Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association.

Identifying dependable prognostic indicators is essential for the efficient management of metabolic dysfunction-associated steatotic liver disease (MASLD). The index of hemoglobin glycation (HGI) has been demonstrated to be closely linked to the onset and advancement of MASLD. Currently, no studies have investigated the relationship between HGI and mortality rates among MASLD patients.

The Correlations between Volume Loss of Temporal and Subcortical Functional Subregions and Cognitive Impairment at Various Stages of Cognitive Decline.

Background: The relationship between subregion atrophy in the entire temporal lobe and subcortical nuclei and cognitive decline at various stages of Alzheimer's disease (AD) is unclear.

Methods: We selected 711 participants from the AD Neuroimaging Initiative (ADNI) database, which included 195 cases of cognitively normal (CN), 271 cases of early Mild cognitive impairment (MCI) (EMCI), 132 cases of late MCI (LMCI), and 113 cases of AD. we looked at how subregion atrophy in the temporal lobe and subcortical nuclei correlated with cognition at different stages of AD.

Optical logic array: a photonic solution towards universal computing.

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Cortex Dictamni induces retinitis pigmentosa in zebrafish by inhibiting pde6a post-transcriptional activity via mmu-mir-6240-p3_2.

Ethnopharmacological Relevance: Cortex Dictamni (CD) is the dried root skin of Dictamnus dasycarpus Turcz, widely used in the field of traditional Chinese medicine. Recent adverse reactions to CD limited the clinical application in combination with other traditional Chinese medicines.

Aim Of The Study: To investigate the retinitis pigmentosa (RP) effects of CD using the zebrafish model and elucidate the underlying molecular mechanism of CD-induced RP in zebrafish.

Delta corticomedullary apparent diffusion coefficient on MRI as a biomarker for prognosis in IgA nephropathy.

Objectives: To explore the association of the cortico-medullary difference in apparent diffusion coefficient (ΔADC) with clinicopathological parameters of disease activity at the time of biopsy, and with the prognositic risk stratification in IgA nephropathy (IgAN) patients.

Methods: We included 112 patients with biopsy-proven IgAN who measured ΔADC. Patients underwent a kidney biopsy and diffusion-weighted magnetic resonance imaging within one week of the biopsy.

Green carbon dots derived from alleviate ovalbumin-induced allergic rhinitis.

Background: Allergic rhinitis (AR) affects up to 40% of the population, leading to significant healthcare expenditures. Current mainstream treatments, while effective, can lead to side effects and do not address the underlying immunological imbalances. (ZRC), the partially charred product of (ZR), has been widely used clinically in China since ancient times to treat respiratory disorders.

One-Step Electrochemical Modification of PEDOT:PSS/PBNPs Hybrid Hydrogel on the Screen-Printed Electrode Surface for Highly Sensitive Detection of Creatinine.

Creatinine (CRE) is frequently measured in clinical practice due to its recognized significance as a pivotal biomarker across a spectrum of renal and cardiovascular disorders. However, the rapid and accurate detection of CRE for assessing kidney and muscle functions remains challenging. Here, we prepared the poly(3,4ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogel uniformly loaded with Prussian blue nanoparticles (PBNPs) via a one-step metal-assisted electrochemical modification method on the screen-printed electrode for ultrasensitive CRE detection.

Exploring the diversity of sexual acts in Chinese men who have sex with men and its impacts on the risk of HIV and sexually transmitted infections.

Objectives: High-risk sexual behaviour contributes to sexually transmitted infections (STIs), but the diversity of sexual acts in men who have sex with men (MSM) was understudied. We aimed to identify the diversity of sexual acts in Chinese MSM and its impacts on HIV/STI risk.

Study Design: Cross-sectional study.

Evaluation of renal oxygenation and perfusion in patients with chronic kidney disease: a preliminary prospective study based on functional magnetic resonance.

Background: Renal hypoxia and ischemia significantly contribute to chronic kidney disease (CKD) progression, underscoring the need for noninvasive quantitative assessments. This study employs blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and arterial spin labeling (ASL) MRI to comprehensively evaluate renal oxygenation and blood flow in CKD patients.

Methods: Forty-two CKD patients across stages 1-5 and ten healthy volunteers underwent simultaneous BOLD-MRI and ASL-MRI.

In-situ preparation of CeO@MIL-88B nanocomposite for improving "turn-on" fluorescent sensing toward Thiabendazole.

A novel "turn-on" fluorescent sensor of CeO@MIL-88B was constructed successfully via the facile in-situ strategy. The as-obtained CeO@MIL-88B could be used for effectively detecting the analyte of thiabendazole (TBZ) by luminescence enhancement, which limit of detection (LOD) was as low as 0.294 μM (nearly 10.

