver transplantation have improved, rejection of the transplanted liver remains a significant cause of morbidity and transplant failure in patients. Our team previously discovered a close association between high GBP1 expression and acute rejection reactions following liver transplantation.

The glutathione S-transferase BnGSTU12 enhances the resistance of Brassica napus to Sclerotinia sclerotiorum through reactive oxygen species homeostasis and jasmonic acid signaling.

Sclerotinia sclerotiorum is a severe disease that affects rapeseed (Brassica napus), resulting in significant yield losses. In previous study, we identified the candidate GLUTATHIONE S-TRANSFERASE (GST) gene, BnGSTU12, associated with sclerotiorum stem resistance and the expression levels of BnGSTU12 in resistant lines were higher than that in susceptible lines. We analyzed the function of the BnGSTU12 during S.

Changes in Occlusal Contacts upon the Cementation of Zirconia Crowns with Different Cement Spacers.

Occlusion plays a crucial role in the long-term success and functionality of dental restorations. The purpose of this study was to investigate the changes in occlusal contacts upon the cementation of zirconia crowns with different cement spacer settings in computer-aided design and computer-aided manufacturing (CAD-CAM) software (3Shape Dental System version 2.102.

Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell.

Background: Diabetes mellitus (DM) can cause severe complications, including diabetic foot ulcers (DFU). There is a significant gap in understanding the single-cell ecological atlas of DM and DFU tissues.

Methods: Single-cell RNA sequencing data were used to create a detailed single-cell ecological landscape of DM and DFU.

THE STING AGONIST VB-85247 INDUCES DURABLE ANTITUMOR IMMUNE RESPONSES BY INTRAVESICAL ADMINISTRATION IN A NON-MUSCLE INVASIVE BLADDER CANCER.

Bacillus Calmette-Guerin (BCG) is the current standard of care for non-muscle invasive bladder cancer (NMIBC), but recurrence is common. Additional therapeutic options are a major unmet medical need for treating unresponsive patients. Stimulator of Interferon Genes (STING) plays a central role in mounting innate and adaptive immune responses to tumor cells, and activation of STING is a promising immunotherapeutic approach.

Exploring the mechanism of berberine treatment for atherosclerosis combined with non-alcoholic fatty liver disease based on bioinformatic and experimental study.

Atherosclerosis (AS) and Non-alcoholic fatty liver disease (NAFLD) are chronic metabolic disorders with high prevalence and significant health impacts. Both conditions share common pathophysiological pathways including abnormal lipid metabolism and inflammation. Berberine (BBR), an isoquinoline alkaloid, is known for its beneficial effects on various metabolic and cardiovascular disorders.

Highly Stable Lanthanide-Organic Frameworks Based on {LnO} Clusters with Photocatalytic Reduction of CO to CO.

Metal-organic frameworks (MOFs) with adjustable structures, diverse chemical functionalities, and excellent CO capture ability have shown important potential application in the photocatalytic reduction of CO to valuable fuel to curb the energy crisis. In this work, a series of new isostructural lanthanide-organic frameworks based on hexanuclear {LnO} clusters, {(DMA) [Ln(μ-OH)(HO)(SBTC)]} (Ln-MOFs, Ln = Eu, Dy, Gd, Tb, Yb; HSBTC = 5,5'-(ethene-1,2-diyl) di-isophthalic acid; DMA = dimethylamine cation) were synthesized by the solvothermal method. Ln-MOFs were metal-organic frameworks formed by {Ln(μ-OH)} clusters and poly(carboxylic acid) ligands HSBTC, which exhibited excellent photocatalytic properties for the reduction of CO to CO.

Advancements in the Treatment of Atherosclerosis: From Conventional Therapies to Cutting-Edge Innovations.

Atherosclerosis is a leading cause of morbidity and mortality worldwide, driven by a complex interplay of lipid dysregulation, inflammation, and vascular pathology. Despite advancements in understanding the multifactorial nature of atherosclerosis and improvements in clinical management, existing therapies often fall short in reversing the disease, focusing instead on symptom alleviation and risk reduction. This review highlights recent strides in identifying genetic markers, elucidating inflammatory pathways, and understanding environmental contributors to atherosclerosis.

Anterior segment OCT for imaging PAUL glaucoma implant patch grafts: a useful method for follow-up and risk management.

Aim: To evaluate a useful, non-contact method for the follow-up of pericardium patch graft changes in patients undergoing PAUL Glaucoma Implant (PGI) surgery using high-resolution anterior segment optical coherence tomography (OCT) to predict tube erosions.

Methods: Prospective analysis over six months of tube pericardium patch graft thickness of PGI surgical cases at the University Eye Hospital Bonn, Germany, from November 2021 to August 2022. In all eyes, Tutopatch (RTI Surgical, United States) pericardium was used to cover the implant intra-operatively.

Pirfenidone microcrystals for pulmonary delivery: Regulation of the precipitation behavior in the supercooled droplet.

Pirfenidone (PFD) is one of the first-line drugs for treating idiopathic pulmonary fibrosis, while directly delivering PFD to lung showed better efficiency. However, PFD is a non-glass former and easily precipitates into larger-sized crystals that are undesirable for pulmonary delivery. Hence, the fabrication of PFD particles with pulmonary delivery efficiency remains challenging.

Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts.

Background: Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown. This research aimed to exclude the regional heterogeneity to quantify the exposure-response association between multimorbidity and depression in older adults worldwide.

Method: We collected 23,947 participants aged 65 years or above from six large prospective cohorts from developed and developing countries, including Mexico, South Korea, Europe, America, China, and England.

The interpersonal neural coupling in group creative ideation.

Group creative ideation, the capacity of group to produce novel and useful ideas, is essential for navigating challenges and embracing opportunities. Despite its significance, research to decode its neurocognitive underpinnings utilizing interpersonal neuroscience paradigm has just commenced, linking group creative ideation to interpersonal neural coupling. In this perspective, we propose an interpersonal neural coupling in group creative ideation framework, which suggests that group creative ideation is supported by interpersonal neural coupling within three interrelated systems: cognitive, affective, and physical alignments.