The embryological characteristics and clinical outcomes of oocytes with indented zona pellucida.

Background: Our study aimed to investigate the embryological characteristics and clinical outcomes of oocytes with indented zona pellucida (iZP).

Methods: Cases with all oocytes containing iZP were compared with subjects whose oocytes presented morphologically normal ZP (nZP, controls), regarding embryological and clinical outcomes. Cases consisted of 56 subjects that underwent 109 assisted reproductive treatment (ART) cycles, and controls were made of 574 patients that were enrolled in 1095 ART cycles.

Aneuploidy rates and clinical pregnancy outcomes after preimplantation genetic testing for aneuploidy using the progestin-primed ovarian stimulation protocol or the gonadotropin-releasing hormone antagonist protocol.

Objective: To investigate the chromosome abnormality rates and clinical pregnancy outcomes after preimplantation genetic testing for aneuploidy (PGT-A) using either the progestin-primed ovarian stimulation (PPOS) protocol or the gonadotropin-releasing hormone (GnRH) antagonist protocol.

Methods: The study included 431 PGT-A cycles in which controlled ovarian stimulation was performed using the PPOS protocol (n = 320 cycles) or GnRH antagonist protocol (n = 111 cycles) between January 2018 and December 2021. Frozen embryo transfer was subsequently performed in 307 cycles with transferable blastocysts.

Subretinal microglia support donor photoreceptor survival in rd1 mice.

Purpose: To investigate the potential relationship between subretinal microglia and transplanted donor photoreceptors.

Methods: Photoreceptor precursors were transplanted into wild-type mice and rd1 mice by trans-scleral injection. Immunohistochemistry was employed to detect microglia and macrophages.

The relationship between personality and short video addiction among college students is mediated by depression and anxiety.

Background: Short video addiction (SVA) among college students is influenced by personality traits, namely, neuroticism and agreeableness. However, the role of depression and anxiety as mediators remains unclear.

Objective: This study aims to explore the mediating role of comorbid depression and anxiety in the relationship between different dimensions of university students' personalities and SVA.

Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.

Objective: This study integrates network pharmacology and metabolomics techniques to explore the potential regulatory mechanisms of Res on gouty arthritis (GA).

Methods: Network pharmacology was used to predict the mechanism of Res in regulating GA, and methods such as HE staining, ELISA, immunohistochemistry, Real-time PCR, Western blot, and molecular docking were used to verify the role of NF-κB, MAPK, and JAK/STAT inflammatory signaling pathways in the MSU-induced GA rat model. In addition, non-targeted metabolomics techniques were combined to further investigate the mechanism of Res in treating GA.

Fully integrated multi-mode optoelectronic memristor array for diversified in-sensor computing.

In-sensor computing, which integrates sensing, memory and processing functions, has shown substantial potential in artificial vision systems. However, large-scale monolithic integration of in-sensor computing based on emerging devices with complementary metal-oxide-semiconductor (CMOS) circuits remains challenging, lacking functional demonstrations at the hardware level. Here we report a fully integrated 1-kb array with 128 × 8 one-transistor one-optoelectronic memristor (OEM) cells and silicon CMOS circuits, which features configurable multi-mode functionality encompassing three different modes of electronic memristor, dynamic OEM and non-volatile OEM (NV-OEM).

VDGE: a data repository of variation database for gene-edited animals across multiple species.

Gene-edited animals are crucial for addressing fundamental questions in biology and medicine and hold promise for practical applications. In light of the rapid advancement of gene editing technologies over the past decade, a dramatically increased number of gene-edited animals have been generated. Genome editing at off-target sites can, however, introduce genomic variations, potentially leading to unintended functional consequences in these animals.

Carnitine is a friend in HFpEF and foe in HFrEF.

Heart failure (HF) is a global concern, particularly HF with preserved ejection fraction (HFpEF), lacking effective treatments. Understanding the differences of metabolic profiles between HFpEF and HFrEF (heart failure with reduced ejection fraction) patients is crucial for therapeutic advancements. In this study, pseudotargeted metabolomics was employed to analyze for disparities of plasma metabolic profiles between HFpEF and HFrEF in two cohorts: discovery ( = 514) and validation ( = 3368).

MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.

Chronic obstructive pulmonary disease (COPD) is an irreversible and progressive chronic inflammatory lung disease which affects millions of people worldwide. Activated fibroblasts are observed to accumulate in lung of COPD patients and promote COPD progression through aberrant extracellular matrix (ECM) deposition. In this study, we identified that miR-1307-5p expression was significantly increased in lung fibroblasts derived from COPD patients